Protein Alignment CG14780 and KLK1

DIOPT Version :10

• Sequence 1: NP_569920.2
• Gene: CG14780 / 31102
• FlyBaseID: FBgn0025383
• Length: 302
• Species: Drosophila melanogaster
• Sequence 2: NP_002248.1
• Gene: KLK1 / 3816
• HGNCID: 6357
• Length: 262
• Species: Homo sapiens
• Alignment Length: 277
• Identity: 85/277 - (30%)
• Similarity: 121/277 - (43%)
• Gaps: 43/277 - (15%)

  Fly    15 WFLLACAAADLQENQ-----QSRIINGSVAKADETRHLVSIRLLRHDNNFGSGHICGGALIAPRK 74
            |||:.|.|..|....     ||||:.|...:........:   |.|.:.|.    |||.|:..:.
Human     2 WFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAA---LYHFSTFQ----CGGILVHRQW 59

  Fly    75 VLTAAHCLYNNQRKRFRRASEFVVVLGTLNRFEHRNGTIVSQVS----------SMAYMHTFSPD 129
            |||||||:.:|          :.:.||..|.|:..|......||          |:...||...|
Human    60 VLTAAHCISDN----------YQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQAD 114

  Fly   130 SMRDDVG--ILFLRTGLPMSPGGGVHLTVAPIQLAGQITPPGKLCQVAGWGRTEQSSLS--NILL 190
               :|..  ::.||.   ..|...:...|..::|..:....|..|..:|||..|..:.|  :.|.
Human   115 ---EDYSHDLMLLRL---TEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQ 173

  Fly   191 TANVSTIRHQTCRMIYRSGLLPGMMCAGRLQGGTDSCQGDSGGPLVHEGRLVGVVSWGY-GCAEP 254
            ..::..:.:..|:..:...:...|:|.|.|:||.|:|.|||||||:.:|.|.||.|||| .|..|
Human   174 CVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTP 238

  Fly   255 GLPGVYVDVEYYRQWIE 271
            ..|.|.|.|..|.:|||
Human   239 NKPSVAVRVLSYVKWIE 255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14780	NP_569920.2	Tryp_SPc	33..271	CDD:238113	74/252 (29%)
KLK1	NP_002248.1	Tryp_SPc	25..257	CDD:238113	76/254 (30%)