DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14780 and PRSS53

DIOPT Version :9

Sequence 1:	NP_569920.2	Gene:	CG14780 / 31102	FlyBaseID:	FBgn0025383	Length:	302	Species:	Drosophila melanogaster
Sequence 2:	XP_011544118.1	Gene:	PRSS53 / 339105	HGNCID:	34407	Length:	623	Species:	Homo sapiens

Alignment Length:	288	Identity:	70/288 - (24%)
Similarity:	102/288 - (35%)	Gaps:	106/288 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 HICGGALIAPRKVLTAAHCLYNNQRKRFRRASEFVVVLGTLNRFEHRNGTIVSQVSSMAYMHTFS 127
            |||.|:|:|...|||||||.   ::......:.:.||||:|.|                  ...|
Human    60 HICSGSLVADTWVLTAAHCF---EKAAATELNSWSVVLGSLQR------------------EGLS 103

  Fly   128 PDSMRDDVGILFLRTGLP-----MSPGGGVHLTVAPIQLAGQIT-------------PPGKLCQV 174
            |.:  ::||:..|:  ||     .|.|..:.|    :|||...|             |.|..|..
Human   104 PGA--EEVGVAALQ--LPRAYNHYSQGSDLAL----LQLAHPTTHTPLCLPQPAHRFPFGASCWA 160

  Fly   175 AGWGRT-------------EQSSLSNILLTA---------------------------------N 193
            .||.:.             |...|.::.::|                                 .
Human   161 TGWDQDTSDGKCWPRLKLGEALCLPSVTVSAPNCPGFQSPLLPRSQTLAPAPSLSPAPGTLRNLR 225

  Fly   194 VSTIRHQTCRMIYR--------SGLLPGMMCAGRLQGGTDSCQGDSGGP---LVHEGRLV--GVV 245
            :..|...||..||.        :...|||:|.|...|....||||||||   |..:|..|  |::
Human   226 LRLISRPTCNCIYNQLHQRHLSNPARPGMLCGGPQPGVQGPCQGDSGGPVLCLEPDGHWVQAGII 290

  Fly   246 SWGYGCAEPGLPGVYVDVEYYRQWIEGR 273
            |:...||:...|.:..:...:..|::.|
Human   291 SFASSCAQEDAPVLLTNTAAHSSWLQAR 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14780	NP_569920.2	Tryp_SPc	32..270	CDD:214473	68/283 (24%)
CG14780	NP_569920.2	Tryp_SPc	33..271	CDD:238113	69/284 (24%)
PRSS53	XP_011544118.1	Tryp_SPc	42..316	CDD:238113	69/284 (24%)
		Tryp_SPc	43..314	CDD:214473	68/282 (24%)
		Tryp_SPc	359..>512	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24276
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100