DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14780 and PRSS36

DIOPT Version :9

Sequence 1:	NP_569920.2	Gene:	CG14780 / 31102	FlyBaseID:	FBgn0025383	Length:	302	Species:	Drosophila melanogaster
Sequence 2:	NP_775773.2	Gene:	PRSS36 / 146547	HGNCID:	26906	Length:	855	Species:	Homo sapiens

Alignment Length:	257	Identity:	87/257 - (33%)
Similarity:	124/257 - (48%)	Gaps:	32/257 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SRIINGSVAKADETRHLVSIRLLRHDNNFGSGHICGGALIAPRKVLTAAHCLYNNQRKRFRRASE 95
            :||:.||.|:.......||   |.|    |.||||||:||||..||:||||...|  .....|:|
Human    45 ARIVGGSNAQPGTWPWQVS---LHH----GGGHICGGSLIAPSWVLSAAHCFMTN--GTLEPAAE 100

  Fly    96 FVVVLGTLNRFEHRNGTIVSQVSSMAYMHTFSPDSMRDDVGILFLRTGLPMSPGGGVHLTVAPIQ 160
            :.|:||..::....:|.....|:::.....:|...:..|:.:|.|.:...:.|      .|.|:.
Human   101 WSVLLGVHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGP------AVWPVC 159

  Fly   161 L--AGQITPPGKLCQVAGWGRTEQSS---LSNILLTANVSTIRHQTCRMIYRS--------GLLP 212
            |  |......|..|...|||..:::.   |..:|....:..:...||:.:|..        .:||
Human   160 LPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQPGPFNLTLQILP 224

  Fly   213 GMMCAGRLQGGTDSCQGDSGGPLVHE--GR--LVGVVSWGYGCAEPGLPGVYVDVEYYRQWI 270
            ||:|||..:|..|:||||||||||.|  ||  ..|:.|:|:||.....|||:..|..|..||
Human   225 GMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGRRNRPGVFTAVATYEAWI 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14780	NP_569920.2	Tryp_SPc	32..270	CDD:214473	85/254 (33%)
CG14780	NP_569920.2	Tryp_SPc	33..271	CDD:238113	86/255 (34%)
PRSS36	NP_775773.2	Tryp_SPc	46..286	CDD:214473	85/254 (33%)
		Tryp_SPc	47..289	CDD:238113	86/255 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..316
		Tryp_SPc	330..538	CDD:304450
		Tryp_SPc	601..783	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24276
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010