DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment O-fut2 and pofut2

DIOPT Version :9

Sequence 1:	NP_569916.1	Gene:	O-fut2 / 31098	FlyBaseID:	FBgn0027791	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_001072179.1	Gene:	pofut2 / 779585	XenbaseID:	XB-GENE-1018927	Length:	435	Species:	Xenopus tropicalis

Alignment Length:	504	Identity:	177/504 - (35%)
Similarity:	247/504 - (49%)	Gaps:	104/504 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SWPRLGFPALLLLLHLLTGSDAAVRNGTAKREIGDSRGSSGTCVKGFLQEILPLPATCPPE---- 64
            ||.    |.|||||                          |.|:.       .||..|..|
Frog     5 SWR----PRLLLLL--------------------------GVCLS-------LLPRACGDEGQFS 32

  Fly    65 ------VLGMRGAV----YILYDVNISEGFNLRRDVYIRMAVFVRRLQRRRRFRHVRLVLPPWPR 119
                  .|.:..|.    |:|||||..||||||||||||:|..::.|.:...:   .||||||.|
Frog    33 PGHSASSLQVGTAAFERRYLLYDVNPPEGFNLRRDVYIRVASLLKTLLKSSNW---VLVLPPWGR 94

  Fly   120 LYHWHSQGLQQSGLPWSHFFDLASLRRYAPVLDYEEFLAEQRLFGNPGAPLVHVGHAFRLQHYEV 184
            ||||.|..:.|..:||:.||||.||.:..||::||:||||.      |.|.:.  ..:.||.|..
Frog    95 LYHWQSPDIHQVRIPWAEFFDLDSLYQNIPVIEYEDFLAES------GGPFIE--QVYVLQGYAE 151

  Fly   185 MLEQGIFRDKFERVTDKPCSEGSLSGGPLLQQAELRVGRFH---------------CVRFQGSAG 234
            ..::|.:.   |:|..:||.:       .|..:|.:.|.:.               |:..||||.
Frog   152 GWKEGTWE---EKVDQRPCID-------QLMYSEDKNGYYRGWFWGYEETRGINVTCLSVQGSAS 206

  Fly   235 LLEKLLREAIDEDTAGPEDVDDMRTYALLSAETVLHDHWGDEHFWQARRSMRFARRLEQVAADFR 299
            ::..:|   :...||        |:..|..||.:||||:|.:.:|..||||.||:.|..|..:||
Frog   207 IMAPVL---LKNTTA--------RSVMLDRAENLLHDHYGGKDYWDTRRSMVFAKHLRVVGDEFR 260

  Fly   300 RQALDTTDASAGVQRPAMWELERPK-RNAKGGDYLCAHLRRGDFVRSRDATTPTLKAAAQQVKQL 363
            ...|.:||.:........|...:.| .:|.||.||..||||.||:.......|:|:.||.::..|
Frog   261 ANFLHSTDEADRTIFHEDWTKVKAKPDSALGGPYLAVHLRRKDFIWGHREDVPSLRRAADEIHSL 325

  Fly   364 LRGFNMTTVFLATDATPYELMELKELFYRFRLVHFAPESNVQRREL-KDGGVAVVDQLVCAYARY 427
            ::...:..||:||||...:|..|::|..  .:|.|  |:..:..|| ||||||::||.:||:|||
Frog   326 MKKLKLKKVFVATDADREDLEALRKLIP--EMVRF--EATWEELELYKDGGVAIIDQWICAHARY 386

  Fly   428 FVGTYESTFTYRIYEEREILGFTQASTFNTFCKALGGSCSRNAVWPIVW 476
            |:||..|||::||:||||||.|...:|:|.||.....:|.:...|.||:
Frog   387 FIGTSVSTFSFRIHEEREILSFNPKTTYNRFCGDKEKNCEQPTHWKIVY 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
O-fut2	NP_569916.1	O-FucT-2	73..460	CDD:211384	156/403 (39%)
O-fut2	NP_569916.1	O-FucT	78..454	CDD:287252	149/392 (38%)
pofut2	NP_001072179.1	O-FucT-2	51..420	CDD:211384	157/404 (39%)
pofut2	NP_001072179.1	O-FucT	56..414	CDD:287252	149/393 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	238	1.000	Domainoid score	I2264
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12724
Inparanoid	1	1.050	259	1.000	Inparanoid score	I3051
OMA	1	1.010	-	-		QHG58563
OrthoDB	1	1.010	-	-		D286553at33208
OrthoFinder	1	1.000	-	-		FOG0006576
OrthoInspector	1	1.000	-	-		oto103084
Panther	1	1.100	-	-	LDO	PTHR13398
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4817
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080