DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment O-fut2 and pofut2

DIOPT Version :9

Sequence 1:	NP_569916.1	Gene:	O-fut2 / 31098	FlyBaseID:	FBgn0027791	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_001071098.2	Gene:	pofut2 / 777668	ZFINID:	ZDB-GENE-030131-3595	Length:	444	Species:	Danio rerio

Alignment Length:	424	Identity:	168/424 - (39%)
Similarity:	230/424 - (54%)	Gaps:	39/424 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 PEVLGMRGAVYILYDVNISEGFNLRRDVYIRMAVFVRRLQRRRRFRHVRLVLPPWPRLYHWHSQG 127
            |.....|...|:|||||..||||||||||||||..::.|::...:   .||||||.|||||.|..
Zfish    50 PVAAASRDVRYLLYDVNPPEGFNLRRDVYIRMATLLKTLRKEGDW---VLVLPPWGRLYHWQSPE 111

  Fly   128 LQQSGLPWSHFFDLASLRRYAPVLDYEEFLAEQRLFGNPGAPLVHVGHAFRLQHYEVMLEQGIFR 192
            :.|..:||..||.:.||:...||::||||:||.      |.|.  :.....||.|......|.:.
Zfish   112 IHQLRIPWGEFFSITSLQANIPVIEYEEFIAES------GGPF--IDQILVLQSYAEGWTDGKWE 168

  Fly   193 DKFERVTDKPCSEGSLSG--------GPLLQQAELRVGRFHCVRFQGSAGLLEKLLREAIDEDTA 249
               |:|.|:||.|..:..        |......|.|.....|:..||.|.:|..:|:..|   ||
Zfish   169 ---EKVDDRPCIEKLMYSKDKQGYYRGWFWGFEETRALNVTCLSAQGHASILAPVLQNNI---TA 227

  Fly   250 GPEDVDDMRTYALLSAETVLHDHWGDEHFWQARRSMRFARRLEQVAADFRRQALDTTDASAGVQR 314
            ....||        .||||||||:..:.:|..||||.||:.|..:...||...|::||.......
Zfish   228 TSVMVD--------RAETVLHDHYAGKDYWDTRRSMVFAKHLRIIGDKFRANHLNSTDKQDQTPY 284

  Fly   315 PAMW-ELERPKRNAKGGDYLCAHLRRGDFVRSRDATTPTLKAAAQQVKQLLRGFNMTTVFLATDA 378
            ...| :::.|..:||||.||..||||.||:.......|:||.|.::::.|::...:..||:||||
Zfish   285 NEDWTQMKNPLGSAKGGPYLGVHLRRKDFIWGHREDVPSLKGAVKKIRSLMKKHKLLQVFVATDA 349

  Fly   379 TPYELMELKELFYRFRLVHFAPESNVQRRE-LKDGGVAVVDQLVCAYARYFVGTYESTFTYRIYE 442
            ...||.:||.|..  .:|.|.|  :::..| |||||||::||.:||:||:|:||..|||::||:|
Zfish   350 DEEELAKLKRLLP--EMVRFEP--SLEDLELLKDGGVAIIDQWICAHARFFIGTSVSTFSFRIHE 410

  Fly   443 EREILGFTQASTFNTFCKALGGSCSRNAVWPIVW 476
            |||||||...:|:|.||..:...|.:...|.||:
Zfish   411 EREILGFDPKTTYNRFCGDVEQECEQPTHWKIVY 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
O-fut2	NP_569916.1	O-FucT-2	73..460	CDD:211384	161/396 (41%)
O-fut2	NP_569916.1	O-FucT	78..454	CDD:287252	154/385 (40%)
pofut2	NP_001071098.2	O-FucT-2	60..429	CDD:211384	162/397 (41%)
pofut2	NP_001071098.2	O-FucT	65..423	CDD:287252	154/386 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594435
Domainoid	1	1.000	246	1.000	Domainoid score	I2127
eggNOG	1	0.900	-	-		E1_2CB2G
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12724
Inparanoid	1	1.050	271	1.000	Inparanoid score	I2968
OMA	1	1.010	-	-		QHG58563
OrthoDB	1	1.010	-	-		D286553at33208
OrthoFinder	1	1.000	-	-		FOG0006576
OrthoInspector	1	1.000	-	-		oto40707
orthoMCL	1	0.900	-	-		OOG6_107032
Panther	1	1.100	-	-	LDO	PTHR13398
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2701
SonicParanoid	1	1.000	-	-		X4817
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800