DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment O-fut2 and POFUT2

DIOPT Version :9

Sequence 1:	NP_569916.1	Gene:	O-fut2 / 31098	FlyBaseID:	FBgn0027791	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	XP_024307826.1	Gene:	POFUT2 / 23275	HGNCID:	14683	Length:	510	Species:	Homo sapiens

Alignment Length:	495	Identity:	168/495 - (33%)
Similarity:	238/495 - (48%)	Gaps:	120/495 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 YILYDVNISEGFNLRRDVYIRMAVFVRRLQRRRRFRHVRLVLPPWPRLYHWHSQGLQQSGLPWSH 137
            |:|||||..||||||||||||:|..::.|.:...:   .||||||.|||||.|..:.|..:|||.
Human    45 YLLYDVNPPEGFNLRRDVYIRIASLLKTLLKTEEW---VLVLPPWGRLYHWQSPDIHQVRIPWSE 106

  Fly   138 FFDLASLRRYAPVLDYEEFLAEQRLFGNPGAPLVHVGHAFRLQHYEVMLEQGIFRDKFERVTDKP 202
            ||||.||.:..||::||:|:||.   |.|....|:|     ||.|....::|.:.   |:|.::|
Human   107 FFDLPSLNKNIPVIEYEQFIAES---GGPFIDQVYV-----LQSYAEGWKEGTWE---EKVDERP 160

  Fly   203 CSEGSL----------------------------------------------SGG---------- 211
            |.:..|                                              .||
Human   161 CIDQLLYSQDKHEYYRRFPFVLRPGEWAVMNIWLRPRASFPVSFHAFGCCHRDGGLVSPKCRLPL 225

  Fly   212 --------------------PLLQQAELRVGR-------------FHCVRFQGSAGLLEKLLREA 243
                                |:..|..|:.||             ..|:..||||.::..||.
Human   226 KALTLPGLLWKSCQLTASMCPVPGQLALKHGRGWFWGYEETRGLNVSCLSVQGSASIVAPLLL-- 288

  Fly   244 IDEDTAGPEDVDDMRTYALLSAETVLHDHWGDEHFWQARRSMRFARRLEQVAADFRRQALDTTDA 308
              .:|:.       |:..|..||.:||||:|.:.:|..||||.|||.|.:|..:||.:.|::||.
Human   289 --RNTSA-------RSVMLDRAENLLHDHYGGKEYWDTRRSMVFARHLREVGDEFRSRHLNSTDD 344

  Fly   309 SAGVQRPAMWELERPK-RNAKGGDYLCAHLRRGDFVRSRDATTPTLKAAAQQVKQLLRGFNMTTV 372
            :..:.....|...:.| .:|.||.||..||||.||:.......|:|:.|.::::.|::...:..|
Human   345 ADRIPFQEDWMKMKVKLGSALGGPYLGVHLRRKDFIWGHRQDVPSLEGAVRKIRSLMKTHRLDKV 409

  Fly   373 FLATDATPYELMELKELFYRFRLVHFAPESNVQRREL-KDGGVAVVDQLVCAYARYFVGTYESTF 436
            |:||||...|..|||:|..  .:|.|.|  ..:..|| ||||||::||.:||:||:|:||..|||
Human   410 FVATDAVRKEYEELKKLLP--EMVRFEP--TWEELELYKDGGVAIIDQWICAHARFFIGTSVSTF 470

  Fly   437 TYRIYEEREILGFTQASTFNTFCKALGGSCSRNAVWPIVW 476
            ::||:|||||||....:|:|.||.....:|.:...|.|.:
Human   471 SFRIHEEREILGLDPKTTYNRFCGDQEKACEQPTHWKITY 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
O-fut2	NP_569916.1	O-FucT-2	73..460	CDD:211384	164/477 (34%)
O-fut2	NP_569916.1	O-FucT	78..454	CDD:287252	157/466 (34%)
POFUT2	XP_024307826.1	O-FucT-2	45..495	CDD:211384	165/478 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158496
Domainoid	1	1.000	247	1.000	Domainoid score	I2163
eggNOG	1	0.900	-	-		E1_2CB2G
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12724
Inparanoid	1	1.050	265	1.000	Inparanoid score	I3068
Isobase	1	0.950	-	0	Normalized mean entropy	S3965
OMA	1	1.010	-	-		QHG58563
OrthoDB	1	1.010	-	-		D286553at33208
OrthoFinder	1	1.000	-	-		FOG0006576
OrthoInspector	1	1.000	-	-		oto89247
orthoMCL	1	0.900	-	-		OOG6_107032
Panther	1	1.100	-	-	LDO	PTHR13398
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2701
SonicParanoid	1	1.000	-	-		X4817
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750