DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ns3 and gnl1

DIOPT Version :9

Sequence 1:	NP_001284779.1	Gene:	Ns3 / 31097	FlyBaseID:	FBgn0266284	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_001070721.1	Gene:	gnl1 / 568505	ZFINID:	ZDB-GENE-060323-1	Length:	602	Species:	Danio rerio

Alignment Length:	667	Identity:	177/667 - (26%)
Similarity:	287/667 - (43%)	Gaps:	153/667 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KKNKGGAPNLGRQLIKDRFGHTQRRKVDNDTMLHTTEL---------QDG-YDWGRLNLSSVTE- 56
            |:.:.|:.:..|....:|.....|:...:|:  .||::         :|| ||..|..|....|
Zfish    23 KRGETGSGHSSRNASVERGPGRDRQSDTSDS--ETTDIRRINHQPGTRDGRYDPNRFRLHFEKES 85

  Fly    57 ESSFQAFLRTAELAGTEFQAEKLNITFVNPKQRVGLLSKTQEQRMHQKHDEHRDQLKIPRRPKWT 121
            :...:...:||.        ||:    :.|     ::.|..|..::|.:.|.:. |..||||.|.
Zfish    86 KEDVEKRKKTAR--------EKI----LKP-----VVEKELEMDINQIYPEDKG-LNFPRRPSWN 132

  Fly   122 KETSAEELVRAENEAFLDWRRDLALLQEDEEILMTPYEKNLEFWRQLWRVVERSDVVVQIVDARN 186
            .....|||:|.|.::||::..  ||..::....::.:|.|||.|||||||:|.|||::.|||.|:
Zfish   133 YSMQREELLRKEEKSFLEYLE--ALHSKNPPGTLSHFEHNLETWRQLWRVIEMSDVILLIVDIRH 195

  Fly   187 PLLFRSADLERYVKEVEPSKMNMILVNKSDLLTEEQRRHWAEYFDSEGIRTAF------------ 239
            |:|.....|..|:.| |..|..::::||:||........|.:|...:     |
Zfish   196 PVLQFPPALYHYITE-ELKKHIILVLNKADLCPAPLVLAWKDYLTKQ-----FPHLHCVCFTSHP 254

  Fly   240 ---YSATLVEEELKREA------------EEC-------LDSFPEVQQLRRAVEEIKQSLDSVED 282
               ||..|.::.::::|            ..|       :|.....::::|....:....|..:|
Zfish   255 GQPYSTLLQKKRMRKKAGWNHAGGPIHIMRVCQEITAGRVDLSSWEKKIQRDAVAVGNEGDRADD 319

  Fly   283 ALNVIEQKYKTIPETQNDELPRLPGDKNSPRLLSRLELIEFLRNIYTGPRHTEQHVTVGMVGYPN 347
            ....:      :.|..:|    :..:.|||                |...:.:..:|:|.:|:||
Zfish   320 GSESV------LMEHHSD----IAMEMNSP----------------TQELYKDGVLTLGCIGFPN 358

  Fly   348 VGKSSTINSLMTVKKVSVSATPGKTKRFQTLFLDKDILLCDCPGLVMPSFVLTKADMLLNGILPI 412
            |||||.:|||:..|.||||.|||.||.|||.:|...:.||||||||.||.| .|...:|.||.|:
Zfish   359 VGKSSVLNSLVGRKVVSVSRTPGHTKYFQTYYLTPTVKLCDCPGLVFPSRV-DKQLQVLAGIYPV 422

  Fly   413 DQMRDHVPAVNLLCERIPRHVLEDKYGIVIAKPLEGEDMERPPHSE--------ELLLAYGYNRG 469
            .|:::...:|..||||       ..| :.|.|....:.....||..        ::..|:...||
Zfish   423 SQLQEPYSSVGHLCER-------TNY-LSILKLTHPDHSPETPHDPSTQDWTAWDVCEAWAERRG 479

  Fly   470 FMTSN-GQPDQARSARYVLKDYVNGRLLYAMSPPSVPQTE--YHTFPERQRRVIEESQLPGQQQ- 530
            :.|:. .:.|..|:|..:|:..::|||...:.||...|::  :.:.|:    :.|...|.|:::
Zfish   480 YKTAKAARNDVYRAANSLLRLAIDGRLCLCLRPPGYSQSKDTWESHPD----LAEIIALQGRKED 540

  Fly   531 ------RAMRINKSTSKELDNQFFSDKPTHAHVKGRTNFPNVRLANDGSLVAGNDPAAKPWRHVK 589
                  |.....:|:| ||:..                  |.|.|:|.....|:|..    ..||
Zfish   541 GDECGDREEEDGESSS-ELEED------------------NDRDADDDEDADGDDED----ETVK 582

  Fly   590 KERREKLRKKFSHLDEH 606
            .:|:......||.|.|:
Zfish   583 ADRKGLTLNMFSVLGEN 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ns3	NP_001284779.1	RbgA	161..524	CDD:224083	117/407 (29%)
		HSR1_MMR1	164..395	CDD:206750	79/264 (30%)
		p10	<270..312	CDD:177631	5/41 (12%)
		P-loop_NTPase	313..>357	CDD:304359	12/43 (28%)
gnl1	NP_001070721.1	HSR1_MMR1	173..406	CDD:206750	79/264 (30%)
gnl1	NP_001070721.1	rbgA	175..508	CDD:236570	108/373 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55394
OrthoDB	1	1.010	-	-		D206558at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.830