Protein Alignment Ns3 and LSG1

DIOPT Version :10

• Sequence 1: NP_569915.1
• Gene: Ns3 / 31097
• FlyBaseID: FBgn0266284
• Length: 606
• Species: Drosophila melanogaster
• Sequence 2: NP_060855.2
• Gene: LSG1 / 55341
• HGNCID: 25652
• Length: 658
• Species: Homo sapiens
• Alignment Length: 665
• Identity: 306/665 - (46%)
• Similarity: 413/665 - (62%)
• Gaps: 69/665 - (10%)

  Fly     1 MGKKNKGGAPNLGRQLIKDRFGHTQRRKV--DNDTMLHTTELQDGYDWGRLNLSSVTEESSFQAF 63
            ||::......:|||.|::.:   |||.:.  ..|:.|||:||.||||||||||.||||:||...|
Human     1 MGRRRAPAGGSLGRALMRHQ---TQRSRSHRHTDSWLHTSELNDGYDWGRLNLQSVTEQSSLDDF 62

  Fly    64 LRTAELAGTEFQAEKLNITFVNPKQRVGLLSKTQEQRMHQKHDEHRDQLKIPRRPKWTKETSAEE 128
            |.|||||||||.||||||.||..:.|.||||..:.||:.:.|:|::..|.|||||.|.:.|:.||
Human    63 LATAELAGTEFVAEKLNIKFVPAEARTGLLSFEESQRIKKLHEENKQFLCIPRRPNWNQNTTPEE 127

  Fly   129 LVRAENEAFLDWRRDLALLQEDEEILMTPYEKNLEFWRQLWRVVERSDVVVQIVDARNPLLFRSA 193
            |.:||.:.||:|||.|..|:|::::::||:|:||:||||||||:||||:||||||||||||||..
Human   128 LKQAEKDNFLEWRRQLVRLEEEQKLILTPFERNLDFWRQLWRVIERSDIVVQIVDARNPLLFRCE 192

  Fly   194 DLERYVKEVEPSKMNMILVNKSDLLTEEQRRHWAEYFDSEGIRTAFYSATL--------VEEELK 250
            |||.||||::.:|.|:||:||:||||.|||..||.||:.|.::..|:||..        .|||..
Human   193 DLECYVKEMDANKENVILINKADLLTAEQRSAWAMYFEKEDVKVIFWSALAGAIPLNGDSEEEAN 257

  Fly   251 REAEEC------LDSFPEVQQLRRAVEEIKQSLDSVEDALNVI----EQKYKTIPETQNDE---- 301
            |:..:.      ..||.:. ::..:..|...:.||...:.|..    :.:|:..||.:.|:
Human   258 RDDRQSNTTKFGHSSFDQA-EISHSESEHLPARDSPSLSENPTTDEDDSEYEDCPEEEEDDWQTC 321

  Fly   302 -----------------------------LPRLPGDKNSPRLLSRLELIEFLRNIYTGPRHTEQH 337
                                         .|:.....|...|:|:.||:|..:.::||.:..:..
Human   322 SEEDGPKEEDCSQDWKESSTADSEARSRKTPQKRQIHNFSHLVSKQELLELFKELHTGRKVKDGQ 386

  Fly   338 VTVGMVGYPNVGKSSTINSLMTVKKVSVSATPGKTKRFQTLFLDKDILLCDCPGLVMPSFVLTKA 402
            :|||:|||||||||||||::|..||||||||||.||.||||:::..:.|||||||||||||.|||
Human   387 LTVGLVGYPNVGKSSTINTIMGNKKVSVSATPGHTKHFQTLYVEPGLCLCDCPGLVMPSFVSTKA 451

  Fly   403 DMLLNGILPIDQMRDHVPAVNLLCERIPRHVLEDKYGIVIAKPLEGEDMERPPHSEELLLAYGYN 467
            :|..:|||||||||||||.|:|:|:.|||||||..|||.|..|.|.||..|||.|||||.||||.
Human   452 EMTCSGILPIDQMRDHVPPVSLVCQNIPRHVLEATYGINIITPREDEDPHRPPTSEELLTAYGYM 516

  Fly   468 RGFMTSNGQPDQARSARYVLKDYVNGRLLYAMSPPSVPQTEYHTFPERQRRVIEESQLPGQQQRA 532
            |||||::|||||.|||||:|||||:|:|||...||.   .:..||..:.:|::|......:.:..
Human   517 RGFMTAHGQPDQPRSARYILKDYVSGKLLYCHPPPG---RDPVTFQHQHQRLLENKMNSDEIKMQ 578

  Fly   533 MRINKSTSKELDN----QFFSDKPTHAHVKGRTNFPNVRLAN---DGSLVAGNDPAAKPW-RHVK 589
            :..||. :|:::|    .||..:...|..||.......:..:   ..|..:..:.|.||| :|..
Human   579 LGRNKK-AKQIENIVDKTFFHQENVRALTKGVQAVMGYKPGSGVVTASTASSENGAGKPWKKHGN 642

  Fly   590 KERREKLRKKFSHLD 604
            :.::||.|:.:.|||
Human   643 RNKKEKSRRLYKHLD 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ns3	NP_569915.1	HSR1_MMR1	164..395	CDD:206750	118/281 (42%)
		RbgA	176..495	CDD:440775	180/369 (49%)
LSG1	NP_060855.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		9/32 (28%)
		HSR1_MMR1	163..444	CDD:206750	118/281 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	250..355		15/105 (14%)
		RbgA	<367..544	CDD:440775	119/176 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..658		12/35 (34%)