DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ns3 and GNL3L

DIOPT Version :9

Sequence 1:	NP_001284779.1	Gene:	Ns3 / 31097	FlyBaseID:	FBgn0266284	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_001171748.1	Gene:	GNL3L / 54552	HGNCID:	25553	Length:	582	Species:	Homo sapiens

Alignment Length:	496	Identity:	125/496 - (25%)
Similarity:	209/496 - (42%)	Gaps:	100/496 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 FVNPK---QRVGLLSKTQEQRMHQKHDEHRDQLKIPRRPKWTKETSAEELVRAENEAFLDWRRDL 144
            ||:|.   .|...|.|...:.|.:|....|:|.:..||   |.|:..::::|.:.|
Human    46 FVHPNDHANREAELKKKWVEEMREKQQAAREQERQKRR---TIESYCQDVLRRQEE--------- 98

  Fly   145 ALLQEDEEILMTPYEKNL-----------EFWRQLWRVVERSDVVVQIVDARNPLLFRSADLERY 198
              .:..||:|.   |.|:           .::::..:|||.|||:::::|||:||..|...:|..
Human    99 --FEHKEEVLQ---ELNMFPQLDDEATRKAYYKEFRKVVEYSDVILEVLDARDPLGCRCFQMEEA 158

  Fly   199 VKEVEPSKMNMILVNKSDLLTEEQRRHWAEYFDSEGIRTAFYSATLVEEELKREAEECLDSFPEV 263
            |...:.:|..::::||.||:.:|....|.:|..:|....||.::|.                .:|
Human   159 VLRAQGNKKLVLVLNKIDLVPKEVVEKWLDYLRNELPTVAFKASTQ----------------HQV 207

  Fly   264 QQLRRAVEEIKQSLDSVEDALNVIEQKYKTIPETQNDELPRLPGDKNSPRLLSRLELIEFLRNIY 328
            :.|.|....:.|:.:|:        .|.|.....:|                    |:..|.| |
Human   208 KNLNRCSVPVDQASESL--------LKSKACFGAEN--------------------LMRVLGN-Y 243

  Fly   329 TGPRHTEQHVTVGMVGYPNVGKSSTINSLMTVKKVSVSATPGKTKRFQTLFLDKDILLCDCPGLV 393
            ........|:.||:||.|||||||.||||...:..||.|.||.||..|.::|||.|.|.|.||:|
Human   244 CRLGEVRTHIRVGVVGLPNVGKSSLINSLKRSRACSVGAVPGITKFMQEVYLDKFIRLLDAPGIV 308

  Fly   394 M-PSFVLTKADMLLNGILPIDQMRDHVPAVNLLCERIPRHVLEDKYGIVIAKPLEGEDMERPPHS 457
            . |:   ::...:|...:.:.::.|.|..|..:.:|.....:.:.||:      .|...     :
Human   309 PGPN---SEVGTILRNCVHVQKLADPVTPVETILQRCNLEEISNYYGV------SGFQT-----T 359

  Fly   458 EELLLAYGYNRGFMTSNGQPDQARSARYVLKDYVNGRLLYAMSPPSVPQTEYHTFPERQRRVIEE 522
            |..|.|..:..|.....|...|.::|:.||.|:|:|::.:.:.||:......|...|..:.:.|.
Human   360 EHFLTAVAHRLGKKKKGGLYSQEQAAKAVLADWVSGKISFYIPPPATHTLPTHLSAEIVKEMTEV 424

  Fly   523 SQLPGQQQRAMRINKSTSK-----ELDNQFFSDKPTHAHVK 558
            ..:...:|    .|:.|.:     |.|.......|....:|
Human   425 FDIEDTEQ----ANEDTMECLATGESDELLGDTDPLEMEIK 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ns3	NP_001284779.1	RbgA	161..524	CDD:224083	98/374 (26%)
		HSR1_MMR1	164..395	CDD:206750	71/231 (31%)
		p10	<270..312	CDD:177631	5/41 (12%)
		P-loop_NTPase	313..>357	CDD:304359	18/43 (42%)
GNL3L	NP_001171748.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		4/11 (36%)
		Required for nucleolar localization	9..35
		Nucleostemin_like	136..307	CDD:206753	65/215 (30%)
		MnmE_helical	251..>405	CDD:331155	55/167 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810