Protein Alignment Ns3 and GNL2

DIOPT Version :10

• Sequence 1: NP_569915.1
• Gene: Ns3 / 31097
• FlyBaseID: FBgn0266284
• Length: 606
• Species: Drosophila melanogaster
• Sequence 2: NP_001310552.1
• Gene: GNL2 / 29889
• HGNCID: 29925
• Length: 799
• Species: Homo sapiens
• Alignment Length: 624
• Identity: 149/624 - (23%)
• Similarity: 258/624 - (41%)
• Gaps: 140/624 - (22%)

  Fly    11 NLGRQLIKDRFGHTQRRKVDNDTMLHTT-------ELQDGYDWGRLNLSSVTEESSFQAFLRTAE 68
            |:.||  |:|  ...|.|:.......:|       .::....|  ...:.|.::||.|.|
Human    42 NMYRQ--KER--RNSRGKIIKPLQYQSTVASGTVARVEPNIKW--FGNTRVIKQSSLQKF----- 95

  Fly    69 LAGTEFQAEKLNITFVNPKQRVGLLSKTQEQRMHQKHDEHRDQLKI---------------PRRP 118
                   .|:::....:|.:.|...||.....:|.:...|..::.|               .:||
Human    96 -------QEEMDTVMKDPYKVVMKQSKLPMSLLHDRIRPHNLKVHILDTESFETTFGPKSQRKRP 153

  Fly   119 KWTKETSAEELVRAE--NEAFLDWRRDLALLQED--------EEILMTPYEKNLEFWRQLWRVVE 173
            ..........:..||  .|:: |..:|..|:.||        |||......|.:  |.:|::|::
Human   154 NLFASDMQSLIENAEMSTESY-DQGKDRDLVTEDTGVRNEAQEEIYKKGQSKRI--WGELYKVID 215

  Fly   174 RSDVVVQIVDARNPLLFRSADLERYVKEVEPSKMNMILVNKSDLLTEEQRRHWAEYFDSEGIRTA 238
            .||||||::|||:|:..||..:|.|:|:.:|.|..:.::||.||:.....:.|.... |:...|.
Human   216 SSDVVVQVLDARDPMGTRSPHIETYLKKEKPWKHLIFVLNKCDLVPTWATKRWVAVL-SQDYPTL 279

  Fly   239 FYSATLVEE-------ELKRE-------AEECLDSFP--------------EVQQLRRAVEEIKQ 275
            .:.|:|...       :|.|:       ....|..||              .|..|.||:.:.|.
Human   280 AFHASLTNPFGKGAFIQLLRQFGKPWHLTFHALLGFPGLLCILCPWSPCSFYVLWLERALPKFKL 344

  Fly   276 SLDSVEDALNVIEQKYKTIPETQNDELPRLPGDKNSPRLLSRLELIEFLRNIYTGPRHTEQHVTV 340
            .:.....|           ||....  .|||           .::::...:::|    .::.::|
Human   345 QIPGQTSA-----------PEGSRG--TRLP-----------YQILKASCSLHT----DKKQISV 381

  Fly   341 GMVGYPNVGKSSTINSLMTVKKVSVSATPGKTKRFQTLFLDKDILLCDCPGLVMPSFVLTKADML 405
            |.:|||||||||.||:|.:.|..:|:...|:||.:|.:.|.:.|.|.||||:|.|| ..::.|::
Human   382 GFIGYPNVGKSSVINTLRSKKVCNVAPIAGETKVWQYITLMRRIFLIDCPGVVYPS-EDSETDIV 445

  Fly   406 LNGILPIDQMR---DHVPAVNLLCERIPRHVLEDKYGIVIAKPLEGEDMERPPHSEELLLAYGYN 467
            |.|::.:::::   ||:.||   .||.....:...|.|        :..|   ::|:.|....:.
Human   446 LKGVVQVEKIKSPEDHIGAV---LERAKPEYISKTYKI--------DSWE---NAEDFLEKLAFR 496

  Fly   468 RGFMTSNGQPDQARSARYVLKDYVNGRLLYAMSPPSV-PQTEYHTFPERQRRVIEES--QLPGQQ 529
            .|.:...|:||.....:.||.|:..||:.:.:.||:. |.......|.....|:.|:  ..||::
Human   497 TGKLLKGGEPDLQTVGKMVLNDWQRGRIPFFVKPPNAEPLVAPQLLPSSSLEVVPEAAQNNPGEE 561

  Fly   530 --QRAMRINKSTSKELDNQFFSDKPTHAHVKGRTNFPNV 566
              :.|...::|..||       :...::|....|....:
Human   562 VTETAGEGSESIIKE-------ETEENSHCDANTEMQQI 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ns3	NP_569915.1	HSR1_MMR1	164..395	CDD:206750	74/258 (29%)
		RbgA	176..495	CDD:440775	94/349 (27%)
GNL2	NP_001310552.1	NGP1NT	43..174	CDD:462379	26/148 (18%)
		NGP_1	209..433	CDD:206751	71/252 (28%)
		RbgA	218..524	CDD:440775	94/349 (27%)