DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ns3 and Lsg1

DIOPT Version :9

Sequence 1:	NP_001284779.1	Gene:	Ns3 / 31097	FlyBaseID:	FBgn0266284	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_001013439.1	Gene:	Lsg1 / 288029	RGDID:	1309089	Length:	655	Species:	Rattus norvegicus

Alignment Length:	669	Identity:	314/669 - (46%)
Similarity:	412/669 - (61%)	Gaps:	80/669 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKKNKGGAPNLGRQLIKDRFGHTQRRKV--DNDTMLHTTELQDGYDWGRLNLSSVTEESSFQAF 63
            ||::...|..:|||.||:.:   |||.:.  ..|:.|||:||.||||||||||.||||:||.:.|
  Rat     1 MGRRRAPGGGSLGRVLIRHQ---TQRSRSHRHTDSWLHTSELNDGYDWGRLNLQSVTEQSSLEDF 62

  Fly    64 LRTAELAGTEFQAEKLNITFVNPKQRVGLLSKTQEQRMHQKHDEHRDQLKIPRRPKWTKETSAEE 128
            |.|||||||||.||||||.||.|:.|.||||..:.||:.:.|:|:|..|.|||||.|.::||.||
  Rat    63 LATAELAGTEFVAEKLNIKFVPPEARTGLLSFEESQRIKRLHEENRQFLCIPRRPNWDRKTSPEE 127

  Fly   129 LVRAENEAFLDWRRDLALLQEDEEILMTPYEKNLEFWRQLWRVVERSDVVVQIVDARNPLLFRSA 193
            |.:||.:.||.|||.|..|:|::::::||:|:||:||||||||:||||:||||||||||||||..
  Rat   128 LKQAEKDNFLKWRRQLVRLEEEQKLILTPFERNLDFWRQLWRVIERSDIVVQIVDARNPLLFRCE 192

  Fly   194 DLERYVKEVEPSKMNMILVNKSDLLTEEQRRHWAEYFDSEGIRTAFYSATLVEEELKREAEECLD 258
            |||.||||::.:|.|:||:||:||||.|||..||.:|:.||::..|:||......|..::::.::
  Rat   193 DLECYVKEIDAAKENVILINKADLLTAEQRVAWAVHFEKEGVKVIFWSALAETVHLNGDSKDEVN 257

  Fly   259 SFPEVQQLRRAVEEIKQSLD-----------------------SVEDALNVIEQKYKTIPETQN- 299
            |   |.....:.|....|||                       ..||.....|:.::|..|..:
  Rat   258 S---VAGEANSSESEDSSLDGNEIPHRDLFLLSEESESDDDDSEYEDCQEDEEEDWQTCSEEDSN 319

  Fly   300 ------------DELPRLPGD--------------KNSPRLLSRLELIEFLRNIYTGPRHTEQHV 338
                        |:....|.|              .|...|:|:.||:|..:.::||.:..:..:
  Rat   320 PEEGQEEGGCDRDQKEHGPEDSEAQSRASPENSQMSNKSHLVSKQELLELFKKLHTGKKVKDGQL 384

  Fly   339 TVGMVGYPNVGKSSTINSLMTVKKVSVSATPGKTKRFQTLFLDKDILLCDCPGLVMPSFVLTKAD 403
            |||:|||||||||||||::|..||||||||||.||.||||:::..:.|||||||||||||.|||:
  Rat   385 TVGLVGYPNVGKSSTINTIMGNKKVSVSATPGHTKHFQTLYVEPGLCLCDCPGLVMPSFVSTKAE 449

  Fly   404 MLLNGILPIDQMRDHVPAVNLLCERIPRHVLEDKYGIVIAKPLEGEDMERPPHSEELLLAYGYNR 468
            |:.:|||||||||||||.|:|:|:.|||.|||..|||.|.||.|.||..|||.|||||.|||..|
  Rat   450 MICSGILPIDQMRDHVPPVSLVCQNIPRRVLEATYGINIIKPGEDEDPYRPPTSEELLTAYGCMR 514

  Fly   469 GFMTSNGQPDQARSARYVLKDYVNGRLLYAMSPPSVPQTEYHTFPERQRRVIEESQL-------- 525
            ||||::|||||.|||||:|||||.|:|||...||......:    :.|.|.:.|:::
  Rat   515 GFMTAHGQPDQPRSARYILKDYVRGKLLYCHPPPGKDPVAF----QHQHRQLLENKIKGEELRLQ 575

  Fly   526 PGQQQRAMRINKSTSKELDNQFFSDKPTHAHVKGRTNF----PNVRLANDGSLVAGNDPAAKPW- 585
            ||:.|:|    |.....:|..||..:...|..||....    |...|....:..|.|.| .|||
  Rat   576 PGKTQKA----KQVENVVDKTFFHQENVRALTKGVQAVMGYKPGSGLVTAAAASAENVP-GKPWK 635

  Fly   586 RHVKKERREKLRKKFSHLD 604
            :|..:.::||.|:.:.|||
  Rat   636 KHGNRNKKEKSRRLYRHLD 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ns3	NP_001284779.1	RbgA	161..524	CDD:224083	200/412 (49%)
		HSR1_MMR1	164..395	CDD:206750	118/280 (42%)
		p10	<270..312	CDD:177631	13/91 (14%)
		P-loop_NTPase	313..>357	CDD:304359	23/43 (53%)
Lsg1	NP_001013439.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		11/32 (34%)
		RbgA	151..551	CDD:224083	200/402 (50%)
		HSR1_MMR1	163..441	CDD:206750	118/280 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..359		15/108 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	625..655		13/31 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346099
Domainoid	1	1.000	293	1.000	Domainoid score	I1458
eggNOG	1	0.900	-	-		E1_COG1161
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5917
Inparanoid	1	1.050	550	1.000	Inparanoid score	I1091
OMA	1	1.010	-	-		QHG55394
OrthoDB	1	1.010	-	-		D206558at33208
OrthoFinder	1	1.000	-	-		FOG0004203
OrthoInspector	1	1.000	-	-		oto96232
orthoMCL	1	0.900	-	-		OOG6_101986
Panther	1	1.100	-	-	LDO	PTHR45709
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2947
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770