Protein Alignment Ns3 and GNL1

DIOPT Version :10

• Sequence 1: NP_569915.1
• Gene: Ns3 / 31097
• FlyBaseID: FBgn0266284
• Length: 606
• Species: Drosophila melanogaster
• Sequence 2: NP_005266.2
• Gene: GNL1 / 2794
• HGNCID: 4413
• Length: 607
• Species: Homo sapiens
• Alignment Length: 633
• Identity: 178/633 - (28%)
• Similarity: 276/633 - (43%)
• Gaps: 104/633 - (16%)

  Fly    18 KDRFGHTQRRKVDNDTMLHTTELQDGYDWGRLNLSSVTEESSFQAFLRTAELAGTEFQAEKLNIT 82
            |..|...|::|...|.......||||     |..||.:...|.:.  |..:...::.::...:|.
Human     4 KKPFSVKQKKKQLQDKRERKRGLQDG-----LRSSSNSRSGSRER--REEQTDTSDGESVTHHIR 61

  Fly    83 FVNPKQRVGLLSKTQEQRMHQKHDEH-------------RDQ----------------------- 111
            .:|.:...||..:..:...::.|.|.             |:|
Human    62 RLNQQPSQGLGPRGYDPNRYRLHFERDSREEVERRKRAAREQVLQPVSAELLELDIREVYQPGSV 126

  Fly   112 LKIPRRPKWTKETSAEELVRAENEAFLDWRRDLALLQEDEEILMTPYEKNLEFWRQLWRVVERSD 176
            |..||||.|:.|.|.|:|:..|..:|.|:...:......|:  ::.:|.|||.|||||||:|.||
Human   127 LDFPRRPPWSYEMSKEQLMSQEERSFQDYLGKIHGAYSSEK--LSYFEHNLETWRQLWRVLEMSD 189

  Fly   177 VVVQIVDARNPLLFRSADLERYVKEVEPSKMNMILV---NKSDLLTEEQRRHWAEYFDS------ 232
            :|:.|.|.|:|::.....|..||    ..::.:.||   ||.||........|..||..
Human   190 IVLLITDIRHPVVNFPPALYEYV----TGELGLALVLVLNKVDLAPPALVVAWKHYFHQHYPQLH 250

  Fly   233 --------EGIRTAFYSATLVEEELKREAEECLDSFPEVQQLRRAVEEI---KQSLDSVED--AL 284
                    ...||....::::::..:|.........||  ||.||.|.|   |..|.|..:  |.
Human   251 VVLFTSFPRDPRTPQDPSSVLKKSRRRGRGWTRALGPE--QLLRACEAITVGKVDLSSWREKIAR 313

  Fly   285 NVIEQKYKTIPETQNDELPRLPGDKNSPRLLSRLELIEFLRNIYTGP---RHTEQHVTVGMVGYP 346
            :|....:......:.:|       ::.|.:|...:....:..  |||   |:.:..||:|.||:|
Human   314 DVAGATWGNGSGEEEEE-------EDGPAVLVEQQTDSAMEP--TGPTQERYKDGVVTIGCVGFP 369

  Fly   347 NVGKSSTINSLMTVKKVSVSATPGKTKRFQTLFLDKDILLCDCPGLVMPSFVLTKADMLLNGILP 411
            ||||||.||.|:..|.||||.|||.|:.|||.||...:.|||||||:.|| :|.:...:|.||.|
Human   370 NVGKSSLINGLVGRKVVSVSRTPGHTRYFQTYFLTPSVKLCDCPGLIFPS-LLPRQLQVLAGIYP 433

  Fly   412 IDQMRDHVPAVNLLCERIPRHVLEDKYGIVIAKPLEGED--MERPPHSEELLLAYGYNRGFMTSN 474
            |.|:::...||..|..|||...|     :.:..| |.||  .|.|..:.::..|:...||:.|:.
Human   434 IAQIQEPYTAVGYLASRIPVQAL-----LHLRHP-EAEDPSAEHPWCAWDICEAWAEKRGYKTAK 492

  Fly   475 -GQPDQARSARYVLKDYVNGRLLYAMSPPSVPQTE--YHTFPERQRRVIEESQL--PGQQQRAMR 534
             .:.|..|:|..:|:..|:|||.....||...:.:  :.:.||....|:.:.::  .|.::....
Human   493 AARNDVYRAANSLLRLAVDGRLSLCFHPPGYSEQKGTWESHPETTELVVLQGRVGPAGDEEEEEE 557

  Fly   535 INKSTSKELDNQFFSDKPTHAHVKGRTNFPNVRLANDGSLVAGNDPAA 582
            ...|:|.|.:.:  .|:......:|....|.   :..||.:||.:|.|
Human   558 EELSSSCEEEGE--EDRDADEEGEGDEETPT---SAPGSSLAGRNPYA 600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ns3	NP_569915.1	HSR1_MMR1	164..395	CDD:206750	86/255 (34%)
		RbgA	176..495	CDD:440775	109/346 (32%)
GNL1	NP_005266.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..81		18/83 (22%)
		RbgA	173..514	CDD:440775	121/362 (33%)
		HSR1_MMR1	177..418	CDD:206750	86/255 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	547..607		13/59 (22%)