DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ns3 and GNL3

DIOPT Version :9

Sequence 1:	NP_001284779.1	Gene:	Ns3 / 31097	FlyBaseID:	FBgn0266284	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_055181.3	Gene:	GNL3 / 26354	HGNCID:	29931	Length:	549	Species:	Homo sapiens

Alignment Length:	588	Identity:	127/588 - (21%)
Similarity:	215/588 - (36%)	Gaps:	182/588 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RQLIKD--RFGHTQRRKVDNDTMLHTTELQDGYDWGRLNLSSVTEESSFQAFLRTAELAGTEFQA 76
            |:|.|:  :.||.:.||                |.|..|.:...|     |.||.|||.
Human    30 RKLRKEAKKRGHKKPRK----------------DPGVPNSAPFKE-----ALLREAELR------ 67

  Fly    77 EKLNITFVNPKQRVGLLSKTQEQRMHQKHDEHRD---QLKIPRRPKWTKETSAEELVRAENEAFL 138
                      |||:      :|.:..||.|..::   :.|:...|. .|.::.|.:
Human    68 ----------KQRL------EELKQQQKLDRQKELEKKRKLETNPD-IKPSNVEPM--------- 106

  Fly   139 DWRRDLALLQEDEEILMTPYEKNLEFWRQLWRVVERSDVVVQIVDARNPLLFRSADLERYVKEVE 203
              .::..|.:.:.:...........:.::|.:|:|.||||::::|||:||..|...:|..:.:..
Human   107 --EKEFGLCKTENKAKSGKQNSKKLYCQELKKVIEASDVVLEVLDARDPLGCRCPQVEEAIVQSG 169

  Fly   204 PSKMNMILVNKSDLLTEEQRRHWAEYFDSEGIRTAFYSATLVEEELKREAEECLDSFPEVQQLRR 268
            ..|:.:|| |||||:.:|....|..|                   ||:|
Human   170 QKKLVLIL-NKSDLVPKENLESWLNY-------------------LKKE---------------- 198

  Fly   269 AVEEIKQSLDSVEDALNVIEQKYKTIPETQNDELPRLPGDKNSPRLLSRLELI---EFLRNIYTG 330
                           |..:..:..|.|:.:.....|:...||:...  |.|:.   |.|..:..|
Human   199 ---------------LPTVVFRASTKPKDKGKITKRVKAKKNAAPF--RSEVCFGKEGLWKLLGG 246

  Fly   331 PRHT-EQHVTVGMVGYPNVGKSSTINSLMTVKKVSVSATPGKTKRFQTLFLDKDILLCDCPGLVM 394
            .:.| .:.:.||::|:|||||||.||||...:..:|..:.|.|:..|.:.|||.|.:.|     .
Human   247 FQETCSKAIRVGVIGFPNVGKSSIINSLKQEQMCNVGVSMGLTRSMQVVPLDKQITIID-----S 306

  Fly   395 PSFVLTKADMLLNGILPIDQMRDHVPAVNLLCERIPRHVLEDKYGIVIAKPLEGED-MERPPHSE 458
            |||:::          |::       :.:.|..|.|.       .|.:.||:|... :.....:.
Human   307 PSFIVS----------PLN-------SSSALALRSPA-------SIEVVKPMEAASAILSQADAR 347

  Fly   459 ELLLAY---GY------------NRGFMTSNGQPDQARSARYVLKDYVNGRLLYAMSPPSVPQTE 508
            :::|.|   ||            .||.....|.|:...:|:.:..::....|.|...||    |.
Human   348 QVVLKYTVPGYRNSLEFFTVLAQRRGMHQKGGIPNVEGAAKLLWSEWTGASLAYYCHPP----TS 408

  Fly   509 YHTFPERQRRVIEE-------SQLPGQQQRAMRINKS---------TSKELDNQFFSDKPTHAHV 557
            :...|.....::.:       .:|.....:::|..|.         .|..|.|....:|..|..:
Human   409 WTPPPYFNESIVVDMKSGFNLEELEKNNAQSIRAIKGPHLANSILFQSSGLTNGIIEEKDIHEEL 473

  Fly   558 KGR 560
            ..|
Human   474 PKR 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ns3	NP_001284779.1	RbgA	161..524	CDD:224083	89/389 (23%)
		HSR1_MMR1	164..395	CDD:206750	63/234 (27%)
		p10	<270..312	CDD:177631	6/41 (15%)
		P-loop_NTPase	313..>357	CDD:304359	18/47 (38%)
GNL3	NP_055181.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56		10/41 (24%)
		Basic. /evidence=ECO:0000250	2..46		5/15 (33%)
		GN3L_Grn1	16..85	CDD:285863	24/97 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	73..104		7/31 (23%)
		RbgA	133..419	CDD:224083	89/371 (24%)
		Nucleostemin_like	142..307	CDD:206753	59/222 (27%)
		Intermediate. /evidence=ECO:0000250	282..456		38/206 (18%)
		Acidic. /evidence=ECO:0000250	465..543		3/12 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	474..532		1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810