Protein Alignment Ns3 and Lsg1

DIOPT Version :10

• Sequence 1: NP_569915.1
• Gene: Ns3 / 31097
• FlyBaseID: FBgn0266284
• Length: 606
• Species: Drosophila melanogaster
• Sequence 2: NP_001403957.1
• Gene: Lsg1 / 224092
• MGIID: 107236
• Length: 650
• Species: Mus musculus
• Alignment Length: 657
• Identity: 317/657 - (48%)
• Similarity: 412/657 - (62%)
• Gaps: 61/657 - (9%)

  Fly     1 MGKKNKGGAPNLGRQLIKDRFGHTQRRKV--DNDTMLHTTELQDGYDWGRLNLSSVTEESSFQAF 63
            ||::...|..:|||.||:.:   |||.:.  ..|:.|||:||.||||||||||.||||:||.:.|
Mouse     1 MGRRRAPGGGSLGRVLIRQQ---TQRSRSHRHTDSWLHTSELNDGYDWGRLNLQSVTEQSSLEDF 62

  Fly    64 LRTAELAGTEFQAEKLNITFVNPKQRVGLLSKTQEQRMHQKHDEHRDQLKIPR------RPKWTK 122
            |.|||||||||.||||||.||.|:.|.||||..:.||:.:.|:|:|..|.|||      ||.|.:
Mouse    63 LATAELAGTEFVAEKLNIKFVPPEARTGLLSFEESQRIKKLHEENRQFLCIPRSFYDCFRPNWDR 127

  Fly   123 ETSAEELVRAENEAFLDWRRDLALLQEDEEILMTPYEKNLEFWRQLWRVVERSDVVVQIVDARNP 187
            :||.|||.:||.:.||.|||.|..|:|::::::||:|:||:||||||||:||||:||||||||||
Mouse   128 KTSPEELKQAEKDNFLKWRRQLVRLEEEQKLILTPFERNLDFWRQLWRVIERSDIVVQIVDARNP 192

  Fly   188 LLFRSADLERYVKEVEPSKMNMILVNKSDLLTEEQRRHWAEYFDSEGIRTAFYSATLVEEELKRE 252
            ||||..|||.||||::.:|.|:||:||:||||.|||..||.:|:.||::..|:||....:.|..:
Mouse   193 LLFRCEDLECYVKEIDAAKENVILINKADLLTAEQRFAWAVHFEKEGVKVIFWSALAETDHLNGD 257

  Fly   253 AEECLDS-------------------FPEVQQLRRAVEEIKQSLDS-VEDALNVIEQKYKT---- 293
            .:|.:||                   .|....:..:.|....|.|| .||.....|:.::|
Mouse   258 LKEEVDSVAGDTNKTESESSSLDANEIPHRDLISLSEESASDSGDSKYEDCQEDEEEDWQTCSEE 322

  Fly   294 --IP----------ETQNDELPRLPGDKNSPRLLSRLELIEFLRNIYTGPRHTEQHVTVGMVGYP 346
              :|          ||||.:........|...|:|:.||:|..:.::||.:..:..:|||:||||
Mouse   323 DSVPEEEEGCNADSETQNRKNAENQQVNNDSYLVSKQELLELFKKLHTGKKVKDGQLTVGLVGYP 387

  Fly   347 NVGKSSTINSLMTVKKVSVSATPGKTKRFQTLFLDKDILLCDCPGLVMPSFVLTKADMLLNGILP 411
            |||||||||::|..||||||||||.||.||||:::..:.|||||||||||||.|||:|:.|||||
Mouse   388 NVGKSSTINTIMGNKKVSVSATPGHTKHFQTLYVEPGLCLCDCPGLVMPSFVSTKAEMICNGILP 452

  Fly   412 IDQMRDHVPAVNLLCERIPRHVLEDKYGIVIAKPLEGEDMERPPHSEELLLAYGYNRGFMTSNGQ 476
            |||||||||.|:|:|:.|||.|||..|||.|.||.|.||..|||.|||||.|||..|||||::||
Mouse   453 IDQMRDHVPPVSLVCQNIPRRVLEVTYGINIIKPREDEDPYRPPTSEELLTAYGCMRGFMTAHGQ 517

  Fly   477 PDQARSARYVLKDYVNGRLLYAMSPPSVPQTEYHTFPERQRRVIEESQLPGQQQRAM----RINK 537
            |||.|||||:|||||.|:|||...||......:    :.|.:.:.||::.|.:.|..    |..|
Mouse   518 PDQPRSARYILKDYVGGKLLYCHPPPGKDPVAF----QHQHQQLLESKVKGGELRLQPGKGRKAK 578

  Fly   538 STSKELDNQFFSDKPTHAHVKGRTNF----PNVRLANDGSLVAGNDPAAKPW-RHVKKERREKLR 597
            .....:|..||..:...|..||....    |...|....:..|.|.| .||| :|..:.::||.|
Mouse   579 QIENVVDKTFFHQENVRALTKGVQAVMGYKPGHGLVTAAAASAENVP-GKPWKKHGNRNKKEKSR 642

  Fly   598 KKFSHLD 604
            :.:.|||
Mouse   643 RLYKHLD 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ns3	NP_569915.1	HSR1_MMR1	164..395	CDD:206750	121/266 (45%)
		RbgA	176..495	CDD:440775	183/354 (52%)
Lsg1	NP_001403957.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		11/32 (34%)
		HSR1_MMR1	169..436	CDD:206750	121/266 (45%)
		RbgA	181..536	CDD:440775	183/354 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	259..351		17/91 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	624..650		11/27 (41%)