Protein Alignment Ns3 and ngp-1

DIOPT Version :10

• Sequence 1: NP_569915.1
• Gene: Ns3 / 31097
• FlyBaseID: FBgn0266284
• Length: 606
• Species: Drosophila melanogaster
• Sequence 2: NP_492275.2
• Gene: ngp-1 / 172624
• WormBaseID: WBGene00003596
• Length: 651
• Species: Caenorhabditis elegans
• Alignment Length: 676
• Identity: 149/676 - (22%)
• Similarity: 258/676 - (38%)
• Gaps: 189/676 - (27%)

  Fly    17 IKDRFGHTQRRKVDNDTMLHTTE--LQDGYDW-GRLNLSSVTEESSFQAFLRTAELAGTEFQAEK 78
            |:|..|...:.....||:...|:  ::....| |...:....:...|||.|  .::....||
 Worm    67 IRDSKGKILKAAPFQDTLASGTQARIEPNRKWFGNTRIIGQEQLQKFQANL--GKVLSDPFQ--- 126

  Fly    79 LNITFVNPKQRVGLL-SKTQEQRMHQKHDEHRD----QLKIPRRPKWTKETSAEELVRAENEAFL 138
              :.....|..:.|| .|.:.||:|....|..:    :..:.::.|.| |.|.||:.::..:..:
 Worm   127 --VVMKQTKLPISLLQEKAKTQRVHVTETESFEYTFGKKSLRKKAKLT-EASLEEMSKSAEDRDV 188

  Fly   139 DWRRDLALLQEDEEILMTPYEKNLEF--------WRQLWRVVERSDVVVQIVDARNPLLFRSADL 195
            .::.:|.|.:| :|:...|...|..|        |.:|::|::.||||||:||||:|:..|...:
 Worm   189 KYKPELDLSRE-KELGDRPENMNPLFRAGQSNRVWGELYKVIDSSDVVVQVVDARDPMGTRCRHV 252

  Fly   196 ERYVKEVEPSKMNMILVNKSDLLTEEQRRHWAEYFDSEGIRTAFYSATLVEEELKREAEECLDSF 260
            |.::::.:|.|..:.::||.||:.....|.|......|....||:::  :.....:.|
 Worm   253 EEFLRKEKPHKHLVTVINKVDLVPTWVTRKWIGELSKEMPTIAFHAS--INNSFGKGA------- 308

  Fly   261 PEVQQLRRAVEEIKQSLDSVEDALNVIEQKYKTIPETQNDELPRLPGDKNSPRLLSRLELIEFLR 325
                                  .:|::.|..|..|:
 Worm   309 ----------------------VINLLRQFAKLHPD----------------------------- 322

  Fly   326 NIYTGPRHTEQHVTVGMVGYPNVGKSSTINSLMTVKKVSVSATPGKTKRFQTLFLDKDILLCDCP 390
                     ...::||.:|||||||||.:|:|...|....:...|:||.:|.:.|.:.|.|.|.|
 Worm   323 ---------RPQISVGFIGYPNVGKSSLVNTLRKKKVCKTAPIAGETKVWQYVMLMRRIYLIDSP 378

  Fly   391 GLVMPSFVLTKADMLLNGILPIDQMRD---HVPAVNLLCERIPRHVLEDKYGIVIAKPLEGEDME 452
            |:|.|... ::..::|.|::.::.::|   ||..|...|:  |.| |..:|||.     |..|:
 Worm   379 GVVYPQGD-SETQIILKGVVRVENVKDPENHVQGVLDRCK--PEH-LRRQYGIP-----EFTDV- 433

  Fly   453 RPPHSEELLLAYGYNRGFMTSNGQPDQARSARYVLKDYVNGRLLYAMSPPSVPQ---TEYHTFPE 514
                 ::.|......:|.:...|.||....::.||.::..|:|.|.:.||...:   .::...|.
 Worm   434 -----DDFLTKIAIKQGRLLKGGDPDIVAVSKVVLNEFQRGKLPYFVPPPGCEERAKKDFSQAPI 493

  Fly   515 RQRRVIEESQLP--------------------------GQQQRAMRINKSTSKELDNQFFSD--- 550
            .:....::.|||                          .:|:....|..:.|...|....||
 Worm   494 NEMCADDDEQLPLDAQLELDDVARNGGPDEDDDEAIDDEEQEELTEIGSTCSGLTDLSGISDLAG 558

  Fly   551 -------------KPTHAH---VKGRTNFPNVRL--------AN-----------------DGSL 574
                         ||:.:.   .|.:|:..:||.        ||                 |.|:
 Worm   559 DLSDADDVADDDEKPSSSDSKTKKSKTDVASVRTRGKRGGKKANKAKLSGKTIVQAASEKKDKSV 623

  Fly   575 VAGNDPAA---KPWRHVKKERREKLR 597
            |....|.|   ..||. |.|:|.|::
 Worm   624 VEFAKPGATKTNMWRK-KLEKRRKVK 648

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ns3	NP_569915.1	HSR1_MMR1	164..395	CDD:206750	58/238 (24%)
		RbgA	176..495	CDD:440775	77/321 (24%)
ngp-1	NP_492275.2	NGP1NT	60..190	CDD:462379	28/130 (22%)
		NGP_1	224..380	CDD:206751	54/224 (24%)
		P-loop containing Nucleoside Triphosphate Hydrolases	329..461	CDD:476819	45/146 (31%)