Protein Alignment Ns3 and Ns4

DIOPT Version :10

• Sequence 1: NP_569915.1
• Gene: Ns3 / 31097
• FlyBaseID: FBgn0266284
• Length: 606
• Species: Drosophila melanogaster
• Sequence 2: XP_317131.5
• Gene: Ns4 / 1277654
• VectorBaseID: AGAMI1_014625
• Length: 587
• Species: Anopheles gambiae
• Alignment Length: 618
• Identity: 188/618 - (30%)
• Similarity: 283/618 - (45%)
• Gaps: 104/618 - (16%)

  Fly     2 GKKNKGGAPNLGRQLIKDRFGHTQRRKVDNDTMLHTTELQD-----GYDWGRLNLS------SVT 55
            ||:.|  ...|.::..|....|...|.:.::.....:|..|     |.:..::||.      |.|
Mosquito    12 GKQKK--QQLLAKKQAKSSTSHNLIRNLKDEESSDISEDSDMPRTFGQNIEKINLQPLKDPRSKT 74

  Fly    56 EESSFQAFLRTA-ELAGTEFQAEKLNITFVNPKQRVGLLSKTQEQRMHQKHDEHRDQLKIPRRPK 119
            .....|....|| ||...:.:|.|            ||:.:: ||.| :..|.:..|...|.|||
Mosquito    75 NRYVLQFHRETAKELREMKEEARK------------GLVYRS-EQEM-ELGDNYFQQYDFPTRPK 125

  Fly   120 WTKETSAEELVRAENEAFLDWRRDLALLQEDEEILMTPYEKNLEFWRQLWRVVERSDVVVQIVDA 184
            ||.|.|.|:|...||..|..:...|.....|:...::..|.|||.|||||||:|.||:|:.||||
Mosquito   126 WTYEMSKEQLDGNENRYFFKYVTKLEKDHYDDMKSLSFCELNLETWRQLWRVLELSDIVLIIVDA 190

  Fly   185 RNPLLFRSADLERYVKEVEPSKMNMILVNKSDLLTEEQRRHWAEYFDSE------GIRTAFYSAT 243
            |.|.|.....|.:||.| |..|..|:::||.||:..|....|..||:.:      .:.|::.|..
Mosquito   191 RFPTLMFPPALYKYVTE-ELGKGMMLVINKIDLVEAEAVLAWKRYFEQKYPHIHVVLFTSYPSYN 254

  Fly   244 LVEEELKREAEECLDSFPEVQQLRRAVEEIKQSLD------SVEDALNVIEQKYKTIPETQNDEL 302
            |   ..|:|::..|.......::|.|.|..:|..|      ..|..|...|||   |.|.:|..:
Mosquito   255 L---RGKQESKYGLKIRRRRGRMRMAAEGAQQIYDICHKYVGDEVDLGSWEQK---ILEERNAPM 313

  Fly   303 PRLPGDKNSPRLLSRL--ELIEFLRNIYTGPRHTEQHV-------TVGMVGYPNVGKSSTINSLM 358
             .:.||::...:..|.  |..:|.         .|:||       |:|.||||||||||.:|::|
Mosquito   314 -EVDGDEDKKLVSERTHEEEKDFA---------FEEHVKFKNGVLTIGCVGYPNVGKSSLLNAVM 368

  Fly   359 TVKKVSVSATPGKTKRFQTLFLDKDILLCDCPGLVMPSFVLTKADMLLNGILPIDQMRDHVPAVN 423
            ..|.||||.|||.||.|||:||...:.||||||||.||....:..:|: |..||.|:|:...::.
Mosquito   369 GRKVVSVSRTPGHTKHFQTIFLTNTVRLCDCPGLVFPSSTPRRLQVLM-GSYPIAQLREPYASIR 432

  Fly   424 LLCERIPRHVLEDKYGIVIAKPLEGEDMERPPHSEELLLAYGYNRGFMTSN-GQPDQARSARYVL 487
            .|.||:      |...::..|..|.::.|.  .:.::..|:...|||:|:. .:||..|:|..:|
Mosquito   433 FLAERL------DLVRLLSLKHPESDNDEW--SAIDICDAWAIKRGFLTAKAARPDTYRAANSIL 489

  Fly   488 KDYVNGRLLYAMSPPSVPQTEYHTFPERQRRVIEESQL---PG--QQQRAMRINKSTSKELDNQF 547
            :..::|::..::.|     ..||         :|:.:|   ||  :.:....|.::...:.::..
Mosquito   490 RMALDGKITLSLKP-----IGYH---------LEKEKLATDPGLARVKEIQAIVENDGNDDEDDC 540

  Fly   548 FSDKPTHAHVKGRTNFPNVRLANDGSLVAGNDP 580
            |||..|. .:.|        .:|||......||
Mosquito   541 FSDTDTE-DMAG--------ASNDGDNEEDEDP 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ns3	NP_569915.1	HSR1_MMR1	164..395	CDD:206750	97/251 (39%)
		RbgA	176..495	CDD:440775	114/340 (34%)
Ns4	XP_317131.5	None