DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrpprc2 and lrpprc

DIOPT Version :9

Sequence 1:	NP_569913.1	Gene:	Lrpprc2 / 31095	FlyBaseID:	FBgn0027794	Length:	1072	Species:	Drosophila melanogaster
Sequence 2:	NP_001039203.1	Gene:	lrpprc / 734062	XenbaseID:	XB-GENE-1014657	Length:	1391	Species:	Xenopus tropicalis

Alignment Length:	1097	Identity:	241/1097 - (21%)
Similarity:	463/1097 - (42%)	Gaps:	157/1097 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SASLA-FRYATKPAAPAVPFSLLQMRSLGTGGVLS--------AVERRS---RRPASSSEKPKAS 79
            ||.|| .|:..:|...|:|...::: |.|.|..|:        |.:::.   ..|.|:....:|.
Frog     2 SALLAGARFLLRPGLRALPAPCVRL-SPGQGRYLNNTPGHFAIAAQQKGHIHEEPVSAVRAKQAQ 65

  Fly    80 VAD-AWTQLEAYYRQHDLINFEHCQRLLELLQESASPLGVGIEEVHFLLGSCVPELLPAQSSQER 143
            ..| |..:|::..|:...|.....|::...:..:..|   ...:...||.|| ..|||.....||
Frog    66 QFDWALNKLDSSVRRTGRITKTLLQKIFHDVCRTGYP---SSNQALLLLRSC-GSLLPELQMSER 126

  Fly   144 LQLFKGLWAQLIKLGQP-TLAHYHTKLQVLRQN--RLPLTDYRSLLAEIAVYHGAADSTLYGALL 205
            .::...:|.:|.:||.. .::||:..|:|..||  :...|:|   ||::...:...:...|..|:
Frog   127 TEMAHRIWEKLQELGAVFDVSHYNALLKVYLQNEHKFSPTEY---LAKMEAANVQPNRVTYQRLI 188

  Fly   206 DVAGAAGNMRMATEILSEMRERSLALTEHNFHALLLGHARSGDLPGAESVLASMRAAGIQQGSST 270
            ......|::..|::||..|:.:.|.:||..|:.|:.||||:||:..|:::|:.||:|||:.|..|
Frog   189 AAYCNEGDIEGASKILGFMKNKDLPITEAVFNTLVTGHARAGDMENAKNILSVMRSAGIEPGPET 253

  Fly   271 QAIWFEALLENGQLAQAKELLQ----VEHGFTAPQLLQMLRGLLASKDVDTDLIQLLVKEL--PR 329
            ......|..|.|.:...|:.|:    .|...|...|:|::..|  :|......:|.:|:.:  .|
Frog   254 YVALLTAYAEKGDINNIKQTLENVEKNEGSLTDRDLMQVIWSL--AKAGYPQYVQDIVERMRYDR 316

  Fly   330 EFLTGIDLPPAIRSLCIQLVHQGRTEVVIQLVGALPAPKFELQNQNVDEYGALLLQEFFRAQVPL 394
            .::      |...:||:.|:.||..:|...::.:..|...:..|.:...:|...|:.......|.
Frog   317 GYI------PDAMNLCLSLMTQGFEDVAFLVLKSFSAASHDSPNGDSLHHGNFFLRHCVNLDKPA 375

  Fly   395 DQTIQFAGQLVQRNQNVRALHLVAELAL-RRQPSSALRCLEDLSAAGEELRPHYFWPLILHHYRR 458
            ::..||...|.:.|.:...|......:| .::...||..::.:...|..:||||.|||::...:.
Frog   376 NKVKQFCDGLKEENLHSAPLQFALYCSLDAKKADLALELMKMMKQEGMPVRPHYCWPLLISFQKE 440

  Fly   459 EGESGMLRLVSEMRRLRVECDEETLRHYLFPHLRQTLVQPLEAVKALESAGVKPSQTLCPVVS-- 521
            :...|.::::..:..:.||.|.||..:|:           |.....::||..:..:..|.|.|
Frog   441 KNAEGTIKVIKALSEIGVELDVETYSNYV-----------LSVFNDVKSARAQLQEHGCTVDSSW 494

  Fly   522 -------HLLQQHQMSEVLDLLD--RYPTRLDLATLLQPLSSLAVNARATKRFEVFAKVIQALQQ 577
                   |......:.||..||.  .:|: :||...   ..||....:.:...::.||:.:.|.:
Frog   495 FNLAELRHDAVSGNLEEVYSLLSSPSFPS-VDLGHF---RGSLITAFKRSNNVDLKAKITELLYK 555

  Fly   578 -----KALKRGEDFVG----SLLLQMTGPQTRLRQDATSLRRFLHELRRLELQISPAASEALLSV 633
                 :|.....:.||    :|:..|:..:.:.:::  .||::.|:|:...:.||......:.::
Frog   556 DGRYCQAASGPNEAVGYFLYNLIDSMSDAEVQAKEE--HLRQYFHQLKNANIVISANIYRGIRNL 618

  Fly   634 V--RHATD---DVDLIQDLAKTLQKMKNPQLA-LPADTVSLHGGFIKHPRDMSIDELECHLVELE 692
            :  .|..:   ||.::.|..:||......:.| |.|.|:                |.|...::.|
Frog   619 LDSSHVPELIKDVIVLVDSQETLTSSDIAKSAELKASTL----------------EEEIETLKAE 667

  Fly   693 SKQLNPRG-VLRRLLQLSVRSGRLERAQQLLAKCQVLKVQE--SAGMMASIFDLHIKLRDLPRAQ 754
            :|   |.| ||::|:.:......:::|.::.||.:    ||  :.|..|::..|..:..:...|.
Frog   668 NK---PFGDVLKQLVMIHCSEENMQKALEVKAKYE----QENLAIGTYAALIQLCCRHDNPDEAL 725

  Fly   755 ESLERLSSMYPAFQIDEHKVIDYAALLVQGQQLEAAKQLLQRRAEQHKVVGGDYVMK-----NVW 814
            ...:.|:....:..:|..|.:....:..:..::..|..:|:...|:      |..:|     :.:
Frog   726 NLKQELNRKDSSAVLDTSKYLALVKVFGKNGRIADAINVLKEMKEK------DVPLKETTTTSFF 784

  Fly   815 QLLTNVGQLAASSHAGGESSKQLNQTREWLDFLRGLGYCQSQNALLGPVVREWLLKGNLDAAVAE 879
            .:|.     ||:.....|:..:::::      :..||..:..:.|..|:|...|.||:|.||:..
Frog   785 HILN-----AAALRGDAETVDKIHES------IVTLGLAKPTSNLCSPLVSVHLEKGDLPAAMET 838

  Fly   880 FQRLANTHKHTPLQFELLSLLVRLGNGDEQELTRFPGVTAESAQQHLAVVTATVSRIHGAANMNS 944
            ....:..:...|...::|..||..|:.|          ..:.|..|       :|:..|...|..
Frog   839 LFTCSKKYNCMPRLHDVLCRLVEKGDTD----------LLQKAMDH-------ISQERGEMAMLY 886

  Fly   945 ALLLALAESGKETQLRRLIINPEFRINH---ELLVKNCEHLGQEGAVRTLLRLARGVRGVQRTID 1006
            .||.|...:||..:.|::|..|..|...   :...:.|....|..|:..|:.:.:.:....|  |
Frog   887 DLLFAFLHTGKYKEARKIIETPGLRARPGRLQWFAEKCIATNQMEALENLVDMTQKLFECDR--D 949

  Fly  1007 EQKIYDLLLAQFCRSN-DYEAALDLFERLEADDELKVSHEFLRNLVQLLQVNQVEIP 1062
            :...|   |.:.|:.| |::.|...:.:::.::.:. ....||.|..:.:.|..|:|
Frog   950 DMYYY---LLKLCKENDDWKKADSAWTKIQEENVIP-RERTLRLLADIFRRNGQEVP 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrpprc2	NP_569913.1	PLN03218	<197..>292	CDD:215636	31/94 (33%)
		PPR repeat	201..227	CDD:276811	7/25 (28%)
		PPR repeat	233..262	CDD:276811	13/28 (46%)
		PPR repeat	268..292	CDD:276811	5/23 (22%)
lrpprc	NP_001039203.1	PPR 1	110..144		13/34 (38%)
		PPR repeat	113..140	CDD:276811	9/27 (33%)
		PPR_2	145..193	CDD:289786	12/50 (24%)
		PPR 2	145..179		10/36 (28%)
		PPR repeat	148..175	CDD:276811	10/29 (34%)
		PPR_1	176..208	CDD:289614	6/31 (19%)
		PPR_2	179..228	CDD:289786	14/48 (29%)
		PPR 3	180..214		8/33 (24%)
		PPR repeat	183..210	CDD:276811	7/26 (27%)
		PPR 4	215..249		17/33 (52%)
		PPR repeat	216..245	CDD:276811	13/28 (46%)
		PPR	218..249	CDD:273253	15/30 (50%)
		PPR 5	250..284		8/33 (24%)
		PPR repeat	251..280	CDD:276811	6/28 (21%)
		PPR 6	389..425		6/35 (17%)
		PPR repeat	678..701	CDD:276811	4/26 (15%)
		PPR 7	704..738		5/33 (15%)
		PPR repeat	707..734	CDD:276811	4/26 (15%)
		PPR 8	741..775		6/39 (15%)
		PPR repeat	742..771	CDD:276811	3/28 (11%)
		PPR 9	779..813		6/44 (14%)
		PPR repeat	780..807	CDD:276811	4/37 (11%)
		PPR 10	815..850		9/34 (26%)
		PPR 11	948..982		8/38 (21%)
		PPR 12	1028..1062
		PPR repeat	1036..1058	CDD:276811
		PPR 13	1063..1093
		PPR repeat	1064..1095	CDD:276811
		PPR 14	1100..1134
		PPR repeat	1101..1129	CDD:276811
		RNA-binding. /evidence=ECO:0000250	1118..1387
		PPR repeat	1136..1164	CDD:276811
		PPR repeat	1173..1198	CDD:276811
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D64969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46669
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020