DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrpprc2 and Lrpprc

DIOPT Version :9

Sequence 1:	NP_569913.1	Gene:	Lrpprc2 / 31095	FlyBaseID:	FBgn0027794	Length:	1072	Species:	Drosophila melanogaster
Sequence 2:	NP_082509.2	Gene:	Lrpprc / 72416	MGIID:	1919666	Length:	1392	Species:	Mus musculus

Alignment Length:	1094	Identity:	243/1094 - (22%)
Similarity:	466/1094 - (42%)	Gaps:	172/1094 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 AAPAVPFSLLQMRSLGTGGVLSAVERRS---RRPASS------------------SEKP----KA 78
            |||.:|.||  ....|..|.||:|.|.:   .|||:.                  .|:|    |.
Mouse    16 AAPRLPLSL--RLPAGVPGRLSSVVRVAAVGSRPAAGERLSQARLYAIVAEKRDLQEEPAPVRKN 78

  Fly    79 SVADAWT--QLEAYYRQHDLINFEHCQRLLELLQESASPLGVGIEEVHFLLGSCVPELLPAQSSQ 141
            |....|.  :|:...|:...|.....||:.|....|.||   |..:...||.|| ..|||..|..
Mouse    79 SSQFDWALMRLDNSVRRTGRITKGLLQRVFESTCSSGSP---GSNQALLLLRSC-GSLLPELSLA 139

  Fly   142 ERLQLFKGLWAQLIKLGQP-TLAHYHTKLQVLRQN--RLPLTDYRSLLAEIAVYHGA---ADSTL 200
            ||.:....:|.:|.:||.. .::||:..|:|..||  :...||:      :|...||   .:...
Mouse   140 ERTEFAHKIWDKLQQLGVVYDVSHYNALLKVYLQNEYKFSPTDF------LAKMEGANIQPNRVT 198

  Fly   201 YGALLDVAGAAGNMRMATEILSEMRERSLALTEHNFHALLLGHARSGDLPGAESVLASMRAAGIQ 265
            |..|:......|::..|::||..|:.:.|.:||..|.||:.||||:||:..||::|..|:.|||:
Mouse   199 YQRLIAAYCNVGDIEGASKILGFMKTKDLPITEAVFSALVTGHARAGDMENAENILTVMKQAGIE 263

  Fly   266 QGSSTQAIWFEALLENGQLAQAKELLQ----VEHGFTAPQLLQMLRGLLASKDVDTDLIQLLVKE 326
            .|..|......|..|.|.:.|.:::|:    .:|.|.....||::...  ||......:..::::
Mouse   264 PGPDTYLALLNAHAERGDIGQVRQILEKVEKSDHYFMDRDFLQVIFSF--SKAGYPQYVSEILEK 326

  Fly   327 LPREFLTGIDLPPAIRSLCIQLVHQGRTEVVIQLVGALPAPKFELQNQNVDEYGALLLQEFFRAQ 391
            :..|..:   :|.|: :|.:.|..:...:...|::.|||..|    :::.|.:|:..|:......
Mouse   327 ITYERRS---IPDAM-NLILFLATEKLEDTAFQVLLALPLSK----DESSDNFGSFFLRHCVTLD 383

  Fly   392 VPLDQTIQFAGQLVQRNQNVRALHLVAELALR-RQPSSALRCLEDLSAAGEELRPHYFWPLILHH 455
            :|.::.|.:..:|.....:..:|......||: .:.:.|...:|.|...|..:||||||||:..|
Mouse   384 LPPEKLIDYCRRLRDAKLHSSSLQFTLHCALQANRTALAKAVMEALREEGFPIRPHYFWPLLAGH 448

  Fly   456 YRREGESGMLRLVSEMRRLRVECDEETLRHYLFPHLRQTLVQPLEAVKALESAGVKPSQTLCPVV 520
            .:.:...|::.::..|.::.|:.|:||..:|:||           ...:.:|......:..|.:.
Mouse   449 QKTKNVQGIIDILKIMNKVGVDPDQETYINYVFP-----------CFDSAQSVRAALQENECLLA 502

  Fly   521 SHLLQQHQ---------MSEVLDLLDRYPTRLDLATLLQPLSSLAVNARATKRFEVFAKVIQALQ 576
            |....|.:         :..:|..|:........::|   .:||.:..|.:...::::|:.:.|.
Mouse   503 SSTFAQAEVKNEAINGNLQNILSFLESNTLPFSFSSL---RNSLILGFRRSMNIDLWSKITELLY 564

  Fly   577 QKALKRGED---------FVGSLLLQMTGPQTRLRQDATSLRRFLHELRRLELQISPAASEALLS 632
            :......:.         |:.:|:..|:..:.:.:::  .||::.|:|:.:.:::.....:.:.:
Mouse   565 KDERYCSKPPGPAEAVGYFLYNLIDSMSDSEVQAKEE--RLRQYFHQLQEMNVKVPENIYKGICN 627

  Fly   633 VVR--HATDDVDLIQDLAKTLQKMKNPQLALPADTVSLHGGFIKHPRDMSIDELECHLVELESKQ 695
            ::.  |..   :||:|:...:.:.|       .|:        :....::..:||..|.:|:::.
Mouse   628 LLNTYHVP---ELIKDIKVLVDREK-------VDS--------QKTSQVTSSDLESTLEKLKAEG 674

  Fly   696 LNPRGVLRRLLQLSVRSGRLERAQQLLAKCQVLKVQESAGMMASIFDL---HIKLRDLPRAQESL 757
            ......|::||.|......:::|.::.||.:...|   .|..|::.:|   |....|....::.:
Mouse   675 QPVGSALKQLLLLLCSEENMQKALEVKAKYESDMV---IGGYAALINLCCRHDNAEDAWNLKQEV 736

  Fly   758 ERLSSMYPAFQIDEHKVIDYAALLVQGQQLEAAKQLLQRRAEQHKVVGGDYVMKNVWQLLTNV-- 820
            :||.:   :..:|..|.:....:|.:..:|:.|..:|:...|:..|: .|..:.:.:.:|...
Mouse   737 DRLDA---SAILDTAKYVALVKVLGKHSRLQDAINILKEMKEKDVVI-KDATVLSFFHILNGAAL 797

  Fly   821 -GQLAASSHAGGESSKQLNQTREWLDFLRGLGYCQSQNALLGPVVREWLLKGNLDAAVAEFQRLA 884
             |::        |:.|||::.      :..||..:..:.:..|:|...|.||:|.||:.......
Mouse   798 RGEI--------ETVKQLHEA------IVTLGLAKPSSNISFPLVTVHLEKGDLPAALEASIACH 848

  Fly   885 NTHKHTPLQFELLSLLVRLGNGD-EQELTRFPGVTAESAQQHLAVVTATVSRIHGAANMNSALLL 948
            ..:|..|...::|..||..|..| .|:...|                  ||:..|...|...|..
Mouse   849 KKYKVLPRIHDVLCKLVEKGETDLIQKAMDF------------------VSQEQGEMTMLYDLFF 895

  Fly   949 ALAESGKETQLRRLIINPEFRINHELLVKNCEHLGQEGAVRTLLRLARGVRGVQRT-----IDEQ 1008
            |..::|...:.:::|..|..|.....|...|:.......|..|.:|      |:.|     .|..
Mouse   896 AFLQTGNYKEAKKIIETPGIRARPTRLQWFCDRCIASNQVEALEKL------VELTEKLFECDRD 954

  Fly  1009 KIYDLLLAQFCRSNDYEAALDLFERLEADDELKVSHEFLRNLVQLLQVNQVEIP 1062
            ::|..||..:..|:|::.|...:.::: ::.:......||.|.::|:.:..|:|
Mouse   955 QMYYNLLKLYKISSDWQRADAAWTKMQ-EENIIPRERTLRLLAEILKTSNQEVP 1007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrpprc2	NP_569913.1	PLN03218	<197..>292	CDD:215636	32/94 (34%)
		PPR repeat	201..227	CDD:276811	7/25 (28%)
		PPR repeat	233..262	CDD:276811	14/28 (50%)
		PPR repeat	268..292	CDD:276811	5/23 (22%)
Lrpprc	NP_082509.2	PPR 1	125..159		14/34 (41%)
		PPR repeat	128..155	CDD:276811	10/27 (37%)
		PPR_2	160..208	CDD:289786	13/53 (25%)
		PPR 2	160..194		11/39 (28%)
		PPR repeat	163..190	CDD:276811	9/32 (28%)
		PPR	191..223	CDD:295754	6/31 (19%)
		PPR_2	194..243	CDD:289786	15/48 (31%)
		PPR 3	195..229		8/33 (24%)
		PPR repeat	198..225	CDD:276811	7/26 (27%)
		PPR 4	230..264		18/33 (55%)
		PPR_3	231..264	CDD:290526	17/32 (53%)
		PPR repeat	231..260	CDD:276811	14/28 (50%)
		PPR 5	265..299		8/33 (24%)
		PPR repeat	266..295	CDD:276811	6/28 (21%)
		PPR 6	300..334		5/38 (13%)
		PPR 7	402..436		7/33 (21%)
		PPR 8	437..471		12/33 (36%)
		PPR 9	677..708		7/30 (23%)
		PPR 10	709..745		8/41 (20%)
		PPR repeat	713..739	CDD:276811	4/25 (16%)
		PPR 11	746..783		8/37 (22%)
		PPR repeat	747..776	CDD:276811	5/28 (18%)
		PPR 12	784..820		8/49 (16%)
		PPR repeat	785..809	CDD:276811	6/31 (19%)
		PPR 13	821..856		9/34 (26%)
		RNA-binding	931..1050		18/84 (21%)
		PPR 15	1030..1064
		PPR 16	1065..1101
		PPR repeat	1066..1097	CDD:276811
		PPR 17	1102..1136
		PPR repeat	1103..1127	CDD:276811
		PPR 18	1137..1175
		PPR 19	1176..1210
		PPR 20	1315..1349
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I8940
eggNOG	1	0.900	-	-		E1_KOG4318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.759104	Normalized mean entropy	S7417
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46669
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.820