DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrpprc2 and lrpprc

DIOPT Version :9

Sequence 1:	NP_569913.1	Gene:	Lrpprc2 / 31095	FlyBaseID:	FBgn0027794	Length:	1072	Species:	Drosophila melanogaster
Sequence 2:	NP_001136064.1	Gene:	lrpprc / 557195	ZFINID:	ZDB-GENE-030131-7887	Length:	1436	Species:	Danio rerio

Alignment Length:	1158	Identity:	253/1158 - (21%)
Similarity:	458/1158 - (39%)	Gaps:	223/1158 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ARLLRNVWLCRQRLGHLPGRSASSASLAFRYATKPAAPAVPFSLLQMRSLGT-----------GG 57
            |.|||:..|.:          .|||||.........|||.  ..|...::||           .|
Zfish     2 AALLRSARLLK----------TSSASLIQVIGNSKHAPAA--GRLYSGAIGTLRVGVCGRQTVPG 54

  Fly    58 VLSAVERRSRRPA---------------SSSEKPKASVAD----------AWTQLEAYYRQHDLI 97
            .|:|....|.|||               |...|.:||:|.          |.::|::..|:...:
Zfish    55 RLNANSLFSYRPALPCVSCRQYAVVPEQSGQVKDEASLAVRSKQAQQFDWALSKLDSSVRRTGRV 119

  Fly    98 NFEHCQRLLELLQESASPLGVGIEEVHFLLGSCVPELLPAQSSQERLQLFKGLWAQLIKLG-QPT 161
            .......:...:..:..|.|   .:...||.|| ..|||.....||.:|.|.:|.:|::|| ...
Zfish   120 TKTLLLHIFHDICRTGYPSG---NQALLLLRSC-GSLLPEVPLAERTELVKRIWDKLLELGVSYD 180

  Fly   162 LAHYHTKLQVLRQN--RLPLTDYRSLLAEIAVYHGAADSTLYGALLDVAGAAGNMRMATEILSEM 224
            ::||:..|:...||  |...||:   ||::...:...:...|..|:......||:..|:.||..|
Zfish   181 VSHYNALLKTYLQNEFRFSPTDF---LAKMEAANVQPNRVTYQRLIAAYCEEGNIEGASAILGFM 242

  Fly   225 RERSLALTEHNFHALLLGHARSGDLPGAESVLASMRAAGIQQGSSTQAIWFEALLENGQLAQAKE 289
            :.:.|.:||..|::|::||||:||:..:|.:|:.|::|||:.|..|.........|.|.:.:.|:
Zfish   243 KNKDLPITEAVFNSLVVGHARAGDITSSEGILSVMKSAGIEPGPDTYLSLLNMYAEKGDIDKIKQ 307

  Fly   290 LLQVEHGFTAPQLLQMLRGLLASKD---VDTDLIQLLVKELPREFLTGID--------------- 336
            .|.|                :.:.|   :|.||:| ||..|.|   ||.:
Zfish   308 TLDV----------------VENADFFLMDRDLMQ-LVSSLAR---TGHEQHVPEIVSRMRHERG 352

  Fly   337 -LPPAIRSLCIQLVHQGRTEVVIQLVGALPAPKFELQNQNVDEYGALLLQEFFRAQVPLDQTIQF 400
             :|.|| :||:.|:..|..:....::.:|.. ..:....:..::|...|:.........:..:.|
Zfish   353 YVPDAI-NLCLNLITHGHEKTAFSVLKSLTG-MLDTHTGDTPDFGNFFLRHCVNMDKSAEDIVGF 415

  Fly   401 AGQLVQRNQNVRALHLVAELALR-RQPSSALRCLEDLSAAGEELRPHYFWPLILHHYRREGESGM 464
            ...|.....:...|....:.||. ::.|.::..::.:.|....::||||.||..||::.:....:
Zfish   416 CKDLKDLGLHSTPLQFTLQCALEGKKTSLSIGLMKRMKAESLPIKPHYFLPLFAHHHKDKNIPAI 480

  Fly   465 LRLVSEMRRLRVECDEETLRHYLFPHLRQTLVQPLEAVKA-LESAGVKPSQTLCPVVSHLLQQH- 527
            :.::..|:.:.|..|.:....|:.|..     ..|:..|| |:.|||..:.....|....:|.:
Zfish   481 IEVLRGMQEMSVSPDVDAFSFYILPSF-----PSLDNAKASLKEAGVDVNTDGLIVAELRVQAYS 540

  Fly   528 -QMSEVLDLLD--RYPTRLDLATLLQPLSSLAVNARATKRF---EVFAKVIQALQQKA--LKRGE 584
             .::::|.|:.  ..|| :||:.....|.:      ..|||   |..||:.:.|.:.|  ...|.
Zfish   541 GNLAKLLSLMSSPALPT-IDLSVFRAGLIA------GFKRFQNVENMAKITELLYKDARFAADGH 598

  Fly   585 D-------FVGSLLLQMTGPQTRLRQDATSLRRFLHELRRLELQISPAASEALLSVVRHATDDVD 642
            |       |:.:|:..|:  :|.|:.:...:|.:...|:.:.:.||                 |:
Zfish   599 DASENVGYFLYNLIDSMS--ETELQSNEEKIREYFGLLKSMNINIS-----------------VN 644

  Fly   643 LIQDLAKTLQKMKNPQLALPADTVSLHGGFIKHPRDMS-----------IDELECHLVELESKQL 696
            :.:.:...|:....|:|...|.|:      :....||:           |..|...|.|.:::..
Zfish   645 IFRGIRNILESHHVPELVKEALTL------VDKTDDMTEVMMFRSSEGRISALVKTLAEQKAEGK 703

  Fly   697 NPRGVLRRLLQLSVRSGRLERAQQLLAKCQVLKVQESAGMMASIFDLHIKLRDLPRAQESLERLS 761
            .....|::|:.:.....:||:|..|.:|.:......:...:.::...|....:..:.:..:.|..
Zfish   704 PAHLTLKKLINVLSIEEKLEQALDLKSKYEDDMTPAAYATLINLCCRHDNAEEALKLKIEMARKD 768

  Fly   762 SMYPAFQIDEHKVIDYAALLVQGQQLEAAKQLLQRRAEQHKVVGGDYVMKNVWQLLT-NVGQLAA 825
            |   ...:|..|.|....:|.:..:||.|..:|:...|::.:     :..|:...|| .:..:|.
Zfish   769 S---EVALDAQKYIALVRVLSKHGKLEEALDILKEMKEKNIM-----IRDNLIGFLTFTMNSIAM 825

  Fly   826 SSHAGGESSKQLNQTREWLDFLRGLGYCQSQNALLGPVVREWLLKGNLDAAVAEFQRLANTHK-- 888
            ...|  ::.::|.:|      :..||..:..|.|..|:|..:|..|:...|   |..:...||
Zfish   826 KGDA--DAIRRLQET------IFTLGLAKPSNGLCSPLVTCYLESGDHAGA---FDAVMECHKQY 879

  Fly   889 -HTPLQFELLSLLVRLGNGDEQELTRFPGVTAESAQQHLAVVTATVSRIHGAANMNSALLLALAE 952
             ..|...:|:..||..|:          .:..:...:.|     |:.|  |...|...|..|..:
Zfish   880 NQLPKIHDLMCSLVEKGD----------ALLLQKVMEFL-----TLER--GEMMMLYDLFFAFLQ 927

  Fly   953 SGKETQLRRLIINPEFRINHELL---VKNCEHLGQEGAVRTLLRLARGVRGVQRTI-----DEQK 1009
            :|:..:.|::|..|..|.....|   .:.|....|...:..|         |..|:     |..:
Zfish   928 TGRNREARKIIETPGLRARSNRLQWFAEKCIAAQQMEPLENL---------VDMTVKLFECDRDE 983

  Fly  1010 IYDLLLAQFCRSNDYEAALDLFERLEADDELKVSHEFLRNLVQLLQVNQVEIP 1062
            :|..|......:||:..|..::.::: ::.|......||.|.::|:.|..|:|
Zfish   984 MYHYLFRLCKETNDWRKAEAIWMKMQ-EENLAPRERTLRLLAEILKSNNQEVP 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrpprc2	NP_569913.1	PLN03218	<197..>292	CDD:215636	30/94 (32%)
		PPR repeat	201..227	CDD:276811	8/25 (32%)
		PPR repeat	233..262	CDD:276811	12/28 (43%)
		PPR repeat	268..292	CDD:276811	4/23 (17%)
lrpprc	NP_001136064.1	PPR repeat	183..210	CDD:276811	10/29 (34%)
		PPR	211..243	CDD:295754	7/31 (23%)
		PPR_2	214..263	CDD:289786	15/48 (31%)
		PPR repeat	218..245	CDD:276811	8/26 (31%)
		PPR repeat	251..280	CDD:276811	12/28 (43%)
		PPR repeat	286..310	CDD:276811	4/23 (17%)
		PPR repeat	708..735	CDD:276811	7/26 (27%)
		PPR repeat	738..769	CDD:276811	2/30 (7%)
		PPR repeat	775..804	CDD:276811	7/28 (25%)
		PPR	778..806	CDD:279828	7/27 (26%)
		PPR repeat	812..842	CDD:276811	6/37 (16%)
		PPR repeat	1080..1102	CDD:276811
		PPR repeat	1108..1135	CDD:276811
		PPR repeat	1145..1173	CDD:276811
		PPR repeat	1180..1209	CDD:276811
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D64969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46669
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920