DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG14785 and KLHL1

DIOPT Version :10

Sequence 1:NP_569912.2 Gene:CG14785 / 31094 FlyBaseID:FBgn0027795 Length:470 Species:Drosophila melanogaster
Sequence 2:NP_065917.1 Gene:KLHL1 / 57626 HGNCID:6352 Length:748 Species:Homo sapiens


Alignment Length:414 Identity:87/414 - (21%)
Similarity:154/414 - (37%) Gaps:107/414 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 KKQDRR------PKPEPEKLESGAQGDAGSASSTSAHAVK--LLPI-----EGDPAKLKALTSRQ 109
            |.|:|.      .||.    .|.:...:.|:||:|.:.:.  |||:     :|.|.:     ..|
Human    58 KSQERSGVSTFWKKPS----SSSSSSSSPSSSSSSFNPLNGTLLPVATRLQQGAPGQ-----GTQ 113

  Fly   110 QIASLLNHL---------GDGAEGDGEAKQIVMEL---------------------LGSGVQPHS 144
            |.|..|.::         |....|..|...::.||                     .|..:.|.|
Human   114 QPARTLFYVESLEEEVVPGMDFPGPHEKGLVLQELKVEPDNSSQATGEGCGHRLSSTGHSMTPQS 178

  Fly   145 AIERVSE----QLLH-----------VLREQTLMEAGIFVGNERYRFFKGVLQNYAKIYAARKFI 194
            .::..|.    |.:|           .|::|.|.:..:.|||.:....:.||.:.:..:||....
Human   179 DLDSSSSEEFYQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTS 243

  Fly   195 DKLP------KLDQLGPDAGAERELFA--------------RVVAEEVLQIPQLLRQLRSSLSKM 239
            |...      |::.:.|:|..:...||              .:.|..:||:||::......|.|:
Human   244 DVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKL 308

  Fly   240 EFFNEDTAFKAYLEVRYHPQARILCELMLTRISRV---FLCIVGSPFFLYFTEHELTHILRNCYL 301
            ...:.....:|:.:      |:...|||....|..   .:.::.:..||.....||..:|.:..:
Human   309 LHPSNCLGIRAFAD------AQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDV 367

  Fly   302 SVNSEIEIFLSVVLWLEHNWLERGDCAERILAEVHFALMPTWYLCTLDRSNRCNHFARVIHSPGV 366
            :|..|..||.::::|::::...|.:....:||.:...|:|...|..|:     || |...:....
Human   368 NVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILADLE-----NH-ALFKNDLEC 426

  Fly   367 QRLIAAG-----LEDAITLKSKPR 385
            |:||...     |.:..||...||
Human   427 QKLILEAMKYHLLPERRTLMQSPR 450

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG14785NP_569912.2 BACK 256..345 CDD:197943 20/91 (22%)
DUF4734 359..450 CDD:434992 8/32 (25%)
KLHL1NP_065917.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 22..93 10/38 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 151..182 3/30 (10%)
PHA03098 206..728 CDD:222983 57/257 (22%)
Kelch 1 460..506
KELCH repeat 496..539 CDD:276965
Kelch 2 507..553
KELCH repeat 543..587 CDD:276965
Kelch 3 555..600
KELCH repeat 590..633 CDD:276965
Kelch 4 601..647
KELCH repeat 637..687 CDD:276965
Kelch 5 649..700
KELCH repeat 690..734 CDD:276965
Kelch 6 701..747
Blue background indicates that the domain is not in the aligned region.

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