Protein Alignment CG14785 and KLHL18

DIOPT Version :10

• Sequence 1: NP_569912.2
• Gene: CG14785 / 31094
• FlyBaseID: FBgn0027795
• Length: 470
• Species: Drosophila melanogaster
• Sequence 2: XP_005265058.2
• Gene: KLHL18 / 23276
• HGNCID: 29120
• Length: 584
• Species: Homo sapiens
• Alignment Length: 266
• Identity: 53/266 - (19%)
• Similarity: 103/266 - (38%)
• Gaps: 41/266 - (15%)

  Fly   120 DGAEGDGEAKQIVMELLGSGVQPHSAIERVSEQ----LLHVLREQTLMEAGIFVGNERYRFFKGV 180
            ||||   |.:.:|          |.::..:..:    :..:.|:..|.:..:.:|:.::...:.|
Human     4 DGAE---ELEDLV----------HFSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIV 55

  Fly   181 LQNYAKIYAARKFIDKLP-KLDQL---GPDAGAERELFARVVAEEVLQIPQLLRQLRSSLSKMEF 241
            |......:.|....|.:. |.|::   |.|..|...|........:....|.::.|....|.::.
Human    56 LAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQL 120

  Fly   242 FNEDTAFKAYLEVRYHPQ----ARILCELML---------TRISRVFLCIVGSPFFLYFTEHELT 293
            .:...|...:|..|.||:    .|...|.|:         :.|.:.|:.:..|..||.....::.
Human   121 QSIKDACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVL 185

  Fly   294 HILRNCYLSVNSEIEIFLSVVLWLEHNWLERGDCAERILAEVHFALMPTWYLCTLDRSN-----R 353
            .::....|:|.||.::|.:.:.|:.::..:||.....:|:.:...|....:|.  ||..     |
Human   186 ELVSRDELNVKSEEQVFEAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLS--DRVQQDDLVR 248

  Fly   354 CNHFAR 359
            |.|..|
Human   249 CCHKCR 254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14785	NP_569912.2	BACK	256..345	CDD:197943	20/101 (20%)
		DUF4734	359..450	CDD:434992	1/1 (100%)
KLHL18	XP_005265058.2	BTB_POZ_KLHL18	19..134	CDD:349556	18/114 (16%)
		PHA03098	34..562	CDD:222983	45/223 (20%)
		BACK_KLHL18	135..241	CDD:350532	22/107 (21%)
		KELCH repeat	282..327	CDD:276965
		KELCH repeat	331..374	CDD:276965
		KELCH repeat	378..427	CDD:276965
		KELCH repeat	430..474	CDD:276965
		KELCH repeat	477..521	CDD:276965
		KELCH repeat	524..567	CDD:276965