Protein Alignment Rilpl and Rilp

DIOPT Version :10

• Sequence 1: NP_001259133.1
• Gene: Rilpl / 31090
• FlyBaseID: FBgn0024985
• Length: 486
• Species: Drosophila melanogaster
• Sequence 2: NP_001025109.1
• Gene: Rilp / 280408
• MGIID: 2144271
• Length: 369
• Species: Mus musculus
• Alignment Length: 419
• Identity: 110/419 - (26%)
• Similarity: 164/419 - (39%)
• Gaps: 135/419 - (32%)

  Fly    25 VYDLASDIGKEYERIMDRFGTDAVSGLMPKIINTLELLEALATKNERENATIQELRDKVAQLESE 89
            ||.||..:|.|.:.:..|||.||.:||:|.::..||||         |.|.:....|.: |:.::
Mouse    27 VYHLAGALGTELQGLARRFGPDAAAGLVPLVVRALELL---------EKAAVGPAPDSL-QVSAQ 81

  Fly    90 KLEKAEFRRRFDKELELIEEQWRSETNELVDLVSSLQDENKRLVKQTQDLQSSSAQSSGLGASLT 154
            :.| .|.||                          |::||:||   .|:|.|...:...|
Mouse    82 QAE-VELRR--------------------------LREENQRL---RQELGSGPQEERAL----- 111

  Fly   155 ESIISMTNHELHSALSDTQVLQRLKEQIYKQRDELKHRERELQDKYSELEHLNIQAERLKASERD 219
                                |::|||...:|||||:...|:||.:..|.|.|..|.:||.....:
Mouse   112 --------------------LRQLKEVTDRQRDELRAHNRDLQRRSQETEALQEQLQRLLLINSE 156

  Fly   220 TRRRHKLMQAQVKTLCEERADFLAQLQDQSREI-----NQLRKRLGLAEKENEDLVASYD--DGQ 277
            .|.:...:|.|::.         ||.:::.|:|     :||.|...|    ..|...|.|  |.|
Mouse   157 LRHKLAAVQTQLRA---------AQDRERERQIAQDGSSQLAKEQSL----EPDAATSDDPVDTQ 208

  Fly   278 NDP-NRPR-----YTTRELKELISERDELLTTIDTLNEQLA----ELKPPSQAKG---------- 322
            ..| |.|.     ::..|||:::.||:||...:..|.|:||    ||....:..|
Mouse   209 KQPGNLPEAVQCGFSREELKQILQERNELKANVFLLKEELAYFQRELLTDHRVPGLLLEAMKVAV 273

  Fly   323 KRQRH--------FSSSDDSDEDDDGH--VADNDDDD-----------------DEEEAAAEANE 360
            |:||.        .....:|.||:||.  :..||.:|                 ..|..|.|| |
Mouse   274 KKQRRKIKAKMLGTPEEAESSEDEDGSWLLLSNDKEDVPLVPESRIQNFFGLWYRGETEAPEA-E 337

  Fly   361 LEPPAAGETPPGHDAPVQGPLPYEPDDAP 389
            ...||:.....|.:.|.|..|  :|.::|
Mouse   338 TSNPASSSLQKGEETPQQPHL--QPVNSP 364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rilpl	NP_001259133.1	Jnk-SapK_ap_N	25..187	CDD:462875	40/161 (25%)
		SMC_prok_B	<64..>315	CDD:274008	66/267 (25%)
Rilp	NP_001025109.1	RILP-like	11..107	CDD:271220	34/119 (29%)
		Smc	<74..>260	CDD:440809	65/254 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	173..219		14/49 (29%)
		RILP	223..287	CDD:463282	17/63 (27%)
		Necessary for interaction with RAB7A and RAB34 and lysosomal distribution and morphology. /evidence=ECO:0000250	251..312		14/60 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	332..369		12/36 (33%)