Protein Alignment Rilpl and DZIP1L

DIOPT Version :10

• Sequence 1: NP_001259133.1
• Gene: Rilpl / 31090
• FlyBaseID: FBgn0024985
• Length: 486
• Species: Drosophila melanogaster
• Sequence 2: XP_011510820.1
• Gene: DZIP1L / 199221
• HGNCID: 26551
• Length: 806
• Species: Homo sapiens
• Alignment Length: 524
• Identity: 113/524 - (21%)
• Similarity: 179/524 - (34%)
• Gaps: 166/524 - (31%)

  Fly    60 ELLEALATKNERENATIQELRDKVAQLESEKLE-----KAEFRRRFDKELELIEEQWRSETNELV 119
            |:||.|..|.:.....::..|:...|.:.::.|     :.|.::.|||   ..|::|.....|:.
Human   235 EVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEFDK---WKEQEWTKLYGEID 296

  Fly   120 DLVSSLQDENKRLVKQT-------QDLQSSSAQSSGLGASLTESIISMTNHELHSALSDTQVLQR 177
            .|.....||.|.:.||.       :.|||.|...|.||        |:.:.|....|...:.||.
Human   297 KLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLG--------SLRDEESEEWLRQARELQA 353

  Fly   178 LKEQIYKQRDELKHRERELQDKY-SELEHLNIQAERLKAS-ERDTRRRHKLMQAQVKTLCEERAD 240
            |:|:...|:.|.|.:.:||.::: :|.:.|..:.:||:|| .:|.::.....|.|:.||
Human   354 LREKTEIQKTEWKRKVKELHEEHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQISTL------ 412

  Fly   241 FLAQLQDQSREIN---------QLRKRLGL------AEKENEDLVASYDDGQNDPNRPRYTTREL 290
             .||||:|:|.|.         .|||..|:      .:.|.:......:|.|::.::.....|..
Human   413 -RAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRN 476

  Fly   291 KELISERDELLTTIDTLNEQLAELKPPSQAKG------------------KRQRHFS-------- 329
            ..|:.....:|.  |||.|:|..:.....|||                  ::.|.||
Human   477 PTLLKHFRPILE--DTLEEKLESMGIRKDAKGISIQTLRHLESLLRVQREQKARKFSEFLSLRGK 539

  Fly   330 -----SSDDSDEDDDGHVADNDDDDDE----------EEAAAEANELE---PPAAGETPP----- 371
                 :|...:..::|.|....|....          .||..:...|:   |....|.||
Human   540 LVKEVTSRAKERQENGAVVSQPDGQPSVKSQQSTLVTREAQPKTRTLQVALPSTPAEPPPPTRQS 604

  Fly   372 --GHDA---------------------PVQGP--------------------------------L 381
              .|.:                     |..||                                :
Human   605 HGSHGSSLTQVSAPAPRPGLHGPSSTPPSSGPGMSTPPFSSEEDSEGDRVQRVSLQPPKVPSRMV 669

  Fly   382 PYEPDDAPWK--KSSESGIRKFFRKLFSDPSDGSNTFPKRSLATLSKM--ALSATP-GSVSASAA 441
            |...||..|.  ::||...:        .|..||.|..:..:..|.|.  |.:..| |.||....
Human   670 PRPKDDWDWSDTETSEENAQ--------PPGQGSGTLVQSMVKNLEKQLEAPAKKPAGGVSLFFM 726

  Fly   442 ANLG 445
            .|.|
Human   727 PNAG 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rilpl	NP_001259133.1	Jnk-SapK_ap_N	25..187	CDD:462875	36/138 (26%)
		SMC_prok_B	<64..>315	CDD:274008	70/279 (25%)
DZIP1L	XP_011510820.1	Dzip-like_N	52..172	CDD:433498
		PTZ00121	<149..496	CDD:173412	72/280 (26%)