DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ssx and Syncrip

DIOPT Version :9

Sequence 1:	NP_569908.1	Gene:	ssx / 31086	FlyBaseID:	FBgn0024987	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_062640.2	Gene:	Syncrip / 56403	MGIID:	1891690	Length:	623	Species:	Mus musculus

Alignment Length:	448	Identity:	85/448 - (18%)
Similarity:	156/448 - (34%)	Gaps:	154/448 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 AGQQQQMQQVDRTSATNLIINYLPQDMTDRELYNLFSGCGPINTCKIMRDFKTGYSFGYGFVDYK 142
            :|||..:       .|.:.:..:|:|:.:.||..||...|||...::|.|..||.:.||.||.:.
Mouse   154 SGQQPSV-------GTEIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFC 211

  Fly   143 TESDSEDAIQKLNGFYVR------------NKRLKVS---------------------------Y 168
            |:..:::|::..|...:|            |.||.|.                           |
Mouse   212 TKEAAQEAVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILY 276

  Fly   169 ARPGGQS------------------------------------------IKDTN---------LY 182
            .:|..:.                                          |:|.:         |:
Mouse   277 HQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWADPIEDPDPEVMAKVKVLF 341

  Fly   183 VINLSRNINDDMLDRIFSPYGLIVQRNILRDKLTGRPRGVAFVRYNKREEAQEAIKALNNTVPEG 247
            |.||:..:.:::|::.||.:|.:.:...|:|        .||:.:::|:.|.:|::.:|....||
Mouse   342 VRNLANTVTEEILEKSFSQFGKLERVKKLKD--------YAFIHFDERDGAVKAMEEMNGKDLEG 398

  Fly   248 GS-QPIWVRLAEEHGKAKAAQFMAQIGGGNGGGGG----GPPHMGP----------GGPMHPPHH 297
            .: :.::.:..::..|.:.||..|   ..|.....    |||||.|          ||..:||.:
Mouse   399 ENIEIVFAKPPDQKRKERKAQRQA---AKNQMYDDYYYYGPPHMPPPTRGRGRGGRGGYGYPPDY 460

  Fly   298 HNNHHHNNHHNPHMPPHHHQPQHPHQHPQHHPQLHHM----------QHHHPNNHNNNHPNNHHH 352
            :....:.:::.    ..:|..:..::.|.:..:...:          :...|:......|
Mouse   461 YGYEDYYDYYG----YDYHNYRGGYEDPYYGYEDFQVGARGRGGRGARGAAPSRGRGAAP----- 516

  Fly   353 NNNNNNHHNMGGPHPHHMQQMHPMGMNMGM-GVNMGMGMGMGMPIHGGGGGGGGGGGG 409
            ......:...|||           |...|: |...|.....|..:.|..||.||..||
Mouse   517 PRGRAGYSQRGGP-----------GSARGVRGARGGAQQQRGRGVRGARGGRGGNVGG 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ssx	NP_569908.1	RRM_SF	93..173	CDD:302621	28/118 (24%)
ssx	NP_569908.1	RRM_SF	179..257	CDD:302621	18/87 (21%)
Syncrip	NP_062640.2	hnRNP_Q_AcD	34..103	CDD:375786
		hnRNP-R-Q	103..615	CDD:273732	85/448 (19%)
		Interaction with APOBEC1. /evidence=ECO:0000250	400..561		32/183 (17%)
		8 X 3 AA repeats of R-G-G	448..559		19/130 (15%)
		3 X 4 AA repeats of Y-Y-G-Y	460..488		2/31 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..623		17/83 (20%)
		Interaction with SMN. /evidence=ECO:0000250	518..549		8/41 (20%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	564..578		85/448 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910