DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ssx and HNRNPA2B1

DIOPT Version :9

Sequence 1:	NP_569908.1	Gene:	ssx / 31086	FlyBaseID:	FBgn0024987	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_112533.1	Gene:	HNRNPA2B1 / 3181	HGNCID:	5033	Length:	353	Species:	Homo sapiens

Alignment Length:	386	Identity:	88/386 - (22%)
Similarity:	141/386 - (36%)	Gaps:	103/386 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 LIINYLPQDMTDRELYNLFSGCGPINTCKIMRDFKTGYSFGYGFVDYKTESDSEDAI----QKLN 155
            |.|..|..:.|:..|.|.:...|.:..|.:|||..:..|.|:|||.:.:.::.:.|:    ..::
Human    23 LFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSID 87

  Fly   156 GFYVRNKR--LKVSYARPGGQ-SIKDTNLYVINLSRNINDDMLDRIFSPYGLIVQRNILRDKLTG 217
            |..|..||  .:....:||.. ::|  .|:|..:..:..:..|...|..||.|....|:.|:.:|
Human    88 GRVVEPKRAVAREESGKPGAHVTVK--KLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSG 150

  Fly   218 RPRGVAFVRYNKREEAQEAIKALNNTVPEGGSQPIWVRLAEEHGKAKAAQFMAQIGGGNGG---- 278
            :.||..||.::..:...:.:....:|:....::   ||.|....:.:..|......|||.|
Human   151 KKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAE---VRKALSRQEMQEVQSSRSGRGGNFGFGDS 212

  Fly   279 -GGGGPPHMGPGGPMHPPHHHNNHHHNNHHNPHMPPHHHQPQHPHQHPQHHPQLHHMQHHHPNNH 342
             ||||  :.|||                                                 |.::
Human   213 RGGGG--NFGPG-------------------------------------------------PGSN 226

  Fly   343 NNNHPNNHHHNNNNNNHHN--MGGPHPHHMQQMHPMGMNMGMGVNMGMGMGMGMPIHGGGGGGGG 405
            .....:.:.......:.:|  .|||...:      .|.:.|.|...| |.|.|.|.:|..|||.|
Human   227 FRGGSDGYGSGRGFGDGYNGYGGGPGGGN------FGGSPGYGGGRG-GYGGGGPGYGNQGGGYG 284

  Fly   406 GG----GGG--GGGNFHHMAHRGEVFMLPLPICSRFPSQPHPVGNGICHSPNKNSRFRLSR 460
            ||    |||  |.||::...:              :..||...|      |.|:..|..||
Human   285 GGYDNYGGGNYGSGNYNDFGN--------------YNQQPSNYG------PMKSGNFGGSR 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ssx	NP_569908.1	RRM_SF	93..173	CDD:302621	22/83 (27%)
ssx	NP_569908.1	RRM_SF	179..257	CDD:302621	17/77 (22%)
HNRNPA2B1	NP_112533.1	Nuclear localization signal. /evidence=ECO:0000255	9..15
		RRM1_hnRNPA2B1	19..99	CDD:410155	21/75 (28%)
		RRM2_hnRNPA2B1	112..191	CDD:409995	19/83 (23%)
		Disordered. /evidence=ECO:0000269\|PubMed:26544936	193..353		46/211 (22%)
		HnRNPA1	302..326	CDD:402981	8/44 (18%)
		Nuclear targeting sequence. /evidence=ECO:0000250	308..347		8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1202220at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010