DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ssx and HNRNPA1

DIOPT Version :9

Sequence 1:	NP_569908.1	Gene:	ssx / 31086	FlyBaseID:	FBgn0024987	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_112420.1	Gene:	HNRNPA1 / 3178	HGNCID:	5031	Length:	372	Species:	Homo sapiens

Alignment Length:	350	Identity:	86/350 - (24%)
Similarity:	127/350 - (36%)	Gaps:	88/350 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 LIINYLPQDMTDRELYNLFSGCGPINTCKIMRDFKTGYSFGYGFVDYKTESDSEDAI----QKLN 155
            |.|..|..:.||..|.:.|...|.:..|.:|||..|..|.|:|||.|.|..:.:.|:    .|::
Human    16 LFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKVD 80

  Fly   156 GFYVRNKRL--KVSYARPGGQ-SIKDTNLYVINLSRNINDDMLDRIFSPYGLIVQRNILRDKLTG 217
            |..|..||.  :....|||.. ::|  .::|..:..:..:..|...|..||.|....|:.|:.:|
Human    81 GRVVEPKRAVSREDSQRPGAHLTVK--KIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSG 143

  Fly   218 RPRGVAFVRYNKREEAQEAI---------------KALNNTVPEGGSQPIWVRLAEEHGKAKAAQ 267
            :.||.|||.::..:...:.:               |||:.......|       :.:.|::.:..
Human   144 KKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASAS-------SSQRGRSGSGN 201

  Fly   268 FMAQIGGGNGGGGGGPPHMGPGGPMHPPHHHNNHHHNNHHNPHMPPHHHQPQHPHQHPQHHPQLH 332
            |    |||.|||.||..:.|.||..........
Human   202 F----GGGRGGGFGGNDNFGRGGNFSGRGGFGG-------------------------------- 230

  Fly   333 HMQHHHPNNHNNNHPNNHHHNNNNNNHHNMGGPHPHHMQQMHPMGMNMGMGVNMGMGMGMGMPIH 397
                   :.....:..:....|...|....||..|.:      .|.:.|.| :.|.|.|.....:
Human   231 -------SRGGGGYGGSGDGYNGFGNDGGYGGGGPGY------SGGSRGYG-SGGQGYGNQGSGY 281

  Fly   398 GGGG-------GGGGGGGGGGGGNF 415
            ||.|       |||||.|||.|.||
Human   282 GGSGSYDSYNNGGGGGFGGGSGSNF 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ssx	NP_569908.1	RRM_SF	93..173	CDD:302621	28/83 (34%)
ssx	NP_569908.1	RRM_SF	179..257	CDD:302621	18/92 (20%)
HNRNPA1	NP_112420.1	Globular A domain	4..94		26/77 (34%)
		RRM1_hnRNPA1	12..92	CDD:410154	26/75 (35%)
		Globular B domain	95..185		21/91 (23%)
		RRM2_hnRNPA3	105..184	CDD:409996	18/80 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..216		11/44 (25%)
		RNA-binding RGG-box	218..240		2/60 (3%)
		HnRNPA1	307..344	CDD:402981	85/349 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..372
		Nuclear targeting sequence (M9)	320..357
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1202220at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920