DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ssx and HNRNPA3

DIOPT Version :9

Sequence 1:	NP_569908.1	Gene:	ssx / 31086	FlyBaseID:	FBgn0024987	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_001317178.1	Gene:	HNRNPA3 / 220988	HGNCID:	24941	Length:	378	Species:	Homo sapiens

Alignment Length:	396	Identity:	91/396 - (22%)
Similarity:	146/396 - (36%)	Gaps:	106/396 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 GDGQEHSGDEEQHHSQDNEGNDNSAGQQQQMQQVDRTSATNLIINYLPQDMTDRELYNLFSGCGP 118
            |..|..||...:...:  ||:|....:|.:          .|.|..|..:.||..|...|...|.
Human     8 GRPQPDSGRRRRRRGE--EGHDPKEPEQLR----------KLFIGGLSFETTDDSLREHFEKWGT 60

  Fly   119 INTCKIMRDFKTGYSFGYGFVDYKTESDSEDAI----QKLNGFYVRNKRL--KVSYARPGGQ-SI 176
            :..|.:|||.:|..|.|:|||.|....:.:.|:    .|::|..|..||.  :....:||.. ::
Human    61 LTDCVVMRDPQTKRSRGFGFVTYSCVEEVDAAMCARPHKVDGRVVEPKRAVSREDSVKPGAHLTV 125

  Fly   177 KDTNLYVINLSRNINDDMLDRIFSPYGLIVQRNILRDKLTGRPRGVAFVRYNKREEAQEAIKALN 241
            |  .::|..:..:..:..|...|..||.|....::.|:.:|:.||.|||.::..:...:.:....
Human   126 K--KIFVGGIKEDTEEYNLRDYFEKYGKIETIEVMEDRQSGKKRGFAFVTFDDHDTVDKIVVQKY 188

  Fly   242 NTVPEGGSQPIWVRLAEEHGKAKAAQ---------FMAQIGGGNGGGGGGPPHMGPGGPMHPPHH 297
            :|: .|.:..:...|:::..::..:|         ||.:  |||.|||||  :.|.||
Human   189 HTI-NGHNCEVKKALSKQEMQSAGSQRGRGGGSGNFMGR--GGNFGGGGG--NFGRGG------- 241

  Fly   298 HNNHHHNNHHNPHMPPHHHQPQHPHQHPQHHPQLHHMQHHHPNNHNNNHPNNHHHNNNNNNHHNM 362
              |......:.                                  .....:...:...:..::..
Human   242 --NFGGRGGYG----------------------------------GGGGGSRGSYGGGDGGYNGF 270

  Fly   363 GGPHPHHMQQMHPMGMNMGMGVNMGM--GMGMGMPIHGGGGGGGGGGGG---------------G 410
            ||.           |.|.|.|.....  |.|.|.|.:|..|||.|||||               |
Human   271 GGD-----------GGNYGGGPGYSSRGGYGGGGPGYGNQGGGYGGGGGYDGYNEGGNFGGGNYG 324

  Fly   411 GGGNFH 416
            ||||::
Human   325 GGGNYN 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ssx	NP_569908.1	RRM_SF	93..173	CDD:302621	26/85 (31%)
ssx	NP_569908.1	RRM_SF	179..257	CDD:302621	15/77 (19%)
HNRNPA3	NP_001317178.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		8/28 (29%)
		RRM1_hnRNPA_like	36..113	CDD:409992	25/76 (33%)
		RRM2_hnRNPA3	126..205	CDD:409996	17/81 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..225		2/20 (10%)
		HnRNPA1	331..>347	CDD:402981	91/396 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	336..378
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1202220at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920