DRSC/TRiP Functional Genomics Resources

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Protein Alignment png and NEK3

DIOPT Version :10

Sequence 1:NP_477492.1 Gene:png / 31084 FlyBaseID:FBgn0000826 Length:291 Species:Drosophila melanogaster
Sequence 2:NP_001411193.1 Gene:NEK3 / 4752 HGNCID:7746 Length:512 Species:Homo sapiens


Alignment Length:235 Identity:79/235 - (33%)
Similarity:129/235 - (54%) Gaps:24/235 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 VRVLGQGTFGRVFLCHQNEVRGQPERKVCVKRIIVRNPK--TELGLIKEEVYIISQLRHPHIVEF 73
            :|::|:|:|||..|. |:|...|   ...:|.|  |.||  :.....::|..::::::||:||.|
Human     7 LRMIGEGSFGRALLV-QHESSNQ---MFAMKEI--RLPKSFSNTQNSRKEAVLLAKMKHPNIVAF 65

  Fly    74 LRSFSH------AGTVNIVMEYVPNGTLRDVIQQLPSGTGGV-NQERLMGYFRDMVVGLEYLHIR 131
            ..||..      .|.:.|||||...|   |::|::....|.: .::.::.:|..|.:|:.::|.:
Human    66 KESFEELISVLAEGHLYIVMEYCDGG---DLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKK 127

  Fly   132 CVIHRDIKPENMLLDANDRVKIADFGIANVHA-PSTQLQAGMGTPMYMAPEAMSSQGKVDFKSDV 195
            .|:|||||.:|:.|..|.:||:.|||.|.:.: |.......:|||.|:.||...:. ..:.|||:
Human   128 RVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENL-PYNNKSDI 191

  Fly   196 WSLGLVLYELCLGRSPFAAFLDKNATPALLHTVVQALVRP 235
            ||||.:|||||..:.||.|    |:...|:..|.|..:.|
Human   192 WSLGCILYELCTLKHPFQA----NSWKNLILKVCQGCISP 227

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pngNP_477492.1 S_TKc 11..271 CDD:214567 79/235 (34%)
NEK3NP_001411193.1 STKc_Nek3 3..263 CDD:173759 79/235 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 308..331
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 447..496
Blue background indicates that the domain is not in the aligned region.

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