DRSC/TRiP Functional Genomics Resources

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Protein Alignment png and Nek3

DIOPT Version :10

Sequence 1:NP_477492.1 Gene:png / 31084 FlyBaseID:FBgn0000826 Length:291 Species:Drosophila melanogaster
Sequence 2:NP_001156419.1 Gene:Nek3 / 23954 MGIID:1344371 Length:511 Species:Mus musculus


Alignment Length:250 Identity:83/250 - (33%)
Similarity:134/250 - (53%) Gaps:34/250 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 VRVLGQGTFGRVFLCHQ---NEVRGQPERKVCVKRIIVRNPKTELGLIKEEVYIISQLRHPHIVE 72
            :||:|||:|||..|..|   |:.....|         :|..|::....::|..::::::||:||.
Mouse     7 LRVIGQGSFGRALLVLQESSNQTFAMKE---------IRLLKSDTQTSRKEAVLLAKMKHPNIVA 62

  Fly    73 FLRSFSHAGTVNIVMEYVPNGTLRDVIQQLPSGTGGV-NQERLMGYFRDMVVGLEYLHIRCVIHR 136
            |..||...|.:.|||||...|   |::|::....|.: .::.::.:|..:.:|:.::|.|.|:||
Mouse    63 FKESFEAEGYLYIVMEYCDGG---DLMQRIKQQKGKLFPEDTILNWFIQICLGVNHIHKRRVLHR 124

  Fly   137 DIKPENMLLDANDRVKIADFGIAN-VHAPSTQLQAGMGTPMYMAPEAMSSQGKVDFKSDVWSLGL 200
            |||.:|:.|..|.:||:.|||.|. :.:|.......:|||.|:.||...:. ..:.|||:||||.
Mouse   125 DIKSKNVFLTHNGKVKLGDFGSARLLSSPMAFACTYVGTPYYVPPEIWENL-PYNNKSDIWSLGC 188

  Fly   201 VLYELCLGRSPFAAFLDKN-----------ATPALLHTVVQALVRPRLDCQLIRR 244
            :|||||..:.||.|...||           ..|||....:|.||:     |:::|
Mouse   189 ILYELCALKHPFQANSWKNLILKICQGPIHPLPALYSCKLQGLVK-----QMLKR 238

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pngNP_477492.1 S_TKc 11..271 CDD:214567 82/249 (33%)
Nek3NP_001156419.1 Interaction with VAV2. /evidence=ECO:0000250 1..282 82/249 (33%)
Protein Kinases, catalytic domain 3..255 CDD:473864 82/249 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 299..370
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 443..511
Blue background indicates that the domain is not in the aligned region.

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