DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment png and Nek2

DIOPT Version :10

Sequence 1:NP_477492.1 Gene:png / 31084 FlyBaseID:FBgn0000826 Length:291 Species:Drosophila melanogaster
Sequence 2:NP_035022.2 Gene:Nek2 / 18005 MGIID:109359 Length:443 Species:Mus musculus


Alignment Length:215 Identity:74/215 - (34%)
Similarity:115/215 - (53%) Gaps:16/215 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 LGQGTFGRVFLCHQNEVRGQPERKVCVKRIIVRNPKTEL--GLIKEEVYIISQLRHPHIVEFL-R 75
            :|.|::||   |  .::|.:.:.|:.|.:.:.....||:  .::..||.::.:|:||:||.:. |
Mouse    14 IGTGSYGR---C--QKIRRKSDGKILVWKELDYGSMTEVEKQMLVSEVNLLRELKHPNIVSYYDR 73

  Fly    76 SFSHAG-TVNIVMEYVPNGTLRDVIQQLPSGTGGVNQERLMGYFRDMVVGLEYLHIR-----CVI 134
            ...... |:.|||||...|.|..||.:.......:.:|.::.....:.:.|:..|.|     .|:
Mouse    74 IIDRTNTTLYIVMEYCEGGDLASVISKGTKDRQYLEEEFVLRVMTQLTLALKECHRRSDGGHTVL 138

  Fly   135 HRDIKPENMLLDANDRVKIADFGIANVHAPSTQL-QAGMGTPMYMAPEAMSSQGKVDFKSDVWSL 198
            |||:||.|:.||:...||:.|||:|.:....|.. :..:|||.||:||.||.. ..:.|||:|||
Mouse   139 HRDLKPANVFLDSKHNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMSCL-SYNEKSDIWSL 202

  Fly   199 GLVLYELCLGRSPFAAFLDK 218
            |.:|||||....||.||..|
Mouse   203 GCLLYELCALMPPFTAFNQK 222

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pngNP_477492.1 S_TKc 11..271 CDD:214567 74/215 (34%)
Nek2NP_035022.2 STKc_Nek2 7..271 CDD:270857 74/215 (34%)
Interaction with PCNT. /evidence=ECO:0000250 264..443
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 282..303
Interaction with CEP85. /evidence=ECO:0000250|UniProtKB:P51955 301..443
Leucine-zipper 306..334
Necessary for interaction with MAD1L1. /evidence=ECO:0000250 329..443
Required for microtubule binding and for localization to the centrosomes. /evidence=ECO:0000250 333..370
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 383..402
Interaction with SAV1 and STK3/MST2. /evidence=ECO:0000250 402..437
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.