DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11417 and ESF1

DIOPT Version :9

Sequence 1:	NP_569906.1	Gene:	CG11417 / 31083	FlyBaseID:	FBgn0024364	Length:	771	Species:	Drosophila melanogaster
Sequence 2:	NP_010653.1	Gene:	ESF1 / 851969	SGDID:	S000002773	Length:	628	Species:	Saccharomyces cerevisiae

Alignment Length:	764	Identity:	237/764 - (31%)
Similarity:	359/764 - (46%)	Gaps:	180/764 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 AGANDSENGIWQDSRFQHLLTDPRFRGVPKVQRKVKIDKRFQGMFTDDKFKVKYTVDKYGRPV-- 94
            ||.|..:.|:  |:||..:.:||:|:.......|:|:|.||.....:.:.|.|  ||||||.:
Yeast     2 AGENPKKEGV--DARFAGIYSDPKFKNTKTKDHKIKLDSRFSKKDLEVQHKSK--VDKYGRKIKN 62

  Fly    95 --NKSNAEDLRKFYELDENESSSGEEPAKKESDLDSEAEAEQQERRAEERAIANLEKEESNDTLE 157
              |....||..|::|            .:.|:|.|||..|         :.:.:..:.|..|...
Yeast    63 AQNNRELEDFDKYFE------------KEAENDEDSEVNA---------KTVVDRARGEVPDDYV 106

  Fly   158 SDSSEVSQSLRQRLTNPEIDYARGEGRLYTDSSSDEDSDDEDEGPELQIDHVWGELDNDAEHTEE 222
            |.|.|.:.|                     ||.|..:|:.|.| .|.::     |::|....:.:
Yeast   107 SSSDEFTSS---------------------DSESSGESEVESE-EENEV-----EIENAKPESGD 144

  Fly   223 STRRLAVCNMDWDRIRAEDLMVMLSSFLPPGGSILSVKIYPSEFGKARMAEEEVHG-PKELVERV 286
            .::.|||.|:|||.:::||||:..|||:|.||.|..|.||||||||.||..|||.| ||||.::.
Yeast   145 ISKNLAVVNLDWDHVKSEDLMITFSSFVPKGGKIERVAIYPSEFGKERMQREEVEGPPKELFQKK 209

  Fly   287 EPEDDSDEELVRQQDSDA--------EEGE---DYHMEKLRQYQLNRLRYYYAVVECDSIDTADK 340
            .....|.::.....|||.        |||:   |.....||||||:|||||||:|.|....|:..
Yeast   210 NKNKTSKKKKTDDSDSDMDIGIKDLYEEGDADKDVDSRALRQYQLDRLRYYYAIVYCSDTTTSKA 274

  Fly   341 VYKECDGIEYESSATRVDLRFIPDDTSFEEDTPSDECFELPDASSYKPRQFTTTALQQAKVDLTW 405
            :|..|||.||||:|...|||::||..:|::|. .|||..||  .:|:|.||:|.|||.:.|.|||
Yeast   275 IYDNCDGTEYESTANMFDLRYVPDGMTFDDDV-RDECSILP--KNYRPHQFSTDALQHSSVKLTW 336

  Fly   406 DETALDRRELGDK-LSSGQVDKLTDKELRQIVAYSSEEEDSEAEESPAEEAAQKAVSEDPQKSKP 469
            |||..||.|:..: .:..::|   |.:.:..:|..|:|.|.:.:    |||..|
Yeast   337 DETPADRVEVAKRAFTQKEID---DMDFKAYLASDSDESDGQVD----EEAKNK----------- 383

  Fly   470 KKTSKQERIATYKNLLADILEQEKKE----KEQKYEMEMTWNVEPQHEEAQPEQQAQAELTPIEK 530
                       .|:|:.|.....|||    ::::.:||:|:.  |..|....:.....|.|.|||
Yeast   384 -----------LKSLVGDFGFNSKKETPNDEDEEVDMEITFT--PALEGGNEKSSEDKEETTIEK 435

  Fly   531 VIQKRSEKNRQRKEQRRQRQIEARGGDAGEDSDESMVPDGIDLNDAYFAEEFANGDYAPPKTKQD 595
            :.:|..|:.:.||::.::.:.::.                                    |.|:.
Yeast   436 IRRKEKERRKARKQKVKELKQQSE------------------------------------KDKKS 464

  Fly   596 KKKKKKKGKDDGEEDVEAKRQEK-ELELLLDDGDGRD------EKQHFSLTKILKKEEQEASGSK 653
            |.|...|...:.||::|...:.| |||||:||.|..:      .|.||::.:||:.|::
Yeast   465 KLKSVNKKHTNDEEEIEKNAKSKAELELLMDDDDDTETQGTINNKAHFNMNEILRSEKE------ 523

  Fly   654 RKRRQKLKKSKNQPQNAEKL-DDDFQVNLNDNRFSAVYKSHEYNIDPTHSHYKPTKGMQQIIGEK 717
                   |..|.:.|..|:: :|.|..:|.|.||..|::.|::.||||...:|.|:.|.:|:.|:
Yeast   524 -------KHKKGRYQKKERIVEDTFTPDLEDPRFKEVFEDHDFAIDPTQPEFKGTQAMSKILKER 581

  Fly   718 LKR--RKEQGEGGAAN---GDADGDEQVAPKRSKQQLEQNALVKSLKRK 761
            .||  .|::..||:.|   .:||.:|.:           ..||..||:|
Yeast   582 SKRVKNKKRKLGGSENNMTNNADDNEDI-----------GNLVNKLKKK 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11417	NP_569906.1	COG5638	44..763	CDD:227925	233/752 (31%)
CG11417	NP_569906.1	NUC153	683..711	CDD:285385	11/27 (41%)
ESF1	NP_010653.1	COG5638	1..608	CDD:227925	231/740 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345745
Domainoid	1	1.000	273	1.000	Domainoid score	I272
eggNOG	1	0.900	-	-		E1_COG5638
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	310	1.000	Inparanoid score	I475
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53646
OrthoFinder	1	1.000	-	-		FOG0004705
OrthoInspector	1	1.000	-	-		oto99634
orthoMCL	1	0.900	-	-		OOG6_103088
Panther	1	1.100	-	-	LDO	PTHR12202
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R416
SonicParanoid	1	1.000	-	-		X3307
TreeFam	1	0.960	-	-
	14	13.790