DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11417 and ESF1

DIOPT Version :9

Sequence 1:	NP_569906.1	Gene:	CG11417 / 31083	FlyBaseID:	FBgn0024364	Length:	771	Species:	Drosophila melanogaster
Sequence 2:	NP_001263309.1	Gene:	ESF1 / 51575	HGNCID:	15898	Length:	851	Species:	Homo sapiens

Alignment Length:	918	Identity:	307/918 - (33%)
Similarity:	448/918 - (48%)	Gaps:	258/918 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SENGIWQDSRFQHLLTDPRFRGVPKVQRKVKIDKRFQGMFTDDKFKVKYTVDKYGRPVNKSNAED 101
            |:..|..|.||:.:..||||..:|:..|||||||||:.||.|.|||:.|.|||.|||::.|..||
Human     3 SKQEIMSDQRFRRVAKDPRFWEMPEKDRKVKIDKRFRAMFHDKKFKLNYAVDKRGRPISHSTTED 67

  Fly   102 LRKFYELDENESS-SGEE--------------PAKKESDLDSEAEAEQQERRAEERAIANL---- 147
            |::||:|.:::|: |||:              ..|||.|..:..|.:::.::|..:...|.
Human    68 LKRFYDLSDSDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKANHKGSENKTDLD 132

  Fly   148 ---------------------------------EKEESN-------------------------- 153
                                             :||:.|
Human   133 NSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDSSLEEKQRTLDSGTSEIVK 197

  Fly   154 ---------------------------------------DTLESDSSEVSQSLRQRLTNPEI--- 176
                                                   |.||.||..||:......:..||
Human   198 SPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCDKDALEEDSESVSEIGSDEESENEITSV 262

  Fly   177 --------------------------------------DYARGEGRLYTDSSSDEDSDD---EDE 200
                                                  |.|||:|.:.|.|..::|:.|   |:.
Human   263 GRASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSDSGPDLARGKGNIETSSEDEDDTADLFPEES 327

  Fly   201 GPELQIDHVWGELDNDAEHTEESTRRLAVCNMDWDRIRAEDLMVMLSSFLPPGGSILSVKIYPSE 265
            |    .:|.|.|||.||...:|.|||||||||||||::|:||:.:.:||.|.||.|.||||||||
Human   328 G----FEHAWRELDKDAPRADEITRRLAVCNMDWDRLKAKDLLALFNSFKPKGGVIFSVKIYPSE 388

  Fly   266 FGKARMAEEEVHGPKELVERVEPEDDSDEELVRQQDSDAEEGEDYHMEKLRQYQLNRLRYYYAVV 330
            |||.||.||:|.||.||:...|               ||.|.:....||||.||..||:||||||
Human   389 FGKERMKEEQVQGPVELLSIPE---------------DAPEKDWTSREKLRDYQFKRLKYYYAVV 438

  Fly   331 ECDSIDTADKVYKECDGIEYESSATRVDLRFIPDDTSFEEDTPSDECFELPDASSYKPRQFTTTA 395
            :|||.:||.|:|::|||:|:|||.:.:||||||||.:| :|.|.|...|: :.::|||:.||:.|
Human   439 DCDSPETASKIYEDCDGLEFESSCSFIDLRFIPDDITF-DDEPKDVASEV-NLTAYKPKYFTSAA 501

  Fly   396 LQQAKVDLTWDETALDR-RELGDKLSSGQVDKLTDKELRQIVAYSSEEEDSEAEESPAEEAAQKA 459
            :..:.|::|||||..:| ..|..|...   ::|.|.:.:..:|.|||:|:...||...::...
Human   502 MGTSTVEITWDETDHERITMLNRKFKK---EELLDMDFQAYLASSSEDEEEIEEELQGDDGVN-- 561

  Fly   460 VSEDPQKSKPKKTSK--QERIATYKNLLADILEQEKKEKEQKYEMEMTW---NVEPQHEEAQPEQ 519
            |.||   .|.||:.|  :|:||.|:.||..|.|:|||.||...|||:.|   ..|...|..:.:.
Human   562 VEED---GKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKL 623

  Fly   520 QAQAELTPIEKVIQKRSEKNRQRKEQRRQRQIEARGGDAGEDSDESMVPDGIDLNDAYFAEEFAN 584
            :.:.:|||.|:.::|:.||.|.:::|:.          ..|::.|..:|..:||||.|||||
Human   624 EGKDKLTPWEQFLEKKKEKKRLKRKQKA----------LAEEASEEELPSDVDLNDPYFAEE--- 675

  Fly   585 GDYAPPKTKQ--DKKKKKKKGKD--DGEEDVEAKRQEKELELLLDDGDGRDEKQHFSLTKILKKE 645
                   .||  ..||..|..||  ..||::|.:||:.|:.||:.|.| .|.|:||:..||::.:
Human   676 -------VKQIGINKKSVKSAKDGTSPEEEIEIERQKAEMALLMMDED-EDSKKHFNYNKIVEHQ 732

  Fly   646 EQEASGSKRKRRQKLKKSKNQPQNAEKLDDDFQVNLNDNRFSAVYKSHEYNIDPTHSHYKPTKGM 710
            ..    ||:|::|.:||.       |.::|||:||:||.||.|:|.||.:|:||:..::|.||.|
Human   733 NL----SKKKKKQLMKKK-------ELIEDDFEVNVNDARFQAMYTSHLFNLDPSDPNFKKTKAM 786

  Fly   711 QQIIGEKLKR--RKEQGEGGAANGDADGDEQVAPKRSKQQLEQNA-----------LVKSLKRKI 762
            ::|:.||.::  ||||            :...|.|:.:.::|:.:           |:||:|.|.
Human   787 EKILEEKARQRERKEQ------------ELTQAIKKKESEIEKESQRKSIDPALSMLIKSIKTKT 839

  Fly   763 QLQQQGQK 770
            : |.|.:|
Human   840 E-QFQARK 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11417	NP_569906.1	COG5638	44..763	CDD:227925	302/902 (33%)
CG11417	NP_569906.1	NUC153	683..711	CDD:285385	13/27 (48%)
ESF1	NP_001263309.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	74..134		12/59 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	148..328		22/179 (12%)
		COG5638	301..836	CDD:227925	240/607 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..576		13/38 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	640..667		7/36 (19%)
		NUC153	759..787	CDD:285385	13/27 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	794..827		7/44 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157418
Domainoid	1	1.000	355	1.000	Domainoid score	I995
eggNOG	1	0.900	-	-		E1_COG5638
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5717
Inparanoid	1	1.050	401	1.000	Inparanoid score	I1930
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53646
OrthoDB	1	1.010	-	-		D1300279at2759
OrthoFinder	1	1.000	-	-		FOG0004705
OrthoInspector	1	1.000	-	-		oto90012
orthoMCL	1	0.900	-	-		OOG6_103088
Panther	1	1.100	-	-	LDO	PTHR12202
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R416
SonicParanoid	1	1.000	-	-		X3307
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800