DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11417 and Esf1

DIOPT Version :9

Sequence 1:	NP_569906.1	Gene:	CG11417 / 31083	FlyBaseID:	FBgn0024364	Length:	771	Species:	Drosophila melanogaster
Sequence 2:	NP_001094241.1	Gene:	Esf1 / 366203	RGDID:	1306067	Length:	842	Species:	Rattus norvegicus

Alignment Length:	891	Identity:	301/891 - (33%)
Similarity:	441/891 - (49%)	Gaps:	213/891 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SENGIWQDSRFQHLLTDPRFRGVPKVQRKVKIDKRFQGMFTDDKFKVKYTVDKYGRPVNKSNAED 101
            |:..|..|.||:.:..||||..:|:..|||||||||:.||.|.|||:.|.|||.|||::.|..||
  Rat     3 SKQEIMDDQRFRRVSKDPRFWEMPEKDRKVKIDKRFRAMFHDKKFKLNYAVDKRGRPISHSTTED 67

  Fly   102 LRKFYELDENESSSGEEPAKKESDLDSEAEAEQQERRAEERAIANLEKEESNDTLESDS------ 160
            |::||:|.:::|...:|.:|...:...:.:.:|.::..:.:.....:|:|:..|.:.||
  Rat    68 LKRFYDLSDSDSDLSDEESKVLDEKRVKEKKKQTKKETKSKTPIEEKKKETKKTDQKDSINKNDL 132

  Fly   161 --SEVSQSLRQRLTNPEID--------------------------YARGEGRLYT---------- 187
              ||..|.::....:|:||                          .|..:|:|.|
  Rat   133 NNSERIQKMKNSHKSPKIDSEVSPKDSEESLQSRKKKRDTTDLSVEASPKGKLRTKDPSTSAMVK 197

  Fly   188 ------------------------------------DSSS------------------------- 191
                                                ||:|
  Rat   198 SSTVSGSKAKREKQAVIMAKDNAGRMLHEEAPEEDSDSASELGRDEESEGEITSDDRASADDDEN 262

  Fly   192 -------------------DEDSDDEDEGPELQ-------------------------IDHVWGE 212
                               ||..|:.|.||:|.                         .:|.|.|
  Rat   263 EDEEEEEDGEEEEEEEEEEDESDDESDSGPDLARGKGNVETSSEDEDDLADLFPEEPGFEHAWRE 327

  Fly   213 LDNDAEHTEESTRRLAVCNMDWDRIRAEDLMVMLSSFLPPGGSILSVKIYPSEFGKARMAEEEVH 277
            ||.||...:|.|||||||||||||::|:||:.:.:||.|.||.:.|||||||||||.||.||::.
  Rat   328 LDKDAPRADEITRRLAVCNMDWDRLKAKDLLALFNSFKPKGGVVFSVKIYPSEFGKQRMKEEQIQ 392

  Fly   278 GPKELVERVEPEDDSDEELVRQQDSDAEEGEDYHMEKLRQYQLNRLRYYYAVVECDSIDTADKVY 342
            ||.||:...|               ||.|.:....||||.||..||:||||||||||.:||.|:|
  Rat   393 GPVELLSIPE---------------DAPEKDWASREKLRDYQFKRLKYYYAVVECDSPETASKIY 442

  Fly   343 KECDGIEYESSATRVDLRFIPDDTSFEEDTPSDECFELPDASSYKPRQFTTTALQQAKVDLTWDE 407
            ::|||:|:|||.:.:||||||||.:| :|.|.|...|: |.::|||:.||:.|:..:.|::||||
  Rat   443 EDCDGLEFESSCSFIDLRFIPDDITF-DDEPKDAASEV-DLTAYKPKYFTSAAMGTSTVEITWDE 505

  Fly   408 TALDR-RELGDKLSSGQVDKLTDKELRQIVAYSSEEEDSEAEESPAEEAAQKAVSEDPQKSKPKK 471
            |..:| ..|..|...   |:|.|.:....:|.|||:|: |.||:|..|   ..||.:..|:|..:
  Rat   506 TDHERITTLNRKFKK---DELLDMDFEAYLASSSEDEE-EVEEAPEGE---DGVSIEDGKTKKSQ 563

  Fly   472 TSKQERIATYKNLLADILEQEKKEKEQKYEMEMTW---NVEPQHEEAQPEQQAQAELTPIEKVIQ 533
            ...:|:||.|:.||..|.|:|||.||...|||:.|   ..|...|..:.:.:.:.:|||.|:.::
  Rat   564 KDDEEQIAKYRQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLE 628

  Fly   534 KRSEKNRQRKEQRRQRQIEARGGDAGEDSDESMVPDGIDLNDAYFAEEFANGDYAPPKTKQDKKK 598
            |:.||.|.:|:|:.          ..|::.|..:|..:||||.|||||.        |....|||
  Rat   629 KKKEKKRLKKKQKA----------LAEEASEDEIPSDVDLNDPYFAEEV--------KKIGIKKK 675

  Fly   599 KKKKGKD--DGEEDVEAKRQEKELELLLDDGDGRDEKQHFSLTKILKKEEQEASGSKRKRRQKLK 661
            ..|..||  ..||:.|.::|:.|:.||:.| :..|.|:||:..||::.:..    ||:|::|.:|
  Rat   676 SMKSAKDGATSEEETELEKQKAEMALLVMD-EEEDSKKHFNYDKIVEHQNL----SKKKKKQLMK 735

  Fly   662 KSKNQPQNAEKLDDDFQVNLNDNRFSAVYKSHEYNIDPTHSHYKPTKGMQQIIGEKLKRRKEQGE 726
            |.       |.|:|||:||::|.||.|:|.||.:|:||:..::|.||.|::|:.|| .|.:||.|
  Rat   736 KK-------ELLEDDFEVNVSDARFQAMYTSHLFNLDPSDPNFKKTKAMEKILEEK-ARHREQKE 792

  Fly   727 GGAANGDADGDEQVAPKRSKQQLEQ--NALVKSLKRKIQLQQQGQK 770
            ...........:.......||.::.  :.|:||:|.|.: |.|.:|
  Rat   793 ERLIQAVERAQQDTGKPAQKQPMDPALSMLIKSVKNKTE-QFQARK 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11417	NP_569906.1	COG5638	44..763	CDD:227925	296/875 (34%)
CG11417	NP_569906.1	NUC153	683..711	CDD:285385	13/27 (48%)
Esf1	NP_001094241.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	54..317		41/262 (16%)
		COG5638	293..827	CDD:227925	229/588 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	534..568		13/37 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	631..657		8/35 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	674..693		8/18 (44%)
		NUC153	750..778	CDD:285385	13/27 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	785..816		6/30 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351392
Domainoid	1	1.000	371	1.000	Domainoid score	I870
eggNOG	1	0.900	-	-		E1_COG5638
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5717
Inparanoid	1	1.050	418	1.000	Inparanoid score	I1757
OMA	1	1.010	-	-		QHG53646
OrthoDB	1	1.010	-	-		D1300279at2759
OrthoFinder	1	1.000	-	-		FOG0004705
OrthoInspector	1	1.000	-	-		oto97127
orthoMCL	1	0.900	-	-		OOG6_103088
Panther	1	1.100	-	-	LDO	PTHR12202
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3307
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810