DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11417 and esf1

DIOPT Version :9

Sequence 1:	NP_569906.1	Gene:	CG11417 / 31083	FlyBaseID:	FBgn0024364	Length:	771	Species:	Drosophila melanogaster
Sequence 2:	NP_595418.1	Gene:	esf1 / 2540076	PomBaseID:	SPBC1734.01c	Length:	682	Species:	Schizosaccharomyces pombe

Alignment Length:	800	Identity:	285/800 - (35%)
Similarity:	409/800 - (51%)	Gaps:	161/800 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKKKDKSGKLDKQTTKKEAPSSSQANMGKAAGANDSENGIWQDSRFQHLLTDPRFRGVPKVQRK 65
            ||||:.|             |.::::.         ||:.:..|.|||.:.:||||..:.:...|
pombe     1 MGKKQTK-------------PINAKSR---------SESNVVADPRFQSVHSDPRFSRLKRGNFK 43

  Fly    66 VKIDKRFQGMFTDDKFKVKYTVDKYGRPVNKSNA-EDLRKFYELDENESSSGEEPAKKESDLDSE 129
            ||:|:||:.:..|..||...:||:||||:|:..| :::.:.||| |||.||....:.:.:|.:..
pombe    44 VKVDERFKSLKEDKDFKTTASVDRYGRPLNQDKATKEIDRLYEL-ENEGSSSSSESSEITDNEEV 107

  Fly   130 AEAEQQERRAEERAIANLEKEESNDTLESDSSEVSQSLRQRLTNPEIDYARGEGRLYTDSSSDE- 193
            |.|..:..::||     |..|||.|      .||            .|.|||||.:.|..||||
pombe   108 ASASSKSTKSEE-----LTDEESED------EEV------------YDPARGEGIISTSESSDES 149

  Fly   194 DSDDEDEG-PELQIDHVWG-ELDNDAEHTEESTRRLAVCNMDWDRIRAEDLMVMLSSFLPPGGSI 256
            |::.|.|. ||  |..:.| |.:.:.....| |.||||.|||||.::|.||.|.||||.||||.:
pombe   150 DAESETEAQPE--ISELAGIEPEENIPRGSE-TNRLAVVNMDWDNLQAVDLFVALSSFCPPGGKL 211

  Fly   257 LSVKIYPSEFGKARMAEEEVHGP--------------KELVERVE-----PEDDSDEELVRQQDS 302
            |.|.||||||||:|||.|.|.||              .||.|..:     .|.|.|||     |:
pombe   212 LKVSIYPSEFGKSRMAAEHVQGPPRDIFTPADNQPSSAELHEAQKFGFDNNESDQDEE-----DA 271

  Fly   303 DAEE--GEDYHMEKLRQYQLNRLRYYYAVVECDSIDTADKVYKECDGIEYESSATRVDLRFIPDD 365
            ..||  |.::.|.|||||||.|||||||||||||:.||..:|:.|||.|||:||...||||||||
pombe   272 LIEEDLGNEFDMVKLRQYQLERLRYYYAVVECDSVRTAKVIYETCDGAEYETSANIYDLRFIPDD 336

  Fly   366 TSFEEDTPSDECFELPDASSYKPRQFTTTALQQAKVDLTWDETALDRRELGDKLSSGQVDKLTDK 430
            .:|::|...:.|.:.|:  .|:||.|.|.|||.:||.|:||.....|::|..|..:.|  .:.|.
pombe   337 VTFDDDESREVCTKAPE--KYEPRDFVTDALQHSKVKLSWDAEDPHRKDLIKKAFTSQ--DIEDL 397

  Fly   431 ELRQIVAYSSEEEDSEAEESPAEEAAQKAVSEDPQ----KSKPKKTSKQERIATYKNLLADILEQ 491
            :....:| |||.||.:.:  ......||.:|.|..    .|.|                   .|.
pombe   398 DFSAYIA-SSESEDEDVD--VIRSRYQKLLSGDADDFQANSNP-------------------FED 440

  Fly   492 EKKEKEQKYEMEMT----WNVEPQHEEAQPEQQAQAELTPIEKVIQKRSEKNRQRKEQRRQRQIE 552
            :.|.:....|||:|    ::|:.....::.::      |.|||..:|.:|:.::|||   .||::
pombe   441 DDKLEGANGEMEVTFTSGFDVDNNANSSEKDE------TTIEKYKRKAAERKQRRKE---LRQLK 496

  Fly   553 ARGGDAGEDSDESMVPDGIDL--NDAYFAEEFANGDYAPPKTKQDKKKKKKKGKDDGEEDVEAKR 615
            ....|.||.||       :||  :|.:|.::.|:.:          .||.||||....||..|..
pombe   497 KTKDDEGEGSD-------VDLGFDDPFFKDKDASRN----------NKKNKKGKHTQIEDPTAAS 544

  Fly   616 QEKELELLLDDGDGRDEKQHFSLTKILKKEEQEASGSKRKRRQKLKKSKNQPQNAEKLDDDFQVN 680
            :|:...|:.:|.:..::..||.:..|||.|       |.|:.:||||   :..|.|.|.:.|:.:
pombe   545 KEELENLVREDENDSEQLDHFDMKSILKAE-------KFKKNRKLKK---KASNLEGLQEGFEAD 599

  Fly   681 LNDNRFSAVYKSHEYNIDPTHSHYKPTKGMQQIIGEKLKRRKEQGEGGAANGDADGDEQVAPKRS 745
            ::|.||:|:|.:|.:.:|||:.|:|.||.:::|:.|..|||..|.|     ...||..::..|:.
pombe   600 VSDPRFAALYTNHNFALDPTNPHFKRTKTVEKIMDESRKRRSNQLE-----QTQDGKPELKIKKR 659

  Fly   746 K-----QQLEQNALVKSLKR 760
            |     |:.|.:.:|||:||
pombe   660 KAEKGDQRQELDRIVKSIKR 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11417	NP_569906.1	COG5638	44..763	CDD:227925	276/756 (37%)
CG11417	NP_569906.1	NUC153	683..711	CDD:285385	13/27 (48%)
esf1	NP_595418.1	COG5638	10..682	CDD:227925	278/777 (36%)
esf1	NP_595418.1	NUC153	602..630	CDD:285385	13/27 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	325	1.000	Domainoid score	I218
eggNOG	1	0.900	-	-		E1_COG5638
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	376	1.000	Inparanoid score	I431
OMA	1	1.010	-	-		QHG53646
OrthoFinder	1	1.000	-	-		FOG0004705
OrthoInspector	1	1.000	-	-		oto101268
orthoMCL	1	0.900	-	-		OOG6_103088
Panther	1	1.100	-	-	LDO	PTHR12202
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R416
SonicParanoid	1	1.000	-	-		X3307
TreeFam	1	0.960	-	-
	13	12.860