DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG12773 and SLC12A6

DIOPT Version :10

Sequence 1:NP_569905.1 Gene:CG12773 / 31082 FlyBaseID:FBgn0024365 Length:712 Species:Drosophila melanogaster
Sequence 2:NP_598408.1 Gene:SLC12A6 / 9990 HGNCID:10914 Length:1150 Species:Homo sapiens


Alignment Length:578 Identity:149/578 - (25%)
Similarity:242/578 - (41%) Gaps:154/578 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 GDE--DGDVAVTSFRQRTNNNTGGFVDLGNEYT-YAAGGHHASGANEIFAGEQGDKPWWRSNFFI 86
            |||  |.::|:......|.......::....|| ...|......|..|..|::  ||        
Human   125 GDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKK--KP-------- 179

  Fly    87 SQPVLFGTWDGVFTSCLINVFGVIVFLRSGWIVAQAGILNAVLIIF----CTVVIAL-VSVLSAI 146
            ::....||:.||:..||.|:||||:|||..|:|..||:|.|..|:.    ||::.|: :|.::..
Human   180 TKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATN 244

  Fly   147 GICERCRVESGGVYFLIAHTLGSRFGGALGLLYCFGQAVGCALNVMG------------------ 193
            |:     |.:||.||:|:..||..||||:||.:..|.....|:.::|                  
Human   245 GV-----VPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHS 304

  Fly   194 ---FGESMAGLVGLEGSKWAIRGFATAAVLLLGCINVAGVKWVIKLQFILLMILLISALDFMVGS 255
               ..||.|.|..:       |.:.||.::|:..:...||::|.|...:.|..:::|.|....|:
Human   305 DDALKESAAMLNNM-------RVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGA 362

  Fly   256 ---------------------------------------------FTSEASGGFN---------- 265
                                                         |...:|..||          
Human   363 IKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHN 427

  Fly   266 ---------GWASGNFVENLWPKY----------------------------DDGYSWFRVFGVF 293
                     |.|||...||||..|                            |...|:..:.|:|
Human   428 NVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVDITTSFTLLVGIF 492

  Fly   294 FPTVTGVLSGINMSGDLRAPSTDIPNGTLAAFGTSTFLYLVFVLFLGATCQRSFLYTDYMISVKV 358
            ||:|||:::|.|.||||:.....||.||:.|..|::|:||..|:..||..:...|...:..:||.
Human   493 FPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKG 557

  Fly   359 SAV--------HFLLLAGIYVSSMSSCLGAMYGTPRVLQSIAKESVIPGIDILGKGRGPNKVPLY 415
            :.|        .::::.|.:.|:..:.|.::.|.||:||:|||:::||.:.:.|..:. |..|.:
Human   558 NLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEPTW 621

  Fly   416 AMAIVALVTVTFIIVGDINFLAPIVTMPFLLTYACIDYAYFALAQTFDIQEQREERFR 473
            |:.:.|.:....|::..::.:|||::|.||:.|..::.|  ...||.........|||
Human   622 ALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLA--CALQTLLRTPNWRPRFR 677

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12773NP_569905.1 AA_permease_2 88..>456 CDD:459263 130/493 (26%)
SLC12A6NP_598408.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 20..66
2a30 109..1150 CDD:273347 149/578 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 161..181 6/29 (21%)
Scissor helix. /evidence=ECO:0000269|PubMed:33199848, ECO:0000269|PubMed:34031912, ECO:0007744|PDB:6M1Y, ECO:0007744|PDB:6Y5R, ECO:0007744|PDB:6Y5V, ECO:0007744|PDB:7AIN, ECO:0007744|PDB:7AIO, ECO:0007744|PDB:7D90, ECO:0007744|PDB:7NGB 682..691
Interaction with CKB. /evidence=ECO:0000269|PubMed:18566107 1133..1150
Blue background indicates that the domain is not in the aligned region.

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