DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12773 and SLC12A8

DIOPT Version :9

Sequence 1:	NP_001284773.1	Gene:	CG12773 / 31082	FlyBaseID:	FBgn0024365	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_001182412.2	Gene:	SLC12A8 / 84561	HGNCID:	15595	Length:	714	Species:	Homo sapiens

Alignment Length:	723	Identity:	280/723 - (38%)
Similarity:	412/723 - (56%)	Gaps:	104/723 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 SGANEIF--AGEQG----DKPWWRSNFFISQPVLFGTWDGVFTSCLINVFGVIVFLRSGWIVAQA 122
            |...|:|  |.:|.    .:|||::..|:.:||||||||||||||:||:|||::|||:||:|...
Human     5 SQVQELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNT 69

  Fly   123 GILNAVLIIFCTVVIALVSVLSAIGICERCRVESGGVYFLIAHTLGSRFGGALGLLYCFGQAVGC 187
            |:|..:.::...:::|||:|||.||:.||..:.|||||.:|:..||.:.||.:||||.|||.|..
Human    70 GVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAG 134

  Fly   188 ALNVMGFGESMAGLVGLEGSKWAIRGFATAAVLLLGCINVAGVKWVIKLQFILLMILLISALDFM 252
            |:.:.||.||::.|:|| |:.||:||.:.|.:|.|..||:|||||:|:||.:||.:|.:|.|||:
Human   135 AMYITGFAESISDLLGL-GNIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDFV 198

  Fly   253 VGSFTS-EASGGFNGWASGNFVENLWPKYDDGYSWFRVFGVFFPTVTGVLSGINMSGDLRAPSTD 316
            |||||. :...||.|::......|..|.|..|.|:|.|||||||..|||::|.||.||||.|:..
Human   199 VGSFTHLDPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVFFPAATGVMAGFNMGGDLREPAAS 263

  Fly   317 IPNGTLAAFGTSTFLYLVFVLFLGATCQRSFLYTDYMISVKVSAVHFLLLAGIYVSSMSSCLGAM 381
            ||.|:|||.|.|.|||::||..|||.|.|..|..|::|:.|||.:.||.|.|:|:||::||:|.:
Human   264 IPLGSLAAVGISWFLYIIFVFLLGAICTREALRYDFLIAEKVSLMGFLFLLGLYISSLASCMGGL 328

  Fly   382 YGTPRVLQSIAKESVIPGIDILGKGRGPNKVPLYAMAIVALVTVTFIIVGDINFLAPIVTMPFLL 446
            ||.||:||.||:|.|||.:..||:|:||||.|:.|:.:.:|||:.|:.||.:|.||||||:.|:|
Human   329 YGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFML 393

  Fly   447 TYACIDYAYFALAQTF---------DIQEQRE-----ERFRIQASSPSYETR------RYGSVSD 491
            ||..:||:||:|:...         .::|..|     |...:: .:|||.:.      ..|::.:
Human   394 TYVAVDYSYFSLSMCSCSLTPVPEPVLREGAEGLHCSEHLLLE-KAPSYGSEGPAQRVLEGTLLE 457

  Fly   492 TGNDLDLLF-------------------PDRVRHK---------------NLQSPQNSPLHQTVP 522
            ...|:|.|.                   |:..:.|               :|:||      .:.|
Human   458 FTKDMDQLLQLTRKLESSQPRQGEGNRTPESQKRKSKKATKQTLQDSFLLDLKSP------PSFP 516

  Fly   523 LEFDNEGPSTSNQAQSS--ERRTGHEADTTLAVEQAVAQAGVEQDQGDEAEPIAP---------- 575
            :|..:..|:.|.:.|.|  .::|.....|              |.:|...|.:.|
Human   517 VEISDRLPAASWEGQESCWNKQTSKSEGT--------------QPEGTYGEQLVPELCNQSESSG 567

  Fly   576 ---------IRPPIHSKTKNWYSGYCNRWASLLGAFTKLLVMLLVNWYYALTCFLVVFVVWFYVG 631
                     ....:..::.::|:..||.|.|||||...||:|.::.|.|.|....|..:|:||:|
Human   568 EDFFLKSRLQEQDVWRRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIG 632

  Fly   632 TANPAVKPGLTAEFNFFAWLKSVIFRCFGKRMNEYEQIVVTPSCPGVDLSPTQLNEQNEDFRPRP 696
            .|:|.:..|..:.|:||.|::|::........:..|||::.||...||:..|||.::|.||..|.
Human   633 RASPGLHLGSASNFSFFRWMRSLLLPSCRSLRSPQEQIILAPSLAKVDMEMTQLTQENADFATRD 697

  Fly   697 NYHHSSVI 704
            .|||||::
Human   698 RYHHSSLV 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12773	NP_001284773.1	2a30	88..>456	CDD:273347	194/368 (53%)
SLC12A8	NP_001182412.2	2a30	35..>407	CDD:273347	197/372 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	471..503		2/31 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	530..550		5/33 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145611
Domainoid	1	1.000	392	1.000	Domainoid score	I780
eggNOG	1	0.900	-	-		E2759_KOG2083
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11628
Inparanoid	1	1.050	510	1.000	Inparanoid score	I1330
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48035
OrthoDB	1	1.010	-	-		D344013at33208
OrthoFinder	1	1.000	-	-		FOG0007328
OrthoInspector	1	1.000	-	-		oto91384
orthoMCL	1	0.900	-	-		OOG6_108582
Panther	1	1.100	-	-	LDO	PTHR11827
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3761
SonicParanoid	1	1.000	-	-		X5443
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800