Protein Alignment CG12773 and SLC12A3

DIOPT Version :9

• Sequence 1: NP_001284773.1
• Gene: CG12773 / 31082
• FlyBaseID: FBgn0024365
• Length: 712
• Species: Drosophila melanogaster
• Sequence 2: NP_000330.3
• Gene: SLC12A3 / 6559
• HGNCID: 10912
• Length: 1030
• Species: Homo sapiens
• Alignment Length: 658
• Identity: 171/658 - (25%)
• Similarity: 279/658 - (42%)
• Gaps: 184/658 - (27%)

  Fly    88 QPVLFGTWDGVFTSCLINVFGVIVFLRSGWIVAQAGILNAVLIIFCTVVIALVSVLSAIGICERC 152
            :||.||...||...|::|::|||::||..||.|||||:...:||..:|.:..::.||...|....
Human   132 EPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNG 196

  Fly   153 RVESGGVYFLIAHTLGSRFGGALGLLYCFGQAVGCALNVMGFGESMAGLVGLEGSKWA-----IR 212
            :|:|||.||||:.:||...||::||::.|..|||.|::.:||.|::..|:...|:...     ||
Human   197 KVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGAPIVDPINDIR 261

  Fly   213 GFATAAVLLLGCINVAGVKWVIKLQFILLMILLISALDFMVGSF----TSEASGGFNGWASGNFV 273
            ..|..:|.:|..|::||::|..|.|.:..:::::|..:::||:.    ..:||.||..:.:..||
Human   262 IIAVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSEDKASKGFFSYRADIFV 326

  Fly   274 ENLWPKY--DDGYSWFRVFGVFFPTVTGVLSGINMSGDLRAPSTDIPNGTLAAFGTSTFLYLVFV 336
            :||.|.:  .|| ::|.:|.:|||:.||:|:|.|:||||:.|:..||.|||.|...:|..||...
Human   327 QNLVPDWRGPDG-TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAIS 390

  Fly   337 LFLGA------------------------TCQRSFLYTD--------------YMISVKVSAVHF 363
            ..:|:                        .|...:.:|:              |.....||....
Human   391 ATIGSCVVRDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAP 455

  Fly   364 LLLAGIYVSSMSSCLGAMYGTPRVLQSIAKESVIPGIDILGKGRGPNKVPLYAMAIVALVTVTFI 428
            |:.|||:.:::||.|..:....:|.|.:.::.:.|.|...|||.|.||.|:....:...:.|.||
Human   456 LITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFI 520

  Fly   429 IVGDINFLAPIVTMPFLLTYACIDYAYFALAQTFDIQEQREERFRIQASSPSYETRRYGSVSDTG 493
            |:.::|.:|||::..||.:||.|:::.|..:.|               :||.:
Human   521 IIAELNTIAPIISNFFLCSYALINFSCFHASIT---------------NSPGW------------ 558

  Fly   494 NDLDLLFPDRVRHKNLQSPQNSPLHQTVPLEFDNEGPSTSNQAQSSERRTGHEADTTLAVEQAVA 558
                                                                             
Human   559 ----------------------------------------------------------------- 558

  Fly   559 QAGVEQDQGDEAEPIAPIRPPIHSKTKNWYSGYCNRWASLLGAFTKLLVMLLVNWYYALTCFLVV 623
                              ||...         |.|:||:|.||...:::|.|:.|:.||....||
Human   559 ------------------RPSFQ---------YYNKWAALFGAIISVVIMFLLTWWAALIAIGVV 596

  Fly   624 FVVWFYVGTANPAVKPGLTAEFNFFAWLKSVIFRCFGKRMNEYEQIV--VTPSCPGVDLSPTQLN 686
            ..:..||....|.|..|.:.:...:....|     :...:||.|..:  ..|.|..:...|
Human   597 LFLLLYVIYKKPEVNWGSSVQAGSYNLALS-----YSVGLNEVEDHIKNYRPQCLVLTGPP---- 652

  Fly   687 EQNEDFRP 694
                :|||
Human   653 ----NFRP 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12773	NP_001284773.1	2a30	88..>456	CDD:273347	136/416 (33%)
SLC12A3	NP_000330.3	2a30	59..1029	CDD:273347	171/658 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2083
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810