DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12773 and nkcc-1

DIOPT Version :9

Sequence 1:	NP_001284773.1	Gene:	CG12773 / 31082	FlyBaseID:	FBgn0024365	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_001255790.1	Gene:	nkcc-1 / 3565648	WormBaseID:	WBGene00012543	Length:	1235	Species:	Caenorhabditis elegans

Alignment Length:	729	Identity:	187/729 - (25%)
Similarity:	297/729 - (40%)	Gaps:	209/729 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VDWQRFGLGGDEDGDVAVTSFRQRTNNNTGGFVDLGNEYTYAAGGHH---ASGANEIFAGEQGDK 77
            :|:.|..:  |.||.....|..|..:.......|||.|...|.  ||   .|..:|       .|
Worm   172 IDFYRNSI--DTDGVFNRPSMAQLIHGKEHKEQDLGFEELNAQ--HHHLEDSPVHE-------TK 225

  Fly    78 PWWRSNFFISQP----VLFGTWDGVFTSCLINVFGVIVFLRSGWIVAQAGILNAVLIIFCTVVIA 138
            ..:|.....:.|    |.||...|||..||:|:|||:::||..|:..|||:.....|:....|:.
Worm   226 NEYRMEKMHAPPSQNRVKFGWIQGVFVRCLLNIFGVMLYLRVSWVSGQAGVGLGSCIVLLASVVT 290

  Fly   139 LVSVLSAIGICERCRVESGGVYFLIAHTLGSRFGGALGLLYCFGQAVGCALNVMGFGESMAGL-- 201
            .::.||...||....|:.||.||||:.:||..|||::|:::....|||.|:.::||.||...:
Worm   291 TITALSTCAICTNGDVKGGGAYFLISRSLGPEFGGSIGIIFSIANAVGAAMYIVGFAESFRDVLI 355

  Fly   202 ---VG--LEGSKWAIR--GFATAAVLLLGCINVAGVKWVIKLQFILLMILLISALDFMVGSF--- 256
               :|  .:|..|.:|  ||.| .|:|:|.:.: |.::..|:|..||:|||:|..:::.|||
Worm   356 DYNIGTIFDGGLWDVRVIGFVT-CVILMGIVFI-GSEFESKMQLGLLVILLVSIANYVFGSFFPP 418

  Fly   257 -TSEASGGFNGWASGNFVENLWPKYDDGYSWFRVFGVFFPTVTGVLSGINMSGDLRAPSTDIPNG 320
             ....:.|..|::......|..|.:.:..::|.||.|:||..||:::|.|:||||..|...||.|
Worm   419 NEIAMNRGATGYSLDTLQSNFMPHFTENNTFFSVFSVYFPAATGIMAGANISGDLANPQQAIPLG 483

  Fly   321 TLAAFGTSTFLYLVFVLFLGAT--------------------------CQRSFLYTDYMISVKVS 359
            ||.|...:|.:||:.|...|:|                          |  .|....|...|::|
Worm   484 TLLAILVTTIVYLLTVWMTGSTVVAFSNGTEPAVFNNSYFVPPDCTPDC--PFGLVSYYQVVEMS 546

  Fly   360 AVHF---LLLAGIYVSSMSSCLGAMYGTPRVLQSIAKESVIPGIDILGKGRGPNKVPLYAMAIVA 421
            :  |   |:.|||:.:::||.|.::...|:|.|::.|:.:.|.||...|..|.|:.|..|..:..
Worm   547 S--FWGPLITAGIFAATLSSALASLVSAPKVFQAVCKDRLFPRIDYFAKTYGKNEEPKRAYVLGF 609

  Fly   422 LVTVTFIIVGDINFLAPIVTMPFLLTYACIDYAYFALAQTFDIQEQREERFRIQASSPSYETRRY 486
            .:.:..:.:||:|.:|||::..||.:||.|:||.|  .|:|             |.||.:
Worm   610 FLAMGIVAIGDLNVIAPIISNFFLGSYALINYACF--DQSF-------------ADSPGF----- 654

  Fly   487 GSVSDTGNDLDLLFPDRVRHKNLQSPQNSPLHQTVPLEFDNEGPSTSNQAQSSERRTGHEADTTL 551

Worm   655 ----------------------------------------------------------------- 654

  Fly   552 AVEQAVAQAGVEQDQGDEAEPIAPIRPPIHSKTKNWYSGYCNRWASLLGAFTKLLVMLLVNWYYA 616
                                     ||..         .|.|.|.||:||...:.||.:::|:.|
Worm   655 -------------------------RPGF---------TYYNMWISLVGALLCVFVMFIIDWFSA 685

  Fly   617 LTCFLVVFVVWFYVGTANPAVKPGLTAEFNFFAWLKSVIFRCFGKRMNEYEQIVVTPSCPGVDLS 681
            |..|.....::.|:....|.|..|.:.:.:.:....|.:                      :.||
Worm   686 LVTFFCFGAIFMYLLHRKPDVNWGSSTQAHSYKNALSAM----------------------IKLS 728

  Fly   682 PTQLNEQNEDFRPR 695
            .|:  |..:::||:
Worm   729 TTE--EHVKNYRPQ 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12773	NP_001284773.1	2a30	88..>456	CDD:273347	137/413 (33%)
nkcc-1	NP_001255790.1	2a30	165..1235	CDD:273347	187/729 (26%)
		SLC5-6-like_sbd	<323..686	CDD:294310	121/487 (25%)
		SLC12	751..1235	CDD:281515
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910