Protein Alignment CG12773 and Slc12a8

DIOPT Version :10

• Sequence 1: NP_569905.1
• Gene: CG12773 / 31082
• FlyBaseID: FBgn0024365
• Length: 712
• Species: Drosophila melanogaster
• Sequence 2: NP_705889.2
• Gene: Slc12a8 / 266733
• RGDID: 628730
• Length: 705
• Species: Rattus norvegicus
• Alignment Length: 705
• Identity: 282/705 - (40%)
• Similarity: 405/705 - (57%)
• Gaps: 84/705 - (11%)

  Fly    68 EIF--AGEQG----DKPWWRSNFFISQPVLFGTWDGVFTSCLINVFGVIVFLRSGWIVAQAGILN 126
            |:|  |.:||    .:|||:...|:.:||||||||||||||:||:|||::|||:||:|...|:|.
  Rat     8 ELFHEAAQQGALARSQPWWKIQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLL 72

  Fly   127 AVLIIFCTVVIALVSVLSAIGICERCRVESGGVYFLIAHTLGSRFGGALGLLYCFGQAVGCALNV 191
            .:|::...:::||::|||.||:.|...:.|||||.:|:..||.:.||.:||||.|||.|..|:.:
  Rat    73 GLLLVSFVILVALITVLSGIGVAEHGWMGSGGVYSMISSVLGGQMGGTVGLLYVFGQCVAGAMYL 137

  Fly   192 MGFGESMAGLVGLEGSKWAIRGFATAAVLLLGCINVAGVKWVIKLQFILLMILLISALDFMVGSF 256
            .||.||::.|:|| |:.||:||.:.|.:|.|..||:|||||:|:||.:||.:|.:|.|||:||||
  Rat   138 TGFAESISDLLGL-GNIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLSLLAVSTLDFVVGSF 201

  Fly   257 TS-EASGGFNGWASGNFVENLWPKYDDGYSWFRVFGVFFPTVTGVLSGINMSGDLRAPSTDIPNG 320
            |. :...||.|::......|:.|:|..|.|:|.|||||||..|||::|.||.||||.|:..||.|
  Rat   202 THLDPEHGFIGYSPELLQSNILPEYSPGESFFTVFGVFFPAATGVMAGFNMGGDLREPADSIPLG 266

  Fly   321 TLAAFGTSTFLYLVFVLFLGATCQRSFLYTDYMISVKVSAVHFLLLAGIYVSSMSSCLGAMYGTP 385
            :|||.|.|.|||::|...|||.|.|..|.:|::|:.|||.|.||.|.|:|:||::||:|.:||.|
  Rat   267 SLAAVGISWFLYIIFAFLLGAVCTREALRSDFLIAEKVSLVGFLFLLGLYISSLASCMGGLYGAP 331

  Fly   386 RVLQSIAKESVIPGIDILGKGRGPNKVPLYAMAIVALVTVTFIIVGDINFLAPIVTMPFLLTYAC 450
            |:||.||::.|||.:..||.|:||||.|:.|:.:.:|||:.|::||.:|.|||:||:.|:|||..
  Rat   332 RILQCIAQDKVIPALAFLGNGKGPNKTPVAAICLTSLVTMAFVLVGQVNVLAPVVTINFMLTYIA 396

  Fly   451 IDYAYFALAQTFDIQEQREE-------------RFRIQASSPSYETRRYGSVSDTGN-------- 494
            :||:||||:.......|..|             ...:|..:||     |||.:..|:
  Rat   397 VDYSYFALSMAHCGLAQSPEPMPRQGPDALHCSEHLLQDKAPS-----YGSDTPAGSLSEGTLLE 456

  Fly   495 ---DLD-LLFP-----DRVRHKNLQSPQNSPLH-------QTVPLEF--DNEGPSTSNQAQSSER 541
               |:| ||.|     .:.|.:::.....|..|       ||:...|  |.|.|.:.:.. :|||
  Rat   457 FTKDMDQLLQPIGGLESQPRSRDVNQVLKSQKHKCKKDAKQTLQDSFLLDAESPLSFSMG-ASER 520

  Fly   542 RTGHEADTTLAVEQAVAQAGVEQDQGDEAEPIAPIRP----------------------PIHSKT 584
                     |:|.....|...:..|...:|....:.|                      .:..:.
  Rat   521 ---------LSVASCGEQESYQNQQTSRSESHDHLVPDLCTQPRANGEDFFLKCRLQEQQVQRRP 576

  Fly   585 KNWYSGYCNRWASLLGAFTKLLVMLLVNWYYALTCFLVVFVVWFYVGTANPAVKPGLTAEFNFFA 649
            ..:|...||.|.|||||...||:|.::.|.|.|....|..:|:.|:|.|:|.:..|..:.|:||.
  Rat   577 SAFYVCMCNPWVSLLGALASLLIMFVIQWLYTLASMGVAALVYLYIGQASPGLYLGSASNFSFFQ 641

  Fly   650 WLKSVIFRCFGKRMNEYEQIVVTPSCPGVDLSPTQLNEQNEDFRPRPNYHHSSVI 704
            |:||.:........:..|||::.||...||::.|||.:.|.||..|..||.||.:
  Rat   642 WMKSFLVPSCRSLRSTREQIILAPSPAKVDMAMTQLTQDNADFATRDRYHRSSFL 696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12773	NP_569905.1	AA_permease_2	88..>456	CDD:459263	191/368 (52%)
Slc12a8	NP_705889.2	AA_permease_2	34..>420	CDD:459263	197/386 (51%)