DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12773 and Slc12a4

DIOPT Version :9

Sequence 1:	NP_001284773.1	Gene:	CG12773 / 31082	FlyBaseID:	FBgn0024365	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_001240733.1	Gene:	Slc12a4 / 20498	MGIID:	1309465	Length:	1087	Species:	Mus musculus

Alignment Length:	763	Identity:	170/763 - (22%)
Similarity:	278/763 - (36%)	Gaps:	282/763 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SEGNGNGGRR-------TVDWQRFGLGGD-EDGDVAV----TSFRQRTNNNTGGFVDLGNEYTYA 57
            |:|.|.|..|       .:|..|   |.| .|.::|:    ...|.:.::..|..|...| .|..
Mouse    37 SDGEGQGNHRENSPFLCPLDASR---GNDYYDRNLALFEEELDIRPKVSSLLGKLVSYTN-LTQG 97

  Fly    58 AGGHHASGANEIFAGEQGDKPWWRSNFFISQPVLFGTWDGVFTSCLINVFGVIVFLRSGWIVAQA 122
            |..|     .|..:||.|.:.       .::....||..||:..||.|:||||:|||..|:|..|
Mouse    98 AKEH-----EEAESGEGGRRR-------AAKAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTA 150

  Fly   123 GILNAVLIIF----CTVVIAL-VSVLSAIGICERCRVESGGVYFLIAHTLGSRFGGALGLLYCFG 182
            |:|.|:||:.    ||::.|: :|.::..|:     |.:||.||:|:.:||..||||:||.:..|
Mouse   151 GVLQALLIVLICCCCTLLTAISMSAIATNGV-----VPAGGSYFMISRSLGPEFGGAVGLCFYLG 210

  Fly   183 QAVGCALNVMGFGESMAGLV----------GLEGSKWA----IRGFATAAVLLLGCINVAGVKWV 233
            .....|:.::|..|.:...:          |......|    :|.:.|..:.|:..:...|||:|
Mouse   211 TTFAAAMYILGAIEILLTYIAPPAAIFYPSGTHDMSSATLNNMRVYGTIFLTLMTLVVFVGVKYV 275

  Fly   234 IKLQFILLMILLISALDFMVG-------------------------------------------- 254
            .|...:.|..::||.|....|
Mouse   276 NKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTVVVDNETVATRL 340

  Fly   255 --------SFTSEASG------------GFNGWASGNFVENLWPKY------------------- 280
                    :.|:::..            |..|.|:|...||||..|
Mouse   341 WTFFCHSPNLTADSCDPYFLLNNVTEIPGIPGAAAGVLQENLWSAYLEKGEVVEKHGLPSTDTLG 405

  Fly   281 -----------DDGYSWFRVFGVFFPTVTGVLSGINMSGDLRAPSTDIPNGTLAAFGTSTFLYLV 334
                       |...|:..:.|:|||:|||:::|.|.|||||.....||.||:.|..|::.:|..
Mouse   406 LKESLSLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIVTTSLVYFS 470

  Fly   335 FVLFLGATCQRSFLYTDYMISVKVSAV--------HFLLLAGIYVSSMSSCLGAMYGTPRVLQSI 391
            .|:..||..:...|...|...|..:.|        .::::.|.:.|:..:.|.::.|.||:||:|
Mouse   471 SVILFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVVGSFFSTCGAGLQSLTGAPRLLQAI 535

  Fly   392 AKESVIPGIDILGKGRGPNKVPLYAMAIVALVTVTFIIVGDINFLAPIVTMPFLLTYACIDYAYF 456
            ||:::||.:.:.|.|:. |..|.:|:.:.||:....|::..::.:|||::|.||:.|..::.|
Mouse   536 AKDNIIPFLRVFGHGKA-NGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLA-- 597

  Fly   457 ALAQTFDIQEQREERFRIQASSPSYETRRYGSVSDTGNDLDLLFPDRVRHKNLQSPQNSPLHQTV 521

Mouse   598 ----------------------------------------------------------------- 597

  Fly   522 PLEFDNEGPSTSNQAQSSERRTGHEADTTLAVEQAVAQAGVEQDQGDEAEPIAPIRPPIHSKTKN 586
                                         .||:..:                         :|.|
Mouse   598 -----------------------------CAVQTLL-------------------------RTPN 608

  Fly   587 W---YSGYCNRWA-SLLGAFTKLLVMLLVNWYYALTCFLVVFVVWFYV 630
            |   :..|  .|. |.||....|.:|.:.:|||||...|:..:::.|:
Mouse   609 WRPRFKYY--HWTLSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYI 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12773	NP_001284773.1	2a30	88..>456	CDD:273347	129/488 (26%)
Slc12a4	NP_001240733.1	2a30	44..1087	CDD:273347	166/756 (22%)
		SLC5-6-like_sbd	144..>305	CDD:294310	46/165 (28%)
		SLC12	711..1087	CDD:281515
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910