DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12773 and T04B8.5

DIOPT Version :9

Sequence 1:	NP_001284773.1	Gene:	CG12773 / 31082	FlyBaseID:	FBgn0024365	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_001022305.1	Gene:	T04B8.5 / 173453	WormBaseID:	WBGene00020207	Length:	952	Species:	Caenorhabditis elegans

Alignment Length:	537	Identity:	140/537 - (26%)
Similarity:	237/537 - (44%)	Gaps:	115/537 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GDVAVTSFRQRTNNNTGGFVDLGNEYTYAAGGHHASGANEIFAGEQGDKPWWRS----------- 82
            |..::||:        ||.|   || .|..||    |..|| .||.|..|...:
Worm    10 GAPSMTSY--------GGIV---NE-MYDGGG----GDAEI-PGENGKSPKKGAVPLIDEESQST 57

  Fly    83 ----------------NFFISQPVLFGTWDGVFTSCLINVFGVIVFLRSGWIVAQAGILNAVLII 131
                            .|..|:|....|..|||....:::|.:::|||.|::|.|.|.|..:|.:
Worm    58 PRGSTSGDGGGGSPSMEFSSSRPGGLSTISGVFAPVALSMFSILLFLRMGFVVGQLGFLMTILQL 122

  Fly   132 FCTVVIALVSVLSAIGICERCRVESGGVYFLIAHTLGSRFGGALGLLYCFGQAVGCALNVMGFGE 196
            .....|.:::|||...|.....||.||||::|:.:||..||||:|:|:.......|||.:.||.|
Worm   123 AMAYAIVMLTVLSLCAISSNGAVEGGGVYYMISRSLGPEFGGAIGVLFFVANVFSCALYISGFTE 187

  Fly   197 SMAGLVG----LEGSKW---------------AIRG---FATAAVLLLGCINVAGVKWVIKLQF- 238
            ::...:|    .:...|               ::.|   ||..|::....|:|....|::.:.|
Worm   188 ALMNNIGNGQFPDSPAWRFVYCVLVSLVLLVLSLLGSALFAKTALITFVLISVCYGTWIVSVIFN 252

  Fly   239 ----ILL-------MILLISALDFMVGS---FTSEASGGFNGWASGNFVENLWPKYDDGYS---- 285
                :|:       ..:|::|.|...|:   |....:..:.||:.....||::|:|...|:
Worm   253 GRMEVLIPKVNTPAYRVLVNASDPSQGTVEDFNQTLTANYTGWSFHTLGENMFPEYTMDYTTEKP 317

  Fly   286 --WFRVFGVFFPTVTGVLSGINMSGDLRAPSTDIPNGTLAAFGTSTFLYLVFVLFLGATCQRSFL 348
              :..:|.:.|..|||:::|.||||:|..||..||.||:.|...:.|:|::....:..|..|..|
Worm   318 TDFALMFAIIFSGVTGLMAGANMSGELARPSVSIPRGTVQAVFMTLFVYVMTAFLMATTSSRYLL 382

  Fly   349 YTDYMISVKVSAVHFLLLAGIYVSSMSSCLGAMYGTPRVLQSIAKESVIPGIDILGKGRGPNKV- 412
            ..||.:.:..:.....:|.||:.:::.|.:..:.|:.|||..::.:.      :.|....|.|:
Worm   383 QNDYTVMMDTNFHRVFILIGIFSTTLFSSMSNLIGSSRVLNRLSHDK------LFGCLLRPAKIE 441

  Fly   413 -----PLYAMAIVALVTVTFIIVGDINFLAPIVTMPFLLTYACIDYAYFALAQTFDIQEQREERF 472
                 |:.::.|..:..|...:||.:|.:|.:.::.|||:|..::.|..||..|
Worm   442 IGDRNPVVSVVITWMCVVLVFLVGAMNKIAKLTSIFFLLSYMGVNVATLALELT----------- 495

  Fly   473 RIQASSPSYE-TRRYGS 488
                |:|::. |.:|.|
Worm   496 ----SAPNFRPTFKYFS 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12773	NP_001284773.1	2a30	88..>456	CDD:273347	112/416 (27%)
T04B8.5	NP_001022305.1	2a30	85..943	CDD:273347	119/445 (27%)
T04B8.5	NP_001022305.1	SLC12	593..943	CDD:281515
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910