Protein Alignment CG12773 and Slc12a8

DIOPT Version :10

• Sequence 1: NP_569905.1
• Gene: CG12773 / 31082
• FlyBaseID: FBgn0024365
• Length: 712
• Species: Drosophila melanogaster
• Sequence 2: NP_599012.2
• Gene: Slc12a8 / 171286
• MGIID: 2443672
• Length: 705
• Species: Mus musculus
• Alignment Length: 704
• Identity: 282/704 - (40%)
• Similarity: 408/704 - (57%)
• Gaps: 82/704 - (11%)

  Fly    68 EIF--AGEQG----DKPWWRSNFFISQPVLFGTWDGVFTSCLINVFGVIVFLRSGWIVAQAGILN 126
            |:|  |.:||    .:|||:...|:.:||||||||||||||:||:|||::|||:||:|...|:|.
Mouse     8 ELFHEAAQQGILAQPQPWWKIQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLL 72

  Fly   127 AVLIIFCTVVIALVSVLSAIGICERCRVESGGVYFLIAHTLGSRFGGALGLLYCFGQAVGCALNV 191
            .:|::...|::||::|||.||:.|...:.|||||.:|:..||.:.||.:||||.|||.|..|:.:
Mouse    73 GLLLVSFVVLVALITVLSGIGVAEHGGISSGGVYSMISSVLGGQMGGTVGLLYVFGQCVAGAMYI 137

  Fly   192 MGFGESMAGLVGLEGSKWAIRGFATAAVLLLGCINVAGVKWVIKLQFILLMILLISALDFMVGSF 256
            .||.||::.|:|| |..||:||.:.|.:|.|..||:|||||:|:||.:||::|.:|.|||:||||
Mouse   138 TGFAESISDLLGL-GDIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLLLLAVSTLDFVVGSF 201

  Fly   257 TS-EASGGFNGWASGNFVENLWPKYDDGYSWFRVFGVFFPTVTGVLSGINMSGDLRAPSTDIPNG 320
            |. :...||.|::......|:.|:|..|.|:|.|||||||..|||::|.||.||||.|:..:|.|
Mouse   202 THLDPEHGFIGYSPELLQSNILPEYSPGESFFTVFGVFFPAATGVMAGFNMGGDLRDPADSVPLG 266

  Fly   321 TLAAFGTSTFLYLVFVLFLGATCQRSFLYTDYMISVKVSAVHFLLLAGIYVSSMSSCLGAMYGTP 385
            :|||.|.|.|||::|...|||.|.|..|.:|::|:.|||.|.||.|.|:|:||::||:|.:||.|
Mouse   267 SLAAVGVSWFLYIIFAFLLGAVCTREALRSDFLIAEKVSLVGFLFLLGLYISSLASCMGGLYGAP 331

  Fly   386 RVLQSIAKESVIPGIDILGKGRGPNKVPLYAMAIVALVTVTFIIVGDINFLAPIVTMPFLLTYAC 450
            |:||.||::.|||.:..|..|:||||.|:.|:.:.:|||:.|::||.:|.|||:||:.|:|||..
Mouse   332 RILQCIAQDKVIPALAFLANGKGPNKTPVAAICLTSLVTMAFVLVGQVNVLAPVVTINFMLTYIM 396

  Fly   451 IDYAYFALAQTF--------DIQEQREERFR-----IQASSPSY------ETRRYGSVSDTGNDL 496
            :||:||||:...        .:..|..:...     :|..:|||      .:...|::.:...|:
Mouse   397 VDYSYFALSMAHCGLAPSPEPVPRQGPDTLHCSEHLLQDRAPSYGSDVPARSLSEGTLLEFTKDM 461

  Fly   497 D-LLFP-DRVRHKNLQSPQ-NSPLHQT--------------------VPLEFDNE---------- 528
            | .|.| :.:..:.|.|.: |:|.:|.                    .||.|...
Mouse   462 DQFLQPIEELESRQLGSREGNNPKNQKRKGKKGAKQTLQDSFLLDPGSPLSFPTRTSERLSVAFC 526

  Fly   529 GPSTSNQAQSSERRTGHEADTTLAVEQAVAQAGVEQD--------QGDEAEPIAPIRPPIHSKTK 585
            |...|.|.|.:.|...|:.    .|.....|..|.::        |..|.:.    ||.:
Mouse   527 GEQESYQKQQTSRSESHDH----LVPDLRNQPRVNREDFFLKCRLQEQEIQR----RPSV----- 578

  Fly   586 NWYSGYCNRWASLLGAFTKLLVMLLVNWYYALTCFLVVFVVWFYVGTANPAVKPGLTAEFNFFAW 650
             :|:..||.|.|||||...||:|.::.|.|.|....|..:|:||:|.|:|.:..|..:.|:||.|
Mouse   579 -FYACMCNPWVSLLGALASLLIMFVIQWLYTLASMGVAALVYFYIGQASPGLYLGSASNFSFFQW 642

  Fly   651 LKSVIFRCFGKRMNEYEQIVVTPSCPGVDLSPTQLNEQNEDFRPRPNYHHSSVI 704
            :||.:........:..|||::.||...||::.|||.:.|.||..|..|||||.:
Mouse   643 MKSFLVPSCRSLRSAQEQIILAPSPAKVDMAMTQLTQDNADFATRDRYHHSSFL 696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12773	NP_569905.1	AA_permease_2	88..>456	CDD:459263	190/368 (52%)
Slc12a8	NP_599012.2	AA_permease_2	34..>420	CDD:459263	194/386 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	472..512		6/39 (15%)