Protein Alignment CG12773 and Slc12a8

DIOPT Version :9

• Sequence 1: NP_001284773.1
• Gene: CG12773 / 31082
• FlyBaseID: FBgn0024365
• Length: 712
• Species: Drosophila melanogaster
• Sequence 2: NP_001357928.1
• Gene: Slc12a8 / 171286
• MGIID: 2443672
• Length: 705
• Species: Mus musculus
• Alignment Length: 704
• Identity: 282/704 - (40%)
• Similarity: 408/704 - (57%)
• Gaps: 82/704 - (11%)

  Fly    68 EIF--AGEQG----DKPWWRSNFFISQPVLFGTWDGVFTSCLINVFGVIVFLRSGWIVAQAGILN 126
            |:|  |.:||    .:|||:...|:.:||||||||||||||:||:|||::|||:||:|...|:|.
Mouse     8 ELFHEAAQQGILAQPQPWWKIQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLL 72

  Fly   127 AVLIIFCTVVIALVSVLSAIGICERCRVESGGVYFLIAHTLGSRFGGALGLLYCFGQAVGCALNV 191
            .:|::...|::||::|||.||:.|...:.|||||.:|:..||.:.||.:||||.|||.|..|:.:
Mouse    73 GLLLVSFVVLVALITVLSGIGVAEHGGISSGGVYSMISSVLGGQMGGTVGLLYVFGQCVAGAMYI 137

  Fly   192 MGFGESMAGLVGLEGSKWAIRGFATAAVLLLGCINVAGVKWVIKLQFILLMILLISALDFMVGSF 256
            .||.||::.|:|| |..||:||.:.|.:|.|..||:|||||:|:||.:||::|.:|.|||:||||
Mouse   138 TGFAESISDLLGL-GDIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLLLLAVSTLDFVVGSF 201

  Fly   257 TS-EASGGFNGWASGNFVENLWPKYDDGYSWFRVFGVFFPTVTGVLSGINMSGDLRAPSTDIPNG 320
            |. :...||.|::......|:.|:|..|.|:|.|||||||..|||::|.||.||||.|:..:|.|
Mouse   202 THLDPEHGFIGYSPELLQSNILPEYSPGESFFTVFGVFFPAATGVMAGFNMGGDLRDPADSVPLG 266

  Fly   321 TLAAFGTSTFLYLVFVLFLGATCQRSFLYTDYMISVKVSAVHFLLLAGIYVSSMSSCLGAMYGTP 385
            :|||.|.|.|||::|...|||.|.|..|.:|::|:.|||.|.||.|.|:|:||::||:|.:||.|
Mouse   267 SLAAVGVSWFLYIIFAFLLGAVCTREALRSDFLIAEKVSLVGFLFLLGLYISSLASCMGGLYGAP 331

  Fly   386 RVLQSIAKESVIPGIDILGKGRGPNKVPLYAMAIVALVTVTFIIVGDINFLAPIVTMPFLLTYAC 450
            |:||.||::.|||.:..|..|:||||.|:.|:.:.:|||:.|::||.:|.|||:||:.|:|||..
Mouse   332 RILQCIAQDKVIPALAFLANGKGPNKTPVAAICLTSLVTMAFVLVGQVNVLAPVVTINFMLTYIM 396

  Fly   451 IDYAYFALAQTF--------DIQEQREERFR-----IQASSPSY------ETRRYGSVSDTGNDL 496
            :||:||||:...        .:..|..:...     :|..:|||      .:...|::.:...|:
Mouse   397 VDYSYFALSMAHCGLAPSPEPVPRQGPDTLHCSEHLLQDRAPSYGSDVPARSLSEGTLLEFTKDM 461

  Fly   497 D-LLFP-DRVRHKNLQSPQ-NSPLHQT--------------------VPLEFDNE---------- 528
            | .|.| :.:..:.|.|.: |:|.:|.                    .||.|...
Mouse   462 DQFLQPIEELESRQLGSREGNNPKNQKRKGKKGAKQTLQDSFLLDPGSPLSFPTRTSERLSVAFC 526

  Fly   529 GPSTSNQAQSSERRTGHEADTTLAVEQAVAQAGVEQD--------QGDEAEPIAPIRPPIHSKTK 585
            |...|.|.|.:.|...|:.    .|.....|..|.::        |..|.:.    ||.:
Mouse   527 GEQESYQKQQTSRSESHDH----LVPDLRNQPRVNREDFFLKCRLQEQEIQR----RPSV----- 578

  Fly   586 NWYSGYCNRWASLLGAFTKLLVMLLVNWYYALTCFLVVFVVWFYVGTANPAVKPGLTAEFNFFAW 650
             :|:..||.|.|||||...||:|.::.|.|.|....|..:|:||:|.|:|.:..|..:.|:||.|
Mouse   579 -FYACMCNPWVSLLGALASLLIMFVIQWLYTLASMGVAALVYFYIGQASPGLYLGSASNFSFFQW 642

  Fly   651 LKSVIFRCFGKRMNEYEQIVVTPSCPGVDLSPTQLNEQNEDFRPRPNYHHSSVI 704
            :||.:........:..|||::.||...||::.|||.:.|.||..|..|||||.:
Mouse   643 MKSFLVPSCRSLRSAQEQIILAPSPAKVDMAMTQLTQDNADFATRDRYHHSSFL 696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12773	NP_001284773.1	2a30	88..>456	CDD:273347	190/368 (52%)
Slc12a8	NP_001357928.1	2a30	34..>420	CDD:273347	194/386 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	472..512		6/39 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835677
Domainoid	1	1.000	392	1.000	Domainoid score	I774
eggNOG	1	0.900	-	-		E2759_KOG2083
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11628
Inparanoid	1	1.050	505	1.000	Inparanoid score	I1331
Isobase	1	0.950	-	0.946395	Normalized mean entropy	S3116
OMA	1	1.010	-	-		QHG48035
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007328
OrthoInspector	1	1.000	-	-		oto94965
orthoMCL	1	0.900	-	-		OOG6_108582
Panther	1	1.100	-	-	LDO	PTHR11827
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3761
SonicParanoid	1	1.000	-	-		X5443
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740