DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MTPAP and Tut1

DIOPT Version :9

Sequence 1:	NP_001259129.1	Gene:	MTPAP / 31081	FlyBaseID:	FBgn0024360	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_932110.1	Gene:	Tut1 / 70044	MGIID:	1917294	Length:	869	Species:	Mus musculus

Alignment Length:	735	Identity:	180/735 - (24%)
Similarity:	276/735 - (37%)	Gaps:	224/735 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RTYCIKHNASEAASPGRNA---GRPNYEEFIGRHQRQAQCSIVVQVSS---EKSYEELYNYCSSF 74
            |..|...:.:.|..|..:|   ||.:.:....|..|:||....|.||.   :....:|..|..:|
Mouse    15 RFRCCLCDVTTANRPSLDAHLKGRKHRDLVQLRATRKAQGLRSVFVSGFPRDVGSAQLSEYFQTF 79

  Fly    75 GSIMGAHHYCVRQDETLHYILLEYATSDEAAAAIGAGVTNGELS----------------GVPVR 123
            |.:..              |:::   .|:...||   |..|::|                |:.||
Mouse    80 GPVAN--------------IVMD---KDKGVFAI---VEMGDISAREAVLSQPKHSLGGHGLRVR 124

  Fly   124 --------SPFLWFRAAGGGRRSPKLVANTAPALLSLDGTRQVDQRHLLGLLRGAADIEEQVQQL 180
                    ||         ..:|||.|.:::              ..|:..|..|||:..|:.:|
Mouse   125 PREQKEFQSP---------ASKSPKGVDSSS--------------HQLVQALAEAADVGAQMVKL 166

  Fly   181 YEHTRLNELGIRMRFLAALQVQQAIAGMFPAAQAQPFGSSVNGFGRMGCDLDLILRFDSDMG--- 242
            .|...|:|...::|.|....:|:.....||.....||||:||.|...||||||.|    |||
Mouse   167 VELRELSEAERQLRNLVVALMQEVFTEFFPGCVVHPFGSTVNSFDVHGCDLDLFL----DMGDME 227

  Fly   243 --------AKIP----LEAAV-----------------------------------PSRLVYHTK 260
                    .|:|    |::|:                                   ||.|...|.
Mouse   228 ETEPDPKAPKVPETSSLDSALASSLDPQALACTPASPLDSLSPTSVQESESLDFDTPSSLAPQTP 292

  Fly   261 EN---------------------------------LSNGRSQTQRH-----MECFGDMLHLFLPG 287
            ::                                 |:...|:.::.     :|..|.:|...:||
Mouse   293 DSALGSDTVTSPQSLPPVSPLQEDRKEGKQGKELELAEEASKDEKEEAAAVLELVGSILRGCVPG 357

  Fly   288 VCHVRRILQARVPIIKYHHEHLDLEVDLSMSNLTGFYMSELLYMFGEMDPRVRPLTFTIRRWAQT 352
            |..|:.:..||.|::|:.|....|..|:|:||....|.|..|.:..|||.|||||.:|:|.|||.
Mouse   358 VYRVQTVPSARRPVVKFCHRPSGLHGDVSLSNRLALYNSRFLNLCSEMDGRVRPLVYTLRCWAQH 422

  Fly   353 CGLTNPSPGRWISNFSLTCLVMFFLQQLRQPILPTIGALAKAAEPGDSRVTEDGINCTFTRNVDR 417
            .||:...|  .::|::||.||::|||....|:|||:..|.:.|..|: :|..||.:|:|.::..|
Mouse   423 NGLSGGGP--LLNNYALTLLVIYFLQTRDPPVLPTVAQLTQRAGEGE-QVEVDGWDCSFPKDASR 484

  Fly   418 LGFRSRNQSSLSELLLQFFEFYSQFDFHNRAISLNEGKPLSKPDH-----------SAMYIVNPL 471
            |. .|.|...||.||.|||...|..|.....:||.||:||...:.           ..|.:.:|.
Mouse   485 LE-PSTNVEPLSSLLAQFFSCVSCLDLSGSLLSLREGRPLMVAEGLPSDLWEGLRLGPMNLQDPF 548

  Fly   472 EQLLNVSKNVSLEECERLRIEVRNAAWVLESEVENASVPEGDGQELSCGLLNLFKHPEKAVIRPN 536
            :...||:.||:....:||    ::......|...:....:...:....|||.|.: |..    |:
Mouse   549 DLSHNVAANVTGRVAKRL----QSCCGAAASYCRSLQYQQRSSRGRDWGLLPLLQ-PSS----PS 604

  Fly   537 MFFKPRMVEVSDLFEQKEAGATSSSTPPTPAITYKSASVRQQVQSIKAATRSEL--------KQL 593
            .....:::                   |.|     ||...|.:.::....|..|        |:.
Mouse   605 SLLSAKLI-------------------PLP-----SAPFPQVIMALVDVLREALGCHIEQGTKRR 645

  Fly   594 RGSGSSV---PTSSPNNRRR 610
            |..|:.:   |....|.|:|
Mouse   646 RSEGARIKDSPLGGVNKRQR 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MTPAP	NP_001259129.1	NT_PAP_TUTase	193..333	CDD:143392	52/227 (23%)
MTPAP	NP_001259129.1	PAP_assoc	427..477	CDD:281779	17/60 (28%)
Tut1	NP_932110.1	ZnF_U1	14..47	CDD:197732	7/31 (23%)
		RRM_TUT1	54..127	CDD:240725	17/92 (18%)
		RRM	<56..>140	CDD:223796	20/112 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	114..144		9/38 (24%)
		NT_PAP_TUTase	179..403	CDD:143392	52/227 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..247		3/20 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..335		6/75 (8%)
		KA1, binds the bulging loops of U6 snRNA but is dispensable for terminal uridylyltransferase activity. /evidence=ECO:0000250\|UniProtKB:Q9H6E5	601..869		15/93 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	640..689		7/26 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	735..757
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	775..796
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	803..822
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5260
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1188122at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12271
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920