DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MTPAP and Mtpap

DIOPT Version :9

Sequence 1:	NP_001259129.1	Gene:	MTPAP / 31081	FlyBaseID:	FBgn0024360	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_080433.1	Gene:	Mtpap / 67440	MGIID:	1914690	Length:	585	Species:	Mus musculus

Alignment Length:	587	Identity:	177/587 - (30%)
Similarity:	291/587 - (49%)	Gaps:	59/587 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NSLVRRSAQQLSLWRTYCIKHNASEAASPGRNAG------RPNYEEFIGRHQRQAQCSIVVQVSS 60
            |.:.|..::.||...|......:.|.:|.....|      :..:.|.....:.|||.::::...:
Mouse    20 NRIPRSISRLLSCPGTIAASIGSEEQSSVVAETGIEDKTLQKKFSEVQKERREQAQRTVLIHCPN 84

  Fly    61 EKSYEELYNYCSSFGSIMGAHHYCVRQDETLH-YILLEYATSDEAAAAIGAGV---TNGELSGVP 121
            ..:.::...|.|..|.:.....|     |:.. :.::|:...| :..::..|.   |....:.:|
Mouse    85 NINEKKFLKYLSQHGPVNNHFFY-----ESFGLFAVVEFCQKD-SIKSLQNGTHTPTQSTEAAIP 143

  Fly   122 VRSPFLWFRAAGGGRRSPKLVANTAPALLSLDGTRQ--VDQRHLLGLLRGAADIEEQVQQLYEHT 184
            .:|.||..|.     ::|....:..|.:.:   |.|  ...:.|..||..|..||||:..|.:..
Mouse   144 FKSRFLNLRL-----KNPSSQVSGQPFVQT---TNQSPPSSKKLFELLSYAESIEEQLNTLLKAF 200

  Fly   185 RLNELGIRMRFLAALQVQQAIAGMFPAAQAQPFGSSVNGFGRMGCDLDLILRFDSDMGAKIPLEA 249
            :|.|..||:|.|....::...|..||:...:|||||||.||::|||||:.|  |.|...|:.:..
Mouse   201 QLTEENIRLRHLTCSLIEDIAAAYFPSCVIRPFGSSVNTFGKLGCDLDMFL--DLDETGKLDVHK 263

  Fly   250 AVPSRLVYHTKENLSNGRSQTQRHMECFGDMLHLFLPGVCHVRRILQARVPIIKYHHEHLDLEVD 314
            ...:..:....:|:.:.|..||:.:...|:.|..|.||...|::||.||.|::::.|:....:.|
Mouse   264 NTGNFFMEFQVKNVPSERIATQKILSVIGECLDNFGPGCVGVQKILNARCPLVRFSHQGSGFQCD 328

  Fly   315 LSMSNLTGFYMSELLYMFGEMDPRVRPLTFTIRRWAQTCGLTNPSPGRWISNFSLTCLVMFFLQQ 379
            |:.:|......|||||::|.:|.|||.|.|::|.||:...||:..||.||:|||||.:|:||||:
Mouse   329 LTANNSIALKSSELLYIYGSLDSRVRALVFSVRCWARAHSLTSSIPGAWITNFSLTVMVIFFLQR 393

  Fly   380 LRQPILPTIGALAKAAEPGDSRVTEDGINCTFTRNVDRLGFRSRNQSSLSELLLQFFEFYSQFDF 444
            ...|||||:.:|...|:..|..:.| |.||||.::|:::. .|.|..:|..|:.:|||::..|.|
Mouse   394 RSPPILPTLDSLKSIADAEDRCILE-GNNCTFVQDVNKIQ-PSGNTETLELLIKEFFEYFGNFAF 456

  Fly   445 HNRAISLNEGKPLSKPDHSAMYIVNPLEQLLNVSKNVSLEECERLRIEVRNAAWVLESEVENAS- 508
            :..:|::.:|:..:|||.|.:||.||.|..||:|||||..:.::.....|::||:||.|.:|..
Mouse   457 NKNSINIRQGREQNKPDSSPLYIQNPFETSLNISKNVSQSQLQKFVELARDSAWILEQEDKNQPF 521

  Fly   509 -------------VPEGDGQELSCGLLNLFKHPEKAVIRPNMFFKPRMVEVSDLFEQKEAGATSS 560
                         :|.|.|.      .:|.:..:|         ||...:|..|....::.:..|
Mouse   522 SSSRQPWGLAALLLPPGSGH------TSLSRKKKK---------KPMSEKVKGLLASIKSNSPDS 571

  Fly   561 ST 562
            ||
Mouse   572 ST 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MTPAP	NP_001259129.1	NT_PAP_TUTase	193..333	CDD:143392	47/139 (34%)
MTPAP	NP_001259129.1	PAP_assoc	427..477	CDD:281779	19/49 (39%)
Mtpap	NP_080433.1	NT_PAP_TUTase	209..347	CDD:143392	47/139 (34%)
		PAP_assoc	441..486	CDD:281779	17/44 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..585		11/52 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842830
Domainoid	1	1.000	188	1.000	Domainoid score	I3319
eggNOG	1	0.900	-	-		E1_COG5260
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10008
Inparanoid	1	1.050	257	1.000	Inparanoid score	I3136
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47599
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007101
OrthoInspector	1	1.000	-	-		oto92700
orthoMCL	1	0.900	-	-		OOG6_108916
Panther	1	1.100	-	-	LDO	PTHR12271
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5151
SonicParanoid	1	1.000	-	-		X3421
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790