DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MTPAP and tent4b

DIOPT Version :9

Sequence 1:	NP_001259129.1	Gene:	MTPAP / 31081	FlyBaseID:	FBgn0024360	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_001313625.1	Gene:	tent4b / 568678	ZFINID:	ZDB-GENE-041021-2	Length:	653	Species:	Danio rerio

Alignment Length:	702	Identity:	123/702 - (17%)
Similarity:	232/702 - (33%)	Gaps:	241/702 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 NASEAASPGRNAGRPNYEEFIGRHQRQAQCSIVVQVSSEKSYEELYNYCSSFGSIMGAHHYCVRQ 87
            ||::::|     |||..::.:...:..:      :||.::.:..|    .:|.:|
Zfish    56 NAADSSS-----GRPKDQQGMSGSKPDS------EVSEQQDFIPL----EAFNNI---------- 95

  Fly    88 DETLHYILLEYATSDEAAAAIGAGVTNGELSGVPVRSPFLWFRAAGGGRRSP--KLVANTAP--- 147
                        .|......:|.|   |::.|..|         ||.|...|  :...|.|.
Zfish    96 ------------NSSRPGRVVGGG---GQVGGSGV---------AGVGNELPSKRKRDNKASTYG 136

  Fly   148 ---ALLSLDG-----------TRQVDQRHLLGLLRGAADIEEQVQQLYEHTRLNELGIRMRFLAA 198
               :||..||           :|....        |...:.|:::..||:........:||....
Zfish   137 FNRSLLLTDGAEDGYAGTPWKSRNYSD--------GIVGLHEEIKDFYEYISPRPEEEQMRHEVV 193

  Fly   199 LQVQQAIAGMFPAAQAQPFGSSVNGFGRMGCDLDLILRFDSDMGAKIPLEAAVPSRLVYHTKENL 263
            .::|:.|..::|.|:...|||...|......|:||::..:.:......||.|:..|.|  ..||
Zfish   194 ARIQRVIKDLWPNAEVCVFGSFSTGLYLPTSDIDLVVFGNWETLPLWTLEEALRKRKV--ADEN- 255

  Fly   264 SNGRSQTQRHMECFGDMLHLFLPGVCHVRRILQARVPIIKYHHEHLDLEVDLSMSNLTGFYMSEL 328
                                      .::.:.:|.|||||....|.:::||:|.:..:|...:.|
Zfish   256 --------------------------SIKVLDKATVPIIKLMDSHTEVKVDISFNVQSGVKAANL 294

  Fly   329 LYMFGEMDPRVRPLTFTIRRWAQTCGLTNPSPGRWISNFSLTCLVMFFLQ-QLRQPILPTIGALA 392
            :..:.:..|.:..|...::::.....|.....| .|.::||..:.:.||| ..|:.:
Zfish   295 IKDYKQQYPVLPYLVLVLKQFLLQRELNEVFTG-GIGSYSLFLMAVSFLQLHCREDV-------- 350

  Fly   393 KAAEPGDSRVTEDGINCTFTRNVDRLGFRSRNQSSLSELLLQFFEFYSQ-FDFHNRAISLNEGKP 456
                                         |.:..:|..||::|||.|.: |::....|.:.:|..
Zfish   351 -----------------------------SSSNPNLGVLLIEFFELYGRHFNYLKTGIRIKDGGS 386

  Fly   457 LSKPDH-----------SAMYIVNPLEQLLNVSKNVSLEECERLRI-EVRNAAWVLESEVENASV 509
            ....|.           |.:||.:||:.    ..:|.......::: |..:.|:|:.|...:...
Zfish   387 YVAKDEVQKSMLDGYRPSMLYIEDPLQP----GNDVGRSSYGAMQVKEAFDYAYVILSHAVSPIA 447

  Fly   510 ---PEGDGQELSCGLLNLF----------------KHPEKAVIRPNMFFKPRMVEVSDLFE---- 551
               |....:.:...::.:.                |..::.|:..|......:||..:|.|
Zfish   448 KYYPNNKSESILGRIIRVTQEVVEYRDWISAQWGQKSSKEPVLNCNANDLTLLVEREELDECNNN 512

  Fly   552 -------------QKEAGATSSSTPPTPA-----------------------ITYKSASV----- 575
                         .|.:..:||.:|.:|:                       ..||:|..
Zfish   513 LSEDSVVCTSVPRSKVSSNSSSPSPSSPSSPSSSSSSPSSTASSSSDADSDGTPYKTAKALGGRS 577

  Fly   576 ------------RQQVQSIKAAT----RSELKQLRGSGSSVPTSSPNNRRRS 611
                        |.|..|...:|    .::.:||....:..|.::||..::|
Zfish   578 TYSENTERISNHRSQNHSASISTPTHKGNKSRQLANKSTQGPHNNPNKIQQS 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MTPAP	NP_001259129.1	NT_PAP_TUTase	193..333	CDD:143392	32/139 (23%)
MTPAP	NP_001259129.1	PAP_assoc	427..477	CDD:281779	16/61 (26%)
tent4b	NP_001313625.1	NT_PAP_TUTase	188..298	CDD:143392	32/138 (23%)
tent4b	NP_001313625.1	PAP_assoc	356..416	CDD:281779	16/63 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5260
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810