Protein Alignment MTPAP and Tut1

DIOPT Version :10

• Sequence 1: NP_569904.1
• Gene: MTPAP / 31081
• FlyBaseID: FBgn0024360
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_001029073.1
• Gene: Tut1 / 499314
• RGDID: 1561043
• Length: 866
• Species: Rattus norvegicus
• Alignment Length: 711
• Identity: 176/711 - (24%)
• Similarity: 269/711 - (37%)
• Gaps: 178/711 - (25%)

  Fly    16 RTYCIKHNASEAASPGRNA---GRPNYEEFIGRHQRQAQCSIVVQVSS---EKSYEELYNYCSSF 74
            |..|...:.:.|..|..:|   ||.:.:....|..|:||....|.||.   :....:|..|..:|
  Rat    15 RFRCCLCDVTTANRPSLDAHLKGRKHRDLVQLRATRKAQGLRSVFVSGFPRDVGSAQLSEYFQTF 79

  Fly    75 GSIMGAHHYCVRQDETLHYILLEYATSDEAAAAIGAGVTNGELSGVPVRSPFLWFRAAGGGRRSP 139
            |.:..              |:::   .|:...||   |..|::|.          |.|...:...
  Rat    80 GPVAN--------------IVMD---KDKGVFAI---VEMGDISA----------REAVLSQPKH 114

  Fly   140 KLVANT------------APALLSLDGTRQVDQRHLLGLLRGAADIEEQVQQLYEHTRLNELGIR 192
            .|..:|            :||..|..|. ..:...|...|..|||:..|:.:|.|...|:|...:
  Rat   115 SLGGHTLRVRPREQKEFQSPASKSPKGV-DSNSHQLAQALAEAADVGAQMVKLVELRELSEAERQ 178

  Fly   193 MRFLAALQVQQAIAGMFPAAQAQPFGSSVNGFGRMGCDLDLILRFDSDMG-----------AKIP 246
            :|.|....:|:.....||.....|||||||.|...||||||.|    |:|           .|:|
  Rat   179 LRTLVVALMQEVFTEFFPGCVVHPFGSSVNSFDVHGCDLDLFL----DLGDMEEPQPDPQTPKLP 239

  Fly   247 --------------------------------------LEAAVPSRLVYHT-------------- 259
                                                  |:...||.|...|
  Rat   240 EASSLDSTLASSLDPQVLACTPASLDSLSPTSLQDSEALDFETPSSLAPQTPDSALGSDTVTSPQ 304

  Fly   260 --------KENLSNGRSQTQRH---------------MECFGDMLHLFLPGVCHVRRILQARVPI 301
                    :|:...|:.:.:..               :|..|.:|...:|||..|:.:..||.|:
  Rat   305 SLPPVSPLEEDRGEGKHRKELELAEASKDEKEEATAVLELVGSILRGCVPGVYRVQTVPSARRPV 369

  Fly   302 IKYHHEHLDLEVDLSMSNLTGFYMSELLYMFGEMDPRVRPLTFTIRRWAQTCGLTNPSPGRWISN 366
            :|:.|....|..|:|:||....|.|..|.:..|||.|||||.:|:|.|||..||:...|  .::|
  Rat   370 VKFCHRPSGLHGDISLSNRLALYNSRFLNLCSEMDSRVRPLVYTLRCWAQHNGLSGGGP--LLNN 432

  Fly   367 FSLTCLVMFFLQQLRQPILPTIGALAKAAEPGDSRVTEDGINCTFTRNVDRLGFRSRNQSSLSEL 431
            ::||.||::|||....|:|||:..|.:.:..|: :|..||.:|:|.::..||. .|.|...||.|
  Rat   433 YALTLLVIYFLQTRDPPVLPTVAQLTQRSGEGE-QVEVDGWDCSFPKDASRLE-PSTNVEPLSSL 495

  Fly   432 LLQFFEFYSQFDFHNRAISLNEGKPL----SKPDH-------SAMYIVNPLEQLLNVSKNVSLEE 485
            |.|||...|.:|.....:||.||:.|    ..|..       ..|.:.:|.:...||:.||:...
  Rat   496 LAQFFSCVSCWDLSGSLLSLREGQALMVAGGLPSDLWEGLRLGPMNLQDPFDLSHNVAANVTSRV 560

  Fly   486 CERLRIEVRNAAWVLESEVENASVPEGDGQELSCGLLNLFKHPEKAVIRPNMFFKPRMVEVSDLF 550
            .:||:.....||    |...:....:...:....|||.|.: |..    |:.....:::.:
  Rat   561 AKRLQSSCGAAA----SYCRSLQYQQRSSRGRDWGLLPLLQ-PSS----PSSLLSAKLIPL---- 612

  Fly   551 EQKEAGATSSSTPPTPAITYKSASVRQQVQSIKAATRSELKQLRGSGS-SVPTSSPNNRRR 610
                      .:.|.|.|.....||.::.........::.::..|:.| ..|....|.|.|
  Rat   613 ----------PSAPFPQIITALVSVLREALGCHIEQGTKRRRSEGARSKDSPLGGANKRPR 663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MTPAP	NP_569904.1	NT_PAP_TUTase	193..333	CDD:143392	51/225 (23%)
		PAP_assoc	427..>461	CDD:427532	14/37 (38%)
Tut1	NP_001029073.1	zf-met	16..40	CDD:463736	6/23 (26%)
		RRM_TUT1	54..127	CDD:409721	18/102 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..147		6/31 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	223..249		3/25 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	267..321		7/53 (13%)
		NT_PAP_TUTase	<331..401	CDD:143392	20/69 (29%)
		TRF4	<358..>566	CDD:227585	76/211 (36%)
		KA1, binds the bulging loops of U6 snRNA but is dispensable for terminal uridylyltransferase activity. /evidence=ECO:0000250|UniProtKB:Q9H6E5	599..866		12/83 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	638..687		6/26 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	728..755
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	773..792