DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MTPAP and cid11

DIOPT Version :9

Sequence 1:	NP_001259129.1	Gene:	MTPAP / 31081	FlyBaseID:	FBgn0024360	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_595210.1	Gene:	cid11 / 2539762	PomBaseID:	SPBC1685.06	Length:	478	Species:	Schizosaccharomyces pombe

Alignment Length:	468	Identity:	106/468 - (22%)
Similarity:	191/468 - (40%)	Gaps:	133/468 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 ADIEEQVQQLY--------EHTRLNELGIRMRFLAALQVQQAIAGMFPAAQAQPFGSSVNGFGRM 227
            |::..:..:||        |.:|..:...::|.:.:.:::.|...:|      .|||:.|.....
pombe    45 AELTNECWKLYMRLKPSNEEVSRRQQFVDKLRTILSTEIKDAKLDLF------VFGSTENNLAIQ 103

  Fly   228 GCDLDLILRFDSDMGAKIPLEAAVPSRLVYHTKENLSNGRSQTQRHMECFGDMLHLFLPGVCHVR 292
            ..|:|:.:..:   |:|........::|:|      |.|..|.                 ||
pombe   104 QSDVDVCIITN---GSKYLNSTCQLAQLLY------SYGMKQI-----------------VC--- 139

  Fly   293 RILQARVPIIKYHHEHLDLEVDLSMSNLTGFYMSELLYMFGEMDPRVRPLTFTIRRWAQTCGLTN 357
             :.:|||||:|......|:..||:::|......:::|.:|..:|||||||...|:.||:...|.:
pombe   140 -VSRARVPIVKIWDPQFDIHCDLNINNDVAKINTKMLRLFVSIDPRVRPLGLIIKYWAKQRALCD 203

  Fly   358 PSPGRWISNFSLTCLVMFFLQQLRQPILPTIGALAKAAEPGDSRVTEDGINCTFTRNVDRLGFRS 422
            .:....|::::::|:::.|||....||||   |:.......|:::..|          |.:||:.
pombe   204 AAGSGTITSYTISCMLVNFLQTRNPPILP---AMLDLMSNDDNKMFVD----------DIVGFKE 255

  Fly   423 R---NQSSLSELLLQFFEFYS-QFDFHNRAISLNEGKPLSKPDHS-AMYIVNPL--EQLLNVSKN 480
            :   |::||..||:.||.:|. .|::.:..:|:..|..|:|.:.. ||.:.|.|  |:..|.::|
pombe   256 KATLNKTSLGRLLIDFFYYYGFSFNYLDSVVSVRSGTVLNKQEKGWAMEVNNSLCVEEPFNTARN 320

  Fly   481 VS---------------------LEE---CERL--------RIEVRNAAWVLESEVENASVPEGD 513
            ::                     :.|   ||||        .:::.|     |:...|.:.|...
pombe   321 LANTADNPSVKGLQSEFQRAFRLMSENNACERLCKICEEYQFLDITN-----EANYGNTNTPFNT 380

  Fly   514 GQE-LSCGLLNLFKHPEKAVIRPNMFFKPRMVEVSD-----------------LFEQK------- 553
            ..| ..|....|   ||.|.. |..::.|: :.:||                 .:|.|
pombe   381 AYESFGCNHTVL---PEAAAY-PKPYYPPQ-ITLSDGGNMNFLYYIPDESNHQSYENKANRDSDF 440

  Fly   554 --EAGATSSSTPP 564
              :...|..|.||
pombe   441 QGQTSLTQGSAPP 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MTPAP	NP_001259129.1	NT_PAP_TUTase	193..333	CDD:143392	29/139 (21%)
MTPAP	NP_001259129.1	PAP_assoc	427..477	CDD:281779	17/53 (32%)
cid11	NP_595210.1	TRF4	1..478	CDD:227585	106/468 (23%)
		NT_PAP_TUTase	67..179	CDD:143392	30/147 (20%)
		PAP_assoc	263..317	CDD:281779	17/53 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5260
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12271
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870