DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MTPAP and Tut7

DIOPT Version :9

Sequence 1:	NP_001259129.1	Gene:	MTPAP / 31081	FlyBaseID:	FBgn0024360	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_001360893.1	Gene:	Tut7 / 214290	MGIID:	2387179	Length:	1534	Species:	Mus musculus

Alignment Length:	461	Identity:	108/461 - (23%)
Similarity:	183/461 - (39%)	Gaps:	106/461 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 IEEQVQQLYEHTRLNELGIRMRFLAALQVQQAIAGMFPAAQAQPFGSSVNGFGRMGCDLDLILRF 237
            :|:|.:   ||.|.|             ::..|...||..:...||||.||||....|||:.:..
Mouse  1013 VEDQAR---EHIRQN-------------LESFIKQDFPGTKLSLFGSSKNGFGFKQSDLDVCMTI 1061

  Fly   238 DSDMGAKIPLEAAVPSRLVYHTKENLSNGRSQTQRHMECFGDMLHLFL-----PGVCHVRRILQA 297
                                       ||. :|...::|...:..|..     .|:.::..|..|
Mouse  1062 ---------------------------NGH-ETAEGLDCVRTIEELARVLRKHSGLRNILPITTA 1098

  Fly   298 RVPIIKYHHEHLDLEVDLSMSNLTGFYMSELLYMFGEMDPRVRPLTFTIRRWAQTCGLTNPSPGR 362
            :|||:|:.|....||||:|:.|....:.:.||..:..:||||:.|.:|::.:.:.|.:.:.|.|.
Mouse  1099 KVPIVKFFHLRSGLEVDISLYNTLALHNTRLLSAYSAIDPRVKYLCYTMKVFTKMCDIGDASRGS 1163

  Fly   363 WISNFSLTCLVMFFLQQLRQPILPTIGALAKAAEPGDSRVTEDGINCTFTRNVDRLGF----RSR 423
             :|:::.|.:|::||||...|::|.:..:.|..:..:  :..||.|..|...::.|..    ..:
Mouse  1164 -LSSYAYTLMVLYFLQQRSPPVIPVLQEIYKGEKKPE--ILVDGWNIYFFDQINELPTCWPEYGK 1225

  Fly   424 NQSSLSELLLQFFEFYS-QFDFHNRAISLNEGKPLS--KPDHSAMYIV--NPLEQLLNVSKNVSL 483
            |...:.:|.|....||: :|||....||:.....|:  |...::.|||  :|.:...|:...:|.
Mouse  1226 NTEPVGQLWLGLLRFYTEEFDFKEHVISIRRKSLLTTFKKQWTSKYIVIEDPFDLNHNLGAGLSR 1290

  Fly   484 EECERLRIEVRNAAWVLESEV-----ENAS----------VPEGDGQELS--------CGLLNLF 525
            :....:.....|...|....|     :|.|          :.||   ||:        ||.:..|
Mouse  1291 KMTNFIMKAFINGRRVFGIPVKGFPKDNPSKLAYFFDPDVLTEG---ELAPNDRCCRICGKIGHF 1352

  Fly   526 KH--PEKAVIR--------PNMFFKPRM-------VEVSDLFEQKEAGATSSSTPPTPAITYKSA 573
            ..  |.:..:|        ||..:....       .|:.:.:.:||........  ||....|:.
Mouse  1353 MKDCPMRRKVRRRRDQEDTPNQRYSESKEKRSKEDKEIQNKYTEKEVSTKEDKL--TPCAAAKAK 1415

  Fly   574 SVRQQV 579
            .||..|
Mouse  1416 PVRAAV 1421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MTPAP	NP_001259129.1	NT_PAP_TUTase	193..333	CDD:143392	35/144 (24%)
MTPAP	NP_001259129.1	PAP_assoc	427..477	CDD:281779	15/54 (28%)
Tut7	NP_001360893.1	TUTase	205..539	CDD:408858
		PAP_assoc	550..599	CDD:397761
		2A1904	<673..>910	CDD:273344
		TRF4	975..>1306	CDD:227585	84/339 (25%)
		ZnF_C2HC	1342..1357	CDD:197667	3/14 (21%)
		TUTF7_u4	1365..1446	CDD:406924	11/59 (19%)
		ZnF_C2HC	1448..1464	CDD:197667
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5260
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810