DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MTPAP and cid-1

DIOPT Version :9

Sequence 1:	NP_001259129.1	Gene:	MTPAP / 31081	FlyBaseID:	FBgn0024360	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_498099.1	Gene:	cid-1 / 175707	WormBaseID:	WBGene00019629	Length:	1425	Species:	Caenorhabditis elegans

Alignment Length:	324	Identity:	78/324 - (24%)
Similarity:	147/324 - (45%)	Gaps:	41/324 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 DIEEQVQQLYEHTRLNELGIRMRFLAALQVQQAIAGMF-PAAQAQPFGSSVNGFGRMGCDLDLIL 235
            ||::.:.:.|....|:|..::|......::|..:...: .......|||.:.|......|:|:.|
Worm  1008 DIDDMIDKYYHENILDERRLKMLDHKIDELQSFLRKNYREDVTLTTFGSVMTGLSVNCSDIDICL 1072

  Fly   236 RF-DSDMGAKIPLEAAVPSRLVYHTKENLSNGRSQTQRHMECFGDMLHLFLPGVCHVRRILQARV 299
            || |.|    :|.:......::..|:..|          .:|     ||    |..|:.|:.|:|
Worm  1073 RFGDGD----VPPKDLTAKEVIQKTESVL----------RKC-----HL----VKRVQAIVTAKV 1114

  Fly   300 PIIKYHHEHLD---LEVDLSMSNLTGFYMSELL--YMFGEMDPRVRPLTFTIRRWAQTCGLTNPS 359
            ||:|:..:..:   ::||:|..|:...|.:.||  |.....|.|...|...::.||:.|.:.:.|
Worm  1115 PIVKFQVKLSNGAIIDVDISYYNILAIYNTALLKEYSLWTPDKRFAKLALFVKTWAKNCEIGDAS 1179

  Fly   360 PGRWISNFSLTCLVMFFLQQLRQPILPTIGALAKAAEPGDSRVTE--DGINCTFTRNVDRLGFR- 421
            .|. :|::....:::.:||....|:||.:....::    |:|...  |..:.:|.:....|..|
Worm  1180 RGS-LSSYCHVIMLISYLQNCDPPVLPRLQEDFRS----DNRERRLVDNWDTSFAQVETSLLQRW 1239

  Fly   422 SRNQSSLSELLLQFFEFYSQFDFHNRAISLNEGKPLSKPDHS---AMYIVNPLEQLLNVSKNVS 482
            .:|:.|.::||:.:|::||:|||.|..:.......|||.:..   .:.:.:|.:...|:|..|:
Worm  1240 PKNKESCAQLLIGYFDYYSRFDFRNFVVQCRREMILSKMEKEWPRPLCVEDPFDLSHNLSSGVN 1303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MTPAP	NP_001259129.1	NT_PAP_TUTase	193..333	CDD:143392	35/146 (24%)
MTPAP	NP_001259129.1	PAP_assoc	427..477	CDD:281779	14/52 (27%)
cid-1	NP_498099.1	PAP_assoc	574..625	CDD:367682
		NT_PAP_TUTase	1029..1151	CDD:143392	34/144 (24%)
		TRF4	1034..>1317	CDD:227585	72/298 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161118
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5260
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740