DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MTPAP and mtpap

DIOPT Version :9

Sequence 1:	NP_001259129.1	Gene:	MTPAP / 31081	FlyBaseID:	FBgn0024360	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	XP_002940378.2	Gene:	mtpap / 100492805	XenbaseID:	XB-GENE-958512	Length:	578	Species:	Xenopus tropicalis

Alignment Length:	539	Identity:	170/539 - (31%)
Similarity:	268/539 - (49%)	Gaps:	47/539 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNSLVRRSAQQLSLWRTYCIKHNASEAASPGRN-------AGRPNYEEFIGRHQRQAQCSIVVQV 58
            :.|:||.:.:.||    ..:......||:.|..       ..|..:.|.....|.||:.::::..
Frog    33 LRSVVRVTGRALS----NAVGGQQQVAAAAGGGLCLDEDPVTRRTFAEVQKERQEQAKHTVLINC 93

  Fly    59 SSEKSYEELYNYCSSFGSI--------MGAHHYCVRQDETLHYILLEYATSDEAAAAIGAGVTNG 115
            ....:..:...|.|..|.|        .|||       ..:.::..|...|..:|.::.. |.|.
Frog    94 PPNVNENKFLKYLSQHGQITRHFFYEGYGAH-------AVVEFLDRESIESLRSATSLPT-VENE 150

  Fly   116 ELSGVPVRSPFLWFRAAGGGRRSPKLVANTAPALLSLDGTRQ--VDQRHLLGLLRGAADIEEQVQ 178
            .:  :|.:|            |...|.:::|...:.:...||  :....|:..|..|.:||||..
Frog   151 CI--LPFKS------------RLFTLKSDSALGNVPVPCHRQTALPINELIQKLCKAQNIEEQAY 201

  Fly   179 QLYEHTRLNELGIRMRFLAALQVQQAIAGMFPAAQAQPFGSSVNGFGRMGCDLDLILRFDSDMGA 243
            .|.|..:|.:..||:|||.:..::......||.|...|:||:||.||::||||||.|..| |:..
Frog   202 ALLEEYQLTDENIRLRFLVSSLIKDIATAYFPEATVNPYGSTVNSFGKLGCDLDLFLDLD-DIQK 265

  Fly   244 KIPLEAAVPSRLVYHTKENLSNGRSQTQRHMECFGDMLHLFLPGVCHVRRILQARVPIIKYHHEH 308
            :|.::...|....|..| .:.:.|..|||.:...|:.:..|.||...|::||.||.|::::.|:.
Frog   266 RIAVKTTGPFATEYLIK-RVPSARVATQRILSVIGECIDNFGPGCTGVQKILNARCPLVRFSHQP 329

  Fly   309 LDLEVDLSMSNLTGFYMSELLYMFGEMDPRVRPLTFTIRRWAQTCGLTNPSPGRWISNFSLTCLV 373
            ..|:.||:..|......|||||::|..|.|:|.|.||:|.||:..|:|:..||.||:|||||.::
Frog   330 AGLQCDLTSDNRIALRSSELLYIYGCFDHRLRALVFTLRCWARVHGITSAIPGAWITNFSLTMMI 394

  Fly   374 MFFLQQLRQPILPTIGALAKAAEPGDSRVTEDGINCTFTRNVDRLGFRSRNQSSLSELLLQFFEF 438
            :||||:...|::||:..|...|...|..:. ||.:|:|..|::|:. .|:|..:|..||.:||||
Frog   395 LFFLQKRSPPVIPTLDHLKGLAGKEDKHII-DGHDCSFVSNLNRIK-PSQNSEALDVLLGEFFEF 457

  Fly   439 YSQFDFHNRAISLNEGKPLSKPDHSAMYIVNPLEQLLNVSKNVSLEECERLRIEVRNAAWVLESE 503
            |..|||....|.:.:||..:||:...:||.||.||.|||||||:..:.:|.....|.:||:::.:
Frog   458 YGNFDFSKNCIDIRKGKEQNKPEVCPLYIRNPFEQTLNVSKNVNQSQLDRFVALARESAWIMQEQ 522

  Fly   504 VENASVPEGDGQELSCGLL 522
            :..:...|.....|...||
Frog   523 ISQSVHKENTAWGLGTLLL 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MTPAP	NP_001259129.1	NT_PAP_TUTase	193..333	CDD:143392	50/139 (36%)
MTPAP	NP_001259129.1	PAP_assoc	427..477	CDD:281779	23/49 (47%)
mtpap	XP_002940378.2	RL	73..143	CDD:375339	14/76 (18%)
		NT_PAP_TUTase	216..354	CDD:143392	50/139 (36%)
		TRF4	<312..>513	CDD:227585	85/202 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	185	1.000	Domainoid score	I3330
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H10008
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3120
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1188122at2759
OrthoFinder	1	1.000	-	-		FOG0007101
OrthoInspector	1	1.000	-	-		oto102988
Panther	1	1.100	-	-	LDO	PTHR12271
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5151
SonicParanoid	1	1.000	-	-		X3421
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190